PhD Michela Di Virgilio

• Since 2014
  Member of the Adjunct Faculty, Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA
  
  

• Since 2014
  Junior Group Leader, Laboratory of DNA repair and Maintenance of Genome Stability, Max-Delbruck Center for Molecular Medicine (MDC), Berlin, Germany
  
  

• Since 2014
  Member of the Extended Faculty, Berlin School of Integrative Oncology (BSIO), German Research Foundation, Berlin, Germany
  
  

• 2012 – 2014
  Research Associate, Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA
  
  

• 2007 – 2012
  Postdoctoral Associate, Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA
  
  

• 2002 – 2007
  Research Staff Associate, Department of Genetics & Development, and Institute for Cancer Genetics, Columbia University, New York, NY, USA
  
  

• 2003 – 2006
  Graduate Student, Università degli Studi di Milano, Milan, Italy; Department of Genetics & Development, and Institute for Cancer Genetics, Columbia University, New York, NY, USA
  
  

• 2001 – 2002
  Research Fellow, Department of Experimental Oncology, Istituto Nazionale dei Tumori, Milan, Italy
  
  

• 2001
  B.S. (Biotechnology), Cum Laude, Università degli Studi Bologna
  
  

• 1999 – 2001
  Undergraduate Student, Department of Experimental Oncology, Istituto Nazionale dei Tumori, Milan, Italy
  
  

• Callen E., Di Virgilio M., Kruhlak M.J., Nieto-Soler M., Wong N., Chen H.T., Faryabi R.B., Polato F., Santos M., Starnes L.M., Wesemann D.R., Lee J.E., Tubbs A., Sleckman B.P., Daniel J.A., Ge K., Alt F.W., Fernandez-Capetillo O., Nussenzweig M.C., and Nussenzweig A. 53BP1 mediates productive and mutagenic DNA repair through distinct phospho-protein interactions. Cell 2013 Jun 6;153(6):1266-80. Epub 2013 May 30.

• Di Virgilio M., Callen E., Yamane A., Zhang W., Jankovic M., Gitlin A.D., Feldhahn N., Resch W., Oliveira T.Y., Chait B.T., Nussenzweig A., Casellas R., Robbiani D.F., and Nussenzweig M.C. Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching. Science 2013 Feb 8;339(6120):711-5. Epub 2013 Jan 10.

• Klein I.A., Resch W., Jankovic M., Oliveira T., Yamane A., Nakahashi H., Di Virgilio M., Bothmer A., Nussenzweig A., Robbiani D.F., Casellas R., and Nussenzweig M.C. Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes. Cell 2011 Sep 30;147(1):95-106.

• Bothmer A., Robbiani D.F., Di Virgilio M., Bunting S.F., Klein I.A., Feldhahn N., Barlow J., Chen H.T., Bosque D., Callen E., Nussenzweig A., and Nussenzweig M.C. Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1. Mol Cell 2011 May 6;42(3):319-29.

• Pavri R., Gazumyan A., Jankovic M., Di Virgilio M., Klein I., Ansarah-Sobrinho C., Resch W., Yamane A., Reina San-Martin B., Barreto V., Nieland T.J., Root D.E., Casellas R., and Nussenzweig M.C. Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5. Cell 2010 Oct 1;143(1):122-33.

• Callen E., Jankovic M., Wong N., Zha S., Chen H.T., Difilippantonio S., Di Virgilio M., Heidkamp G., Alt F.W., Nussenzweig A., and Nussenzweig M. Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Mol Cell 2009 May 15;34(3):285-97.

• Dorsett Y., McBride K.M., Jankovic M., Gazumyan A., Thai T.H., Robbiani D.F., Di Virgilio M., Reina San-Martin B., Heidkamp G., Schwickert T.A., Eisenreich T., Rajewsky K., and Nussenzweig M.C. MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity 2008 May;28(5):630-8.

• Di Virgilio M., Ying C.Y., and Gautier J. PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin. DNA Repair 2009 Nov 2;8(11):1311-20.

• Di Virgilio M. and Gautier J. Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11. J Cell Biol 2005 Dec 5;171(5):765-71.

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