Dr. Irene Agyepong
Health, Public Health
Biological and related sciences, Health
Hematology, Internal Medicine; Special focus: hemostasis and thrombosis, laboratory diagnosis particularly in the field of hemostasis and thrombosis, myeloproliferative neoplasms and their bleeding/thrombotic complications
Experimental and translational research in the field of hemostasis and thrombosis
Clinical research in the field of hemostasis and thrombosis
Experimental, translational and clinical research in the field of myeloproliferative neoplasms
CSL Behring – Prof. Heimburger Award, 2011
Bayer Hemophilia Award, 2008
Ellermann Prize (Prize of Hematology, Swiss Society of Hematology), 2008
Leenaards Prize, Lausanne, 2007
English, French, German
Carmeliet P, Lampugnani MG, Moons L, Breviario F, Compernolle V, Bono F, Balconi, G, Spagnulo R, Oosthuyse B, Dewerchin M, Zanetti, A, Angelillo A, Mattot V, Nuyens D, Lutgens E, Clotman F, de Ruiter MC, Gittenberger-de Groot A, Poelmann R, Lupu F, Herbert JM, Collen D, Dejana E. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell. 1999; 98: 147-57.
Heymans S, Luttun A, Nuyens D, Theilmeier G, Creemers E, Moons L,Dyspersin GD, Cleutjens JPM, Shipley M, Angelillo A, Levi M, Nüsse O, Baker A, Keshet E, Lupu F, Herbet JM, Smits JFM, Shapiro SD, Baes M, Borgers M, Collen D, Daemen MJAP, Carmeliet P. Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure. Nat Med. 1999; 5: 1135-42.
Angelillo-Scherrer A, de Frutos P, Aparicio C, Melis E, Savi P, Lupu F, Arnout J, DewerchinM, Hoylaerts MF, Herbert JM, Collen D, Dahlbäck B, Carmeliet P. Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis. Nat Med. 2001; 7: 215-21.
Luttun A, Tjwa M, Moons L, Wu Y, Angelillo-Scherrer A., Liao F, Nagy JA, Hooper A, Priller J, De Klerck B, Compernolle V, Daci E, Molinas CR, Koninckx P, Bohlen P, Dewerchin M, Herbert JM, Fava R, Matthys P, Carmeliet G, Collen D, Dvorak HF, Hicklin DJ, Carmeliet P. PlGF and its receptor Flt-1 targets to treat angiogenesis and inflammatory diseases. Nat Med. 2002; 8: 831-840.
Angelillo-Scherrer A, Burnier L, Flores N, Savi P, DeMol M, Schaeffer P, Herbert JM, Lemke G, Goff SP, Matsushima GK, Earp HS, Hoylaerts MF, Plaisance S, Conway EM, Collen D, Wehrle-Haller B, Carmeliet P. Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J Clin Invest. 2005; 115: 237-46.
Angelillo-Scherrer A, Burnier L, Lambrechts D, Fish RJ, Tjwa M, Plaisance S, Lambrechts D, DeMol M, Martinez-Soria E, Flores N, Maxwell P, Lemke G, Goff SP, Matsushima GK, Earp HS, CollenD, Izui S, Conway EM, Carmeliet P. Role of Gas6 in erythropoiesis and anemia in mice, J Clin Invest. 2008; 118: 583-96.
Saller F, Brisset AC, Tchaikovski SN, Azevedo M, Chrast R, Fernandez JA, Schapira M, Hackeng TM, Griffin JH, Angelillo-Scherrer A. Generation and phenotypic analysis of protein S-deficient mice. Blood. 2009; 114: 2307-14.
Cosemans JM, Van Kruchten R, Olieslagers S, Schurgers LJ, Verheyen FK, Munnix IC, Waltenberger J, Angelillo-Scherrer A, Hoylaerts MF, Carmeliet P, Heemskerk JW. Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization. J Thromb Haemost. 2010; 8: 1797-808.
Burnier L, Saller F, Kadi L, Brisset AC, Sugamele R, Baudino L, Bono F, Herbert JM, Carmeliet P, Schapira M, Izui S, Angelillo-Scherrer A. Gas6 deficiency in recipient mice of allogeneic transplantation alleviates hepatic graft-versus-host disease. Blood. 2010; 115: 3390-3397.
Angelillo-Scherrer A, Fontana P, Burnier L, Roth I, Sugamele R, Brisset, A, Morel S, Nolli S, Sutter E, Chassot A, Capron C, Borgel D, Saller F, Chanson M, Kwak BR. Connexin37 limits thrombus propensity by downregulating platelet reactivity. Circulation. 2011. 124: 930-939.
Role of growth arrest-specific gene 6 and protein S in hemostasis, thrombosis & inflammation
Role of the gap junction Connexin37 in hemostasis & thrombosis
Blocking protein S to treat hemophilia
The swiss venous thromboembolism cohort 65+ (supported by the Swiss National Foundation for Scientific Research, principal investigator: Prof. D. Aujesky, University of Berne)
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Health, Public Health
Biological and related sciences, Microbial bioelectrochemistry, Microbial electrophysiology
Biological and related sciences, Environment, Plant Ecology, Conservation Biology, Landscape Genomics
Biological and related sciences, Health, Cell Biology, Cellular signaling, Cancer biology, Cancer therapy