Short CV/Education and training

  • 1990
    M. Phil. in Neuroscience, Université Claude Bernard, Lyon, France

  • 1993
    Ph.D. in Neuroscience, Université Claude Bernard, Lyon, France

  • 1993 – 2002
    Postdoctoral fellow and Research Associate at the Karolinska Institute, Stockholm, Sweden; University of Birmingham, United Kingdom; The Rockefeller University, New York, USA

  • Since 2003
    Head of the Section of Molecular Neurophysiology, Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden

Selected publications

  • Chergui K., Charlety P.J., Akaoka H., Saunier C.F., Brunet J.L., Buda M., Svensson T.H. and Chouvet G. Tonic activation of NMDA receptors causes spontaneous burst discharge of rat midbrain dopamine neurons in vivo. European Journal of Neuroscience 5(2):137-144, 1993.

  • Chergui K., Bouron A., Normand E. and Mulle C. Functional GluR6 kainate receptors in the striatum: indirect downregulation of synaptic transmission. The Journal of Neuroscience 20(6):2175-2182, 2000.

  • Chergui K., Svenningsson P. and Greengard P. Cyclin-dependent kinase-5 regulates glutamatergic and dopaminergic transmission in the striatum. Proc. Natl. Acad. Sci. U S A. 101(7):2191-2196, 2004.

  • Chergui K., Svenningsson P. and Greengard P. Physiological role for casein kinase 1 in glutamatergic synaptic transmission. The Journal of Neuroscience 25(28):6601-6609, 2005.

  • Svenningsson P., Chergui K., Rachleff I., Flajolet M., Zhang X., El Yacoubi M., Vaugeois J.-M., Nomikos G.G. and Greengard P. Alterations in 5-HT1B receptor function by p11 in depression-like states. Science 311(5757): 77-80, 2006.

  • Schotanus S.M. and Chergui K. Dopamine D1 receptors and group I metabotropic glutamate receptors contribute to the induction of long-term potentiation in the nucleus accumbens. Neuropharmacology 54(5): 837-844, 2008.

  • Chergui K. Dopamine induces a GluN2A-dependent form of long term depression of NMDA synaptic responses in the nucleus accumbens. Neuropharmacology, 60(6):975-81, 2011.

  • Zhang X., Feng Z.-J. and Chergui K. GluN2D-containing NMDA receptors inhibit neurotransmission in the mouse striatum through a cholinergic mechanism: implication for Parkinson's disease. Journal of Neurochemistry, 129(4): 581-90, 2014.

  • Feng Z.-J., Zhang X. and Chergui K. Allosteric modulation of NMDA receptors alters neurotransmission in the striatum of a mouse model of Parkinson's disease. Experimental Neurology, 255: 154-60, 2014.

  • Zhang X., Feng Z.-J. and Chergui K. Allosteric modulation of GluN2C/GluN2D-containing NMDA receptors bidirectionally modulates dopamine release: implication for Parkinson's disease. British Journal of Pharmacology, 171(16):3938-45, 2014.

Additional qualifications

  • "Docent" in neuroscience, 2006

  • Senior lecturer in neurobiology, 2010

Soft Skills/Other activities and achievements

Other activities and achievements/family

  • Teaching activity: co-organizer of the Neuroscience course for medical students at the Karolinska Institute.


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