PhD Sonja Aits

• Since 2017 Associate Researcher, Dept. of Experimental Medical Science, Lund University, Sweden

• Since 2016
  Visiting Scientist, Gene Regulation Laboratory (head: Prof. Ricky Johnstone), Peter MacCallum Cancer Centre, Melbourne, Australia
  
  

• 2016 – 2017
  Senior Scientist, Membrane Integrity Group (head: Dr. Jesper Nylandsted), Cell Death and Metabolism Unit, Danish Cancer Society Research Center, Copenhagen, Denmark
  
  

• 2010 – 2016
  Visiting scientist/Postdoc, Marja Jäättelä group, Cell Death and Metabolism Unit, Danish Cancer Society Research Center, Denmark
  
  

• 2010
  PhD in Biomedicine, Lund University, Sweden
  
  

• 2005 – 2010
  Reasearch student/PhD student, Catharina Svanborg group, Dept. of Laboratory Medicine, Lund University, Sweden
  
  

• 2005
  MSc in Biomedicine, Lund University, Sweden
  
  

• 2005
  Master student, Mattias Höglund group, Dept. of Clinical Genetics, University Hospital Lund, Sweden
  
  

• 2003
  Vordiplom, Molecular Medicine Program, Friedrich-Alexander University, Erlangen-Nuremberg, Germany
  
  

• Pagliero RJ, D’Astolfo DS, Lelieveld D, Pratiwi RD, Aits S, Jäättelä M, Martin NI, Klumperman J, Egan DA. Discovery of small molecules that induce lysosomal cell death in cancer cell lines using an image-based screening platform. Assay Drug Dev Technol 2016; 14(8):489-510

• Aits S, Kricker J, Liu B, Ellegaard AM, Hämälistö S, Tvingsholm S, Corcelle-Termeau E, Høgh S, Farkas T, Jonassen AH, Gromova I, Mortensen M, Jäättelä M. Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay. Autophagy 2015; 11(8):1408-24

• Aits S, Jäättelä M, Nylandsted J. Methods for the quantification of lysosomal membrane permeabilization: a hallmark of lysosomal cell death. Methods Cell Biol 2015; 126: 261-85

• Aits S, Jäättelä M. Lysosomal cell death at a glance. J Cell Sci 2013; 126(9): 1905-12

• Groth-Pedersen L*, Aits S* (* shared first authorship), Corcelle-Termeau E, Petersen NHT, Nylandsted J, Jäättelä M. Identification of cytoskeleton-associated proteins essential for lysosomal stability and survival of human cancer cells. PLOS ONE 2012; 7(10): e45381

• Storm P*, Aits S* (* shared first authorship), Puthia MK*, Urbano A, Northen T, Powers S, Bowen B, Chao Y, Reindl W, Lee DY, Sullivan NL, Zhang J, Trulsson M, Yang H, Watson JD, Svanborg C. Conserved features of cancer cells define their sensitivity to HAMLET-induced death; c-Myc and glycolysis. Oncogene 2011; 30(48): 4765-79

• Aits S, Gustafsson L, Hallgren O, Brest P, Gustafsson M, Trulsson M, Mossberg AK, Simon HU, Mograbi B, Svanborg C. HAMLET (human alpha-lactalbumin made lethal to tumor cells) triggers autophagic tumor cell death. Int J Cancer 2009; 124(5): 1008-19 (fast track)

• Lysosome disruption as anti-cancer therapy

• High-content screening for regulators of cell death, lysosomal and mitochondrial damage

• Lysosome disruption in neurological diseases

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