Short CV/Education and training

  • 2012 – 2021
    Professor at King's College London, London

  • 1997 – 2012
    Team Leader, MRC NIMR, Mill Hill, London

  • 1991 – 1997
    Group leader at EMBL Heidelberg, Germany, in the Structures Program

  • 1986 – 1987
    Postdoctoral fellow at the Department of Biochemistry, University of Oxford, UK

  • 1988 – 1991
    Staff scientist position at EMBL Heidelberg, Germany, in the Biocomputing Program

  • 1983 – 1986
    Dottorato di Ricerca (equivalent to a PhD) at the Laboratory of Spectroscopy, University of Naples, Italy

  • 1981
    Laurea (equivalent to a Master) in Chemistry, University of Naples,Italy (Overall mark: 110/110 cum laude)

Selected publications

  • Prischi, F., Konarev, P.V., Iannuzzi, C., Pastore, C., Adinolfi, S., Martin, S.R., Svergun, D.I., Pastore, A. (2010) Structural bases for the interaction of frataxin with the central components of iron-sulfur cluster assembly. Nature Communications 1, 95.

  • Adinolfi, S., Iannuzzi, C., Prischi, F., Pastore, C., Iametti, S., Martin, S., Bonomi, F., Pastore, A. (2009) Bacterial frataxin CyaY is the gate keeper of iron sulfur formation catalysed by IscS. Nat. Struct. Mol. Biol. 16, 390-396.

  • Ehrnhoefer, D.E., Bieschke, J., Boeddrich, A., Herbst, M., Masino, L., Lurz, R., Engemann, S, Pastore, A., Wanker, E.W. (2008) Redirecting aggregation pathways: small molecule-mediated conversion of amyloidogenic polypeptides into unstructured, off-pathway oligomers. Nat. Struct. Mol. Biol. 15, 558-566.

  • Foury, F., Pastore, A. and Trincal, M. (2007) Acidic residues of yeast frataxin play an essential role in Fe-S cluster assembly. EMBO Reports 8, 194-199.

  • Nicastro, G., Menon, R., Masino, L., McDonalds, N.O., Pastore, A. (2005) The solution structure of the Josephin domain of ataxin-3: Structural determinants for molecular recognition. PNAS 102, 10493-10498.

  • Atkinson, R.A., Joseph, C., Kelly, G., Muskett, F.W.,Frenkiel, T.A., Nietlispach, D., Pastore, A. (2001) Ca2+-independent binding of an EF-hand domain to a novel motif: an alpha-actinin/titin complex. Nature Struct. Biol. 8, 853-857.

  • Musco, G, Kharrat, A., Stier, S., Fraternali, F., Gibson, TJ, Nilges, M., Pastore, A. (1997) The solution structure of the first KH domain of FMR1, the protein responsible for fragile X syndrome. Nature Structure Biology 4, 712-716.

  • Musco, G., Stier, G., Joseph, C., Castiglione Morelli, M.A., Nilges, M., Gibson, T.J., Pastore, A. (1996) Three-dimensional structure and stability of the KH domain: Molecular insights into the Fragile X syndrome. Cell 85, 237-245.

  • Pfuhl M., Winder S. and Pastore A. (1994) Nebulin, a helical actin binding protein. EMBO J. 1782-1789.

  • Cooke R.M., Wilkinson A.J., Baron M., Pastore A., Tappin M.J., Campbell I.D., Gregory H., Sheard B. (1987) The solution structure of human epidermal growth factor. Nature 327, 339-341.

Selected projects

  • Iron-sulfur cluster biogenesis and mitochondrial diseases

  • Poluglutamine and neurodegeneration

  • Regulatory muscle proteins

Membership in scientific bodies/juries

  • International Member of a panel for the Habilitation of Italian Scientists organized by the Italian Ministry (2013)

  • Member of an International panel for the assessment of University of Zurich (January 2013)

  • Reviewer for the Italian Ministry of University and Research (MIUR) for the assessment of Italian University (2012 – 2013)

  • Consultant for the evaluation of National Grants in Italy (MURST, MIUR, PRIN), Belgium, France (Pasteur Institute, BLANC), UK (Wellcome, MRC, BBSRC), Swiss National Science Foundation, Portugal and Spain (ICREA)

  • Editorial board member of J. Biol. Chem., PlosOne, Medicinal Chemistry, Prion, ScienceJet, PeerJ, The Open Biochemistry Journal and The Open Spectroscopy Journal

  • Panel member of DFG assessments to decide on applications for high field (1.2 GHz) NMR spectrometers in Germany (August 2012 and February 2013)

  • Panel member of the Scientific Advisory Board of Biotechnology Institute in Helsinki, Finland (December 2011)

  • Co-chairperson in the annual grant evaluation for the Portuguese Science Ministry (July 2009, 2010)

  • Panel member of the Roadmap Working Group of Experts for Biological and Medical Sciences (EU grants) (January 2008)

  • Panel member in a quinquennial evaluation of the Forth (Eraklion) and Fleming Institutes (Athens) (September 2007), in the Institute for Molecular Medicine in Munich, Germany (January 2005) and at the University of Ivry, France (March 2006)

  • Chief Editor of the Open Systems Biology Journal (2006 – 2010)

  • Chairperson of the CCPN committee (2004 – 2007)

Additional qualifications

  • "Qualification" for teaching in French Universities, May 2005 – 2009

  • "Qualification" for teaching in French Universities, May 2000 – 2004


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