PhD Deniz Dalkara

Training

• 2002 – 2006
  Doctoral research, Université Louis Pasteur,Faculty of Pharmacy, Laboratory of Genetic Chemistry -With Dr Jean-Paul Behr and Guy Zuber: Intracytoplasmic delivery of proteins to live cells using synthetic vectors, Strasbourg, France
  
  

• 2006 – 2007
  Post-doc, Max Planck Institute of Biophysics,Dept. of Biophysical Chemistry – With Pr. Ernst Bamberg: Investigating the structure and structure and function of Chanelrhodopsin, a light activated ion channel, Frankfurt, Germany
  
  

• 2007 – 2012
  Post­doc, University of California Berkeley,Department of Chemical engineering and Helen Wills Institute of Neuroscience with Pr. David Schaffer and Pr. John Flannery: Engineering AAV vectors for retinal gene delivery , CA, USA
  
  

Education

•  
  Bachelor's degree in Biology Middle East Technical University, Ankara, Turkey
  
  

•  
  PhD, Cell and Molecular Biology Université Louis Pasteur, Strasbourg, France
  
  

• Macé E., Caplette R., Marre O., Sengupta A., Chaffiol A., Barbe P., Desrosiers M., Bamberg E., Sahel JA., Picaud S., Duebel J., Dalkara D. Targeting channelrhodopsin-2 to ON-bipolar cells with vitreally administered AAV restores ON and OFF visual responses in blind mice. Mol Ther, 2015.

• Vacca O., Darche M., Schaffer DV, Flannery JC, Sahel JA, Rendon A, Dalkara D. AAV-mediated gene delivery in Dp71-null mouse model with compromised barriers. Glia. 2013, Dec 31.

• Dalkara D, Duebel J, Sahel JA. Gene therapy for the eye focus on mutation-independent approaches. Curr Opin Neurol. 2015 Feb;28(1):51-60.

• Dalkara D, Byrne LC, Klimczak RR, Visel M, Yin L, Merigan WH, Flannery JG, Schaffer DV. In Vivo-Directed Evolution of a New Adeno-Associated Virus for Therapeutic Outer-Retinal Gene Delivery from the Vitreous. Sci Trans Med. 2013 Jun; Vol 5 Issue 189.

• Dalkara D, Kolstad KD, Caporale N, Visel M, Klimczak RR, Schaffer DV, Flannery JG. Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous. Mol Ther. 2009 Dec;17(12):2096-102.

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