Prof. Anne Angelillo-Scherrer

• 1982 – 1989
  Medical student, University of Geneva, Switzerland
  
  

• 1993
  MD thesis, University of Lausanne, Switzerland
  
  

• 1999
  FMH internal medicine & FMH hematology, University Hospitals of Geneva, Switzerland
  
  

• 2005
  Assistant professor (Swiss National Foundation professorship) University of Lausanne & attending physician, Service & Central Laboratory of Hematology, Lausanne University Hospital
  
  

• Since 2011
  Associate professor, University of Lausanne & attending physician, Service & Central Laboratory of Hematology, Lausanne University Hospital
  
  

• Carmeliet P, Lampugnani MG, Moons L, Breviario F, Compernolle V, Bono F, Balconi, G, Spagnulo R, Oosthuyse B, Dewerchin M, Zanetti, A, Angelillo A, Mattot V, Nuyens D, Lutgens E, Clotman F, de Ruiter MC, Gittenberger-de Groot A, Poelmann R, Lupu F, Herbert JM, Collen D, Dejana E. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell. 1999; 98: 147-57

• Heymans S, Luttun A, Nuyens D, Theilmeier G, Creemers E, Moons L,Dyspersin GD, Cleutjens JPM, Shipley M, Angelillo A, Levi M, Nüsse O, Baker A, Keshet E, Lupu F, Herbet JM, Smits JFM, Shapiro SD, Baes M, Borgers M, Collen D, Daemen MJAP, Carmeliet P. Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure. Nat Med. 1999; 5: 1135-42

• Angelillo-Scherrer A, de Frutos P, Aparicio C, Melis E, Savi P, Lupu F, Arnout J, DewerchinM, Hoylaerts MF, Herbert JM, Collen D, Dahlbäck B, Carmeliet P. Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis. Nat Med. 2001; 7: 215-21

• Luttun A, Tjwa M, Moons L, Wu Y, Angelillo-Scherrer A., Liao F, Nagy JA, Hooper A, Priller J, De Klerck B, Compernolle V, Daci E, Molinas CR, Koninckx P, Bohlen P, Dewerchin M, Herbert JM, Fava R, Matthys P, Carmeliet G, Collen D, Dvorak HF, Hicklin DJ, Carmeliet P. PlGF and its receptor Flt-1 targets to treat angiogenesis and inflammatory diseases. Nat Med. 2002; 8: 831-840

• Angelillo-Scherrer A, Burnier L, Flores N, Savi P, DeMol M, Schaeffer P, Herbert JM, Lemke G, Goff SP, Matsushima GK, Earp HS, Hoylaerts MF, Plaisance S, Conway EM, Collen D, Wehrle-Haller B, Carmeliet P. Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J Clin Invest. 2005; 115: 237-46

• Angelillo-Scherrer A, Burnier L, Lambrechts D, Fish RJ, Tjwa M, Plaisance S, Lambrechts D, DeMol M, Martinez-Soria E, Flores N, Maxwell P, Lemke G, Goff SP, Matsushima GK, Earp HS, CollenD, Izui S, Conway EM, Carmeliet P. Role of Gas6 in erythropoiesis and anemia in mice

  J Clin Invest. 2008; 118: 583-96

• Saller F, Brisset AC, Tchaikovski SN, Azevedo M, Chrast R, Fernandez JA, Schapira M, Hackeng TM, Griffin JH, Angelillo-Scherrer A. Generation and phenotypic analysis of protein S-deficient mice. Blood. 2009; 114: 2307-14

• Cosemans JM, Van Kruchten R, Olieslagers S, Schurgers LJ, Verheyen FK, Munnix IC, Waltenberger J, Angelillo-Scherrer A, Hoylaerts MF, Carmeliet P, Heemskerk JW

  Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization. J Thromb Haemost. 2010; 8: 1797-808

• Burnier L, Saller F, Kadi L, Brisset AC, Sugamele R, Baudino L, Bono F, Herbert JM, Carmeliet P, Schapira M, Izui S, Angelillo-Scherrer A. Gas6 deficiency in recipient mice of allogeneic transplantation alleviates hepatic graft-versus-host disease. Blood. 2010; 115: 3390-3397

• Angelillo-Scherrer A, Fontana P, Burnier L, Roth I, Sugamele R, Brisset, A, Morel S, Nolli S, Sutter E, Chassot A, Capron C, Borgel D, Saller F, Chanson M, Kwak BR. Connexin37 limits thrombus propensity by downregulating platelet reactivity. Circulation. 2011. 124:930-939

As principal investigator:

• Role of growth arrest-specific gene 6 and protein S in hemostasis, thrombosis & inflammation

• Role of the gap junction Connexin37 in hemostasis & thrombosis

• Blocking protein S to treat hemophilia

As co-investigator:

• The swiss venous thromboembolism cohort 65+ (supported by the Swiss National Foundation for Scientific Research, principal investigator: Prof. D. Aujesky, University of Berne)

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