Dr. Tsipe Aavik
Biological and related sciences , Environment, Plant Ecology, Conservation Biology, Landscape Genomics
Peter MacCallum Cancer Centre, Melbourne
Biological and related sciences
cell biology, molecular biology, biomedicine
cell death, lysosomes, apoptosis, autophagy, cancer biology, neurobiology, high-content screening
Starting Grant, Swedish Research Council, 2016
Swedish Research Council International Postdoc Fellow, 2012 – 2014
Swedish Society for Medical Research (SSMF) Postdoctoral Fellowship [returned due to incompatibility with other fellowship], 2012
Danish, English, French, German, Swedish
Since 2017 Associate Researcher, Dept. of Experimental Medical Science, Lund University, Sweden
Pagliero RJ, D’Astolfo DS, Lelieveld D, Pratiwi RD, Aits S, Jäättelä M, Martin NI, Klumperman J, Egan DA. Discovery of small molecules that induce lysosomal cell death in cancer cell lines using an image-based screening platform. Assay Drug Dev Technol 2016; 14(8):489-510
Aits S, Kricker J, Liu B, Ellegaard AM, Hämälistö S, Tvingsholm S, Corcelle-Termeau E, Høgh S, Farkas T, Jonassen AH, Gromova I, Mortensen M, Jäättelä M. Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay. Autophagy 2015; 11(8):1408-24
Aits S, Jäättelä M, Nylandsted J. Methods for the quantification of lysosomal membrane permeabilization: a hallmark of lysosomal cell death. Methods Cell Biol 2015; 126: 261-85
Aits S, Jäättelä M. Lysosomal cell death at a glance. J Cell Sci 2013; 126(9): 1905-12
Groth-Pedersen L*, Aits S* (* shared first authorship), Corcelle-Termeau E, Petersen NHT, Nylandsted J, Jäättelä M. Identification of cytoskeleton-associated proteins essential for lysosomal stability and survival of human cancer cells. PLOS ONE 2012; 7(10): e45381
Storm P*, Aits S* (* shared first authorship), Puthia MK*, Urbano A, Northen T, Powers S, Bowen B, Chao Y, Reindl W, Lee DY, Sullivan NL, Zhang J, Trulsson M, Yang H, Watson JD, Svanborg C. Conserved features of cancer cells define their sensitivity to HAMLET-induced death; c-Myc and glycolysis. Oncogene 2011; 30(48): 4765-79
Aits S, Gustafsson L, Hallgren O, Brest P, Gustafsson M, Trulsson M, Mossberg AK, Simon HU, Mograbi B, Svanborg C. HAMLET (human alpha-lactalbumin made lethal to tumor cells) triggers autophagic tumor cell death. Int J Cancer 2009; 124(5): 1008-19 (fast track)
Lysosome disruption as anti-cancer therapy
High-content screening for regulators of cell death, lysosomal and mitochondrial damage
Lysosome disruption in neurological diseases
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Biological and related sciences , Environment, Plant Ecology, Conservation Biology, Landscape Genomics
Biological and related sciences , Health
Biological and related sciences , Evolution, genomics, bioinformatics
Biological and related sciences , Health, Cell Biology, Cellular signaling, Cancer biology, Cancer therapy