Prof. Dr. Amparo Acker-Palmer
Biological and related sciences , Health, Cell Biology, Cellular and Molecular Neuroscience, Vascular Biology, Tumour Biology
Biological and related sciences , Physical sciences, Health
Molecular, Cellular & Biochemical Sciences
DNA damage & repair and the link to human pathologies
ERC Starting Grant 2014, European Research Council, 2015 – 2020
BSIO Female Independency Award 2014, Berlin School of Integrative Oncology (BSIO), German Research Foundation, Germany, 2014 – 2017
Helmholtz Association Young Investigators Group Helmholtz Association of German Research Centres, Germany, 2014 – 2019
VR-NT Project Grant for Junior Researchers Swedish Research Council, Sweden. Sponsor institution: Karolinska Institute. (declined in favour of MDC/Helmholtz Association Young Investigators Group), 2014 – 2017
International Post-Doctoral Research Fellowship American-Italian Cancer Foundation, NY, USA (2-year fellowship program with 2nd year fellowship awarded after competitive renewal), 2008 – 2010
Research Scientist Fellowship, Telethon Foundation, Italy, 2001 – 2002
English, Italian
Callen E., Di Virgilio M., Kruhlak M.J., Nieto-Soler M., Wong N., Chen H.T., Faryabi R.B., Polato F., Santos M., Starnes L.M., Wesemann D.R., Lee J.E., Tubbs A., Sleckman B.P., Daniel J.A., Ge K., Alt F.W., Fernandez-Capetillo O., Nussenzweig M.C., and Nussenzweig A. 53BP1 mediates productive and mutagenic DNA repair through distinct phospho-protein interactions. Cell 2013 Jun 6;153(6):1266-80. Epub 2013 May 30.
Di Virgilio M., Callen E., Yamane A., Zhang W., Jankovic M., Gitlin A.D., Feldhahn N., Resch W., Oliveira T.Y., Chait B.T., Nussenzweig A., Casellas R., Robbiani D.F., and Nussenzweig M.C. Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching. Science 2013 Feb 8;339(6120):711-5. Epub 2013 Jan 10.
Klein I.A., Resch W., Jankovic M., Oliveira T., Yamane A., Nakahashi H., Di Virgilio M., Bothmer A., Nussenzweig A., Robbiani D.F., Casellas R., and Nussenzweig M.C. Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes. Cell 2011 Sep 30;147(1):95-106.
Bothmer A., Robbiani D.F., Di Virgilio M., Bunting S.F., Klein I.A., Feldhahn N., Barlow J., Chen H.T., Bosque D., Callen E., Nussenzweig A., and Nussenzweig M.C. Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1. Mol Cell 2011 May 6;42(3):319-29.
Pavri R., Gazumyan A., Jankovic M., Di Virgilio M., Klein I., Ansarah-Sobrinho C., Resch W., Yamane A., Reina San-Martin B., Barreto V., Nieland T.J., Root D.E., Casellas R., and Nussenzweig M.C. Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5. Cell 2010 Oct 1;143(1):122-33.
Callen E., Jankovic M., Wong N., Zha S., Chen H.T., Difilippantonio S., Di Virgilio M., Heidkamp G., Alt F.W., Nussenzweig A., and Nussenzweig M. Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Mol Cell 2009 May 15;34(3):285-97.
Dorsett Y., McBride K.M., Jankovic M., Gazumyan A., Thai T.H., Robbiani D.F., Di Virgilio M., Reina San-Martin B., Heidkamp G., Schwickert T.A., Eisenreich T., Rajewsky K., and Nussenzweig M.C. MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity 2008 May;28(5):630-8.
Di Virgilio M., Ying C.Y., and Gautier J. PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin. DNA Repair 2009 Nov 2;8(11):1311-20.
Di Virgilio M. and Gautier J. Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11. J Cell Biol 2005 Dec 5;171(5):765-71.
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Biological and related sciences , Health, Cell Biology, Cellular and Molecular Neuroscience, Vascular Biology, Tumour Biology
Biological and related sciences , Microbial bioelectrochemistry, Microbial electrophysiology
Biological and related sciences , Evolutionary biology, Animal behaviour, Gender studies, Science studies
Biological and related sciences , Evolutionary biology, Evolutionary genetics
Cancer can occur when things go wrong in our genes, but also occur when the processes to fix damaged genes goes wrong. AcademiaNet members Dr. Elisabetta Citterio, Dr. Michela Di Virgilio (photo), Dr. Jacqueline Jacobs and Prof. Rocio Sotillo study the mechanisms of DNA repair.