Short CV/Education and training

Education

  • 1989 – 1996
    The European School, Culham, Oxfordshire, UK, European Baccalaureate: 13 subjects, 7.9 (out of 10) overall

  • 1996 – 2000
    University of Sussex, UK, School of Biological Sciences, BSc (Hons) 1st Class, Molecular Genetics in Biotechnology (with Industrial Placement)

  • 2000 – 2003
    University of Manchester, UK, School of Biological Sciences, PhD Molecular Pharmacology: “The impact of tumour hypoxia on drug-induced apoptosis”

Work experience

  • 1995
    Bayer AG, Leverkusen, Germany, Summer student, biotechnology research

  • 1998 – 1999
    AstraZeneca Pharmaceuticals, Cheshire, UK, Industrial Placement student, researching obesity

  • 2004 – 2008
    Stanford University, USA, Department of Radiation Oncology, Postdoctoral Fellow, hypoxia and metastasis

  • 2008 – 2012
    The Institute of Cancer Research, London, UK, Division of Cancer Biology, Team Leader, hypoxia and metastasis

  • Since 2012
    Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Denmark, Group Leader, tumour microenvironment

Selected publications

Senior author:

  • Djidja, M-C., Chang, J., Hadjiprocopis, A., Schmich, F., Sinclair, J., Mrsnik, M., Schoof, E.M., Barker, H.E., Linding, R., Jørgensen, C. and Erler, J.T. Identification of hypoxia-regulated proteins using MALDI mass spectrometry tissue imaging and quantitative analysis, Journal of Proteome Research 13 (2014), pp. 2297-313.

  • Chang, J., Nicolau, M., Cox, T.R., Wetterskog, D., Martens, J.W., Barker, H.E. and Erler, J.T. LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling, Breast Cancer Research 5 (2013), pp. R67.

  • Barker, H.E., Bird D., Lang, G. and Erler, J.T. Tumor-secreted LOXL2 activates fibroblasts through FAK signaling, Molecular Cancer Research 11 (2013), pp. 1425-36.

  • Cox, T.R., Bird, D., Baker, A-M., Barker, H.E., Ho, M.W-Y., Lang, G. and Erler, J.T. LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis, Cancer Research 73 (2013), pp.1723-32.

  • Baker, A-M., Bird, D., Welti, J., Gourlaouen, M., Lang, G., Murray, G.I., Reynolds, A.R., Cox, T.R. and Erler, J.T., Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis, Cancer Research 73 (2013), pp. 583-94.

  • Baker, A-M., Bird, D., Lang, G., Cox, T.R. and Erler, J.T. Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK, Oncogene 32 (2013), pp.1863-8.

  • Baker, A-M., Cox, T.R., Bird, D., Lang, G., Murray, G.I., Sun, X-F., Southall, S., Wilson, J. and Erler, J.T. The Role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer, Journal of the National Cancer Institute 103 (2011), pp. 407-24.

  • Barker, H.E, Chang, J., Cox, T.R., Lang, G., Bird, D., Nicolau, M., Evans, H.R., Gartland, A. and Erler, J.T., LOXL2-mediated matrix remodeling in metastasis and mammary gland involution, Cancer Research 71(2011), pp. 1561-72.

First author:

  • Erler, J.T., Bennewith, K.L., Cox, T.R., Lang, G., Bird, D., Le, Q-T., Koong, A. and Giaccia, A.J. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the pre-metastatic niche, Cancer Cell 15 (2009), pp. 35-44.

  • Erler, J.T., Bennewith, K.L., Nicolau, M., Dornhofer, N., Kong, C., Le, Q-T., Chi, J-T., Chi, Jeffrey, S.S. and Giaccia, A.J. Lysyl oxidase is essential for hypoxia-induced metastasis, Nature 440 (2006), pp.1222-1226.

  • Erler, J.T., Cawthorne, C.J., Williams, K.J., Koritzinsky, M., Wouters, B.G., Wilson, C., Miller, C., Demonacos, C, Stratford, I.J. and Dive, C. Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via HIF-1 dependent and independent mechanisms and contributes to drug resistance, Molecular and Cellular Biology 24 (2004), pp. 2875-2889.



Complete list of publications

Membership in scientific bodies/juries

  • British Society for Matrix Biology, since 2015

  • Danish Brain Tumour Biology Group, since 2014

  • Danish Society for Connective Tissue Biology, since 2014

  • EU-LIFE Translational Research Working Group (BRIC representative), since 2013

  • Danish Cancer Association, since 2012

  • Metastasis Research Society (Chair of Outreach Working Group), since 2012

  • European Association for Cancer Research, since 2008

  • Radiation Research Society, since 2006

  • American Association for Cancer Research, since 2002

  • British Association of Cancer Research, 2000-2014

  • British Pharmacological Society, 2000-2004

Additional qualifications

  • BSc (Hons) 1st class, Molecular Genetics, University of Sussex, 2000


Soft Skills/Other activities and achievements

Additional interests

  • Public outreach opportunities


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