Short CV/Education and training

Current and previous positions, period of appointment

  • Since 2016
    Subject representative for Division of Molecular Imaging

  • Since 2015
    Professor, Division of Molecular Imaging, Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University

  • 2013 – 2015
    Reader, Preclinical PET Platform, Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University

  • 2011 – 2013
    Researcher, Preclinical PET Platform, Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University

  • 2009 – 2011
    Researcher, Unit of Biomedical Radiation Sciences, Institute of Radiology, Oncology and Radiation Sciences, Uppsala University

  • 2003 – 2009
    Senior Researcher, Affibody AB, Bromma

  • 1999 – 2003
    Ph.D. student at Biomedical Radiation Sciences, Uppsala University

  • 1997 – 1998
    Postdoctoral researcher, Department of Organic Chemistry, Uppsala University

  • 1984 – 1996
    Researcher, Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

University education

  • 1977 – 1984
    Civil engineer in Chemical Technology, Moscow Institute for Chemical Technology (university status); Speciality: Technology of rear elements

Selected publications

  • Orlova A, Magnusson M, Eriksson T, Nilsson M, Larsson B, Höiden-Guthenberg I, Widström C, Carlsson J, Tolmachev V, Ståhl S, Nilsson F.Y. Tumor imaging a using picomolar affinity HER2 binding Affibody molecule. Cancer Res, 2006;66:4339-4348.

  • Tolmachev V, Orlova A, Pehrson R, Galli J, Baastrup B, Andersson K, Sandström M, Rosik D, Carlsson J, Lundqvist H, Wennborg A, Nilsson FY. Radionuclide therapy of HER2-positive micro-xenografts using a 177Lu-labeled HER2-specific Affibody molecule. Cancer Res, 2007;67:2773-2782.

  • Orlova A, Tolmachev V, Pehrson R, Lindborg M, Tran T, Sandström M, Nilsson FY, Wennborg A, Abrahmsén L, Feldwisch J. Synthetic Affibody Molecules: A Novel Class of Affinity Ligands for Molecular Imaging of HER2-Expressing Malignant Tumors. Cancer Res, 2007;67:2178-2186.

  • Honarvar H, Westerlund K, Altai M, Sandström M, Orlova A, Tolmachev V, Eriksson Karlström A. Feasibility of Affibody Molecule-Based PNA-Mediated Radionuclide Pretargeting of Malignant Tumors Theranostics. 2016 Jan 1;6(1):93-103.

  • Sörensen J, Velikyan I, Sandberg D, Wennborg A, Feldwisch J, Tolmachev V, Orlova A, Sandström M, Lubberink M, Olofsson H, Carlsson J, Lindman H. Measuring HER2-Receptor Expression In Metastatic Breast Cancer Using [(68)Ga]ABY-025 Affibody PET/CT. Theranostics, 2016 6(2):262-71.

  • Garousi J, Lindbo S, Nilvebrant j, Åstrand M, Buijs J, Sandström M, Honarvar H, Orlova A, Tolmachev V, Hober S. ADAPT, a novel scaffold protein-based probe for radionuclide imaging of molecular targets expression in disseminated cancer. Cancer Res. 2015 Oct 15;75(20):4364-71. doi: 10.1158/0008-5472.CAN-14-3497.

  • Tolmachev V, Varasteh Z, Honarvar H, Hosseinimehr SJ, Eriksson O, Jonasson P, Frejd FY, Abrahmsen L, Orlova A. Imaging of Platelet-Derived Growth Factor Receptor β Expression in Glioblastoma Xenografts Using Affibody Molecule 111In-DOTA-Z09591. J Nucl Med, 2014 Feb;55(2):294-300.

  • Tolmachev V, Malmberg J, Hofström C, Abrahmsén L, Bergman T, Sjöberg A, Sandström M, Gräslund T, Orlova A. Imaging of Insulinlike Growth Factor Type 1 Receptor in Prostate Cancer Xenografts Using the Affibody Molecule 111In-DOTA-ZIGF1R:4551. J Nucl Med, 2012;53:90-7.

  • Bass T, Rosestedt M, Bogdan M, Frejd F, Löfblom J, Tolmachev V, Stahl S, Orlova A. In vivo evaluation of a novel format of a bivalent HER3-targeting and albumin-binding therapeutic affibody construct. Sci Rep. 2017 Feb 23;7:43118.

  • Varasteh Z, Velikyan I, Lindeberg G, Sörensen J, Larhed M, Sandström M, Selvaraju RK, Malmberg J, Tolmachev V, Orlova A. Synthesis and characterization of a high affinity NOTA-conjugated bombesin antagonist for GRPR-targeted tumor imaging. Bioconjug Chem, 2013 Jul 17;24(7):1144-53.

  • Rosestedt M, Andersson KG, Mitran B , Tolmachev V, Löfblom J, Orlova A, Ståhl S. Affibody-mediated PET imaging of HER3 expression in malignant tumours. Sci Rep. 2015 Oct 19;5:15226. doi: 10.1038/srep15226.

Complete list of publications

Membership in scientific bodies/juries

Member of the editorial board

  • Scientific Reports

Membership in scientific societies

  • The Swedish Academy of Pharmaceutical Sciences, International Research group in Immuno-Scintigraphy and Therapy

  • International Society for Radiopharmaceutical Sciences, European Association of Nuclear Medicine

Grant proposal review process for

  • Swiss National Science Foundation (SNSF), 2016

  • Willy Gepts Research Foundation of the University Hospital Brussels (UZ Brussel), 2016

  • Austrian Science Fund (FWF), 2015

  • German Research Foundation (DFG), 2013

  • Prostate Cancer UK Research Awards, 2012

  • Cancer Research UK, 2011

  • Czech Science Foundation (GACR), 2011

  • Rumanian National Authority for Scientific Research, 2012

Peer-reviewing for journals

  • Biomaterials, Clinical Cancer Research; Cancer Biotherapy & Radiopharmaceuticals; Nature Protocol; Theranostics, European Journal of Nuclear Medicine and Molecular Imaging; European Journal of Nuclear Medicine and Molecular Imaging Research; Cancer Immunology Immunotherapy; Labelled Compounds and Radiopharmaceuticals; Journal of Nuclear Medicine; Journal of Nanomedicine; PLOS One; Amino Acids; Molecular Cancer Therapeutics; Molecular Imaging and Biology; Molecules; Nuclear Medicine and Biology; Computational and Structural Biotechnology Journal, European Journal of Medicinal Chemistry, Molecular Pharmaceutics, Molecular Imaging


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