Prof. Dr. Heike Allgayer
Biological and related sciences, Health
Health
Epigenetics
English
PhD from the University of Edinburgh. Lecturer and Senior Lecturer at Imperial College until 2001.
Ten years in senior scientific roles in the UK biotech sector followed by three years at Pfizer.
Currently International Director for PraxisUnico, the UK network that supports professionals working in knowledge exchange and commercialisation. Served on a number of committees for UK research councils and is a Visiting Professor at Imperial College. Passionate about public engagement and the author of two popular science books, "The Epigenetics Revolution" and "Junk DNA".
Carey N, Marques CJ, Reik W. DNA demethylases: a new epigenetic frontier in drug discovery. Drug Discov Today. 2011 Aug;16(15-16): 683-90.
Best JD, Carey N. Epigenetic therapies for non-oncology indications. Drug Discov Today. 2010 Dec;15(23-24): 1008-14.
Best JD, Carey N. Epigenetic opportunities and challenges in cancer. Drug Discov Today. 2010 Jan;15(1-2): 65-70.
Flanagan JM, Funes JM, Henderson S, Wild L, Carey N, Boshoff C. Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets. Mol Cancer Ther. 2009 Jan;8(1): 249-60.
Carey N, La Thangue NB. Histone deacetylase inhibitors: gathering pace. Curr Opin Pharmacol. 2006 Aug;6(4): 369-75. Epub 2006 Jun 14.
Sadusky TJ, Kemp TJ, Simon M, Carey N, Coulton GR. Identification of Serhl, a new member of the serine hydrolase family induced by passive stretch of skeletal muscle in vivo. Genomics. 2001 Apr 1;73(1): 38-49.
Eriksson M, Ansved T, Edstrom L, Wells DJ, Watt DJ, Anvret M, Carey N. Independent regulation of the myotonic dystrophy 1 locus genes postnatally and during adult skeletal muscle regeneration. J Biol Chem. 2000 Jun 30;275(26): 19964-9.
Eriksson M, Ansved T, Edström L, Anvret M, Carey N. Simultaneous analysis of expression of the three myotonic dystrophy locus genes in adult skeletal muscle samples: the CTG expansion correlates inversely with DMPK and 59 expression levels, but not DMAHP levels. Hum Mol Genet. 1999 Jun;8(6): 1053-60. PubMed PMID: 10332037.
Drug discovery in epigenetics
Analyses of pathological pathways in myotonic dystrophy
Member of BBSRC Biosciences for Industry panel, since 2011
Member of MRC Molecular and Cellular Medicine Board, since 2011
Interviewed 3 times on Radio 4 Today programme, talking about epigenetics: Epigenetics – The key to cancer?
Talked about epigenetics for the BBC World Service
Popular science article in BBC Focus magazine: Deadly Mega Erruption
Multiple public engagement events including: Edinburgh Science Festival; Edinburgh International Book Festival;Cheltenham Science Festival; British Science Festival; Royal Society Summer Science exhibition; U3A at the Royal Institution
Blogs for The Huffington Post: Entry on Huffpost.com
Public speaking
Supporting younger scientists
Accessible scientific writing
Other activities and interests: Women in science, Enthusing children and young adults about science, Translational science, Scientific career paths, Media
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Biological and related sciences, Health
Health, Obesity, Diabetes, Immunology
Biological and related sciences, Health, Cell Biology, Cellular signaling, Cancer biology, Cancer therapy
Health, Academic Medicine