Prof. Agnieszka Chacinska

Education and degrees:

• 1988 – 1993
  Study of Biology, University of Warsaw, Poland
  
  

• 1993
  Master Degree in Molecular Biology, University of Warsaw
  
  

• 1994 – 2000
  PhD in Biochemistry, Institute of Biochemistry and Biophysics, Warsaw, Poland
  
  

• 2008
  Dr hab., Institute of Biochemistry and Biophysics, Warsaw, Poland
  
  

• 2014
  Professor of Biological Sciences, nomination by the President of the Republic of Poland
  
  

Research experience and appointments:

• 1994 – 2000
  Doctoral research with Prof. Magdalena Boguta, Institute of Biochemistry and Biophysics, Warsaw, Poland
  
  

• 1996 – 1998
  Visiting scientist in the laboratory of Prof. Gottfried Schatz, Biozentrum, University of Basel, Switzerland
  
  

• 1999
  Visiting scientist in the laboratory of Dr. Sabine Rospert, Max Planck Research Unit, Halle, Germany
  
  

• 2001 – 2004
  Postdoctoral Fellow in the laboratory of Prof. Nikolaus Pfanner, University of Freiburg, Germany
  
  

• 2004 – 2009
  Group Leader, Institute for Biochemistry and Molecular Biology, University of Freiburg, Germany
  
  

• 2007 – 2010
  Project Leader in the Collaborative Research Centre 746 (SFB 746), Germany
  
  

• 2007 – 2010
  Member of the Board, Collaborative Research Centre 746 (SFB 746), Germany
  
  

• 2008 – 2009
  Associate Member of Excellence Cluster BIOSS–Centre for Biological Signalling Studies, University of Freiburg, Germany
  
  

• Since 2009
  Professor and Leader of the Laboratory of Mitochondrial Biogenesis at the International Institute of Molecular and Cell Biology in Warsaw, Poland
  
  

• Chacinska, A., Lind, M., Frazier, A.E., Dudek, J., Meisinger, C., Geissler, A., Sickmann, A., Meyer, H.E., Truscott, K.N., Guiard, B., Pfanner, N., Rehling, P. (2005). Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17. Cell 120, 817-29.

• Chacinska, A., Pfannschmidt, S., Wiedemann, N., Kozjak, V., Sanjuán Szklarz, L.K., Schulze-Specking, A., Truscott, K.N., Guiard, B., Meisinger, C., Pfanner, N. (2004). Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins. EMBO J. 23, 3735-46.

• Sickmann, A., Reinders, J., Wagner, Y., Joppich, C., Zahedi, R., Meyer, H.E., Schönfisch, B., Perschil, I., Chacinska, A., Guiard, B., Rehling, P., Pfanner, N., Meisinger, C. (2003). The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A. 100, 13207-12.

• Chacinska, A., Koehler, C.M., Milenkovic, D., Lithgow, T., Pfanner, N. (2009). Importing mitochondrial proteins: machineries and mechanisms. Cell 138, 628-644.

• von der Malsburg, K., Müller, J.M., Bohnert, M., Oeljeklaus, S., Kwiatkowska, P., Becker, T., Loniewska-Lwowska, A., Wiese, S., Rao, S., Milenkovic, D., Hutu, D.P., Zerbes, R.M., Schulze-Specking, A., Meyer, H.E., Martinou, J.C., Rospert, S., Rehling, P., Meisinger, C., Veenhuis, M., Warscheid, B., van der Klei, I.J., Pfanner ,N.*, Chacinska, A.*, van der Laan, M. (2011). Dual Role of Mitofilin in Mitochondrial Membrane Organization and Protein Biogenesis. Developmental Cell, 21, 694-707.

  (*co-corresponding author)

• Bragoszewski, P., Gornicka, A., Sztolsztener, M.E., and Chacinska, A. (2013). The ubiquitin-proteasome system regulates mitochondrial intermembrane space proteins. Mol Cell Biol 33, 2136-48.

• Wrobel, L., Trojanowska, A., Sztolsztener, M.E., and Chacinska, A. (2013). Mitochondrial protein import: Mia40 facilitates Tim22 translocation into the inner membrane of mitochondria. Mol Biol Cell 24, 543-554.

• Sztolsztener, M.E., Brewinska, A., Guiard, B., and Chacinska, A. (2013). Disulfide bond formation: sulfhydryl oxidase ALR controls mitochondrial biogenesis of human MIA40. Traffic 14, 309-320.

• Gornicka, A., Bragoszewski, P., Chroscicki, P., Wenz, L.S., Schulz, C., Rehling, P., Chacinska, A. (2014). A discrete pathway for the transfer of intermembrane space proteins across the outer membrane of mitochondria . Mol. Biol. Cell 25, 3999-4009.

• Sokol, A.M., Sztolsztener, M.E., Wasolewski, M., Heinz, E., Chacinska, A. (2014). Mitochondrial protein translocases for survival and wellbeing. FEBS Lett. 588, 2484-2485.

• Referee for a number of international scientific journals including the EMBO Journal, EMBO Reports, Nature Structural and Molecular Biology, Cell Reports, PNAS, Journal of Cell Biology, Journal of Molecular Biology, Eukaryotic Cell, BBA, Molecular Biology of the Cell.

• Referee and/or panel expert for funding institutions: Human Frontier Science Program, Strasbourg; Australian Research Council; BBSRC, UK; DFG, Germany; Estonian Science Foundation, Estonia; Foundation for Polish Science; German-Israeli Foundation for Scientific Research and Development (GIF); National Science Centre, Poland.

• Panel expert of European Research Council, Foundation for Polish Sciences, National Science Centre Poland.

• Member of the Scientific Board of Institute of Biochemistry and Biophysics Polish Academy of Science.

• http://sciencecareers.sciencemag.org/career_magazine/previous_issues/articles/2010_03_19/caredit.a1000027

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