Prof. Dr. Miriam Agler-Rosenbaum
Biological and related sciences, Microbial bioelectrochemistry, Microbial electrophysiology
INSERM
Biological and related sciences, Health
Gene delivery technologies and retinal gene therapy
Gene delivery (Adeno-associated virus, nanoparticles)
Gene therapy
Optogenetics
Retinal degeneration
MIT innovators under 35 award – France (2014)
Euretina Science and Medicine Innovation Award (2013)
Max Planck Fellowship (2006)
Biovalley PhD thesis award Société de Biologie de Strasbourg (2006)
Fellowship from the Ministry of Research and Technology (2002 – 2005)
English, French, Turkish
Macé E., Caplette R., Marre O., Sengupta A., Chaffiol A., Barbe P., Desrosiers M., Bamberg E., Sahel JA., Picaud S., Duebel J., Dalkara D. Targeting channelrhodopsin-2 to ON-bipolar cells with vitreally administered AAV restores ON and OFF visual responses in blind mice. Mol Ther, 2015.
Vacca O., Darche M., Schaffer DV, Flannery JC, Sahel JA, Rendon A, Dalkara D. AAV-mediated gene delivery in Dp71-null mouse model with compromised barriers. Glia. 2013, Dec 31.
Dalkara D, Duebel J, Sahel JA. Gene therapy for the eye focus on mutation-independent approaches. Curr Opin Neurol. 2015 Feb;28(1):51-60.
Dalkara D, Byrne LC, Klimczak RR, Visel M, Yin L, Merigan WH, Flannery JG, Schaffer DV. In Vivo-Directed Evolution of a New Adeno-Associated Virus for Therapeutic Outer-Retinal Gene Delivery from the Vitreous. Sci Trans Med. 2013 Jun; Vol 5 Issue 189.
Dalkara D, Kolstad KD, Caporale N, Visel M, Klimczak RR, Schaffer DV, Flannery JG. Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous. Mol Ther. 2009 Dec;17(12):2096-102.
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Biological and related sciences, Microbial bioelectrochemistry, Microbial electrophysiology
Biological and related sciences, Physical sciences, Environmental virology, Molecular and structural biology, biochemistry
Health, Public Health
Biological and related sciences, Evolution, genomics, bioinformatics