Prof. Anne Angelillo-Scherrer

• Since 2021
  Deputy Director of the Department for BioMedical Research, University of Bern, Bern, Switzerland (since April 2021)
  
  

• Since 2020
  Member of the direction of the Bern Center for Precision Medicine, University of Bern, Bern, Switzerland (since October 2020)
  
  

• Since 2020
  Member of the committee “Carriers” (representative of Division III), Swiss National Science Foundation, panel president Ambizione/PROSPER/SCORE
  
  

• Since 2019
  Member of the National MD-PhD program Expert Committee
  
  

• Since 2018
  Member of the Swiss National Science Foundation Researcch Council, Division III (clinician, experimental and translational medicine), Bern, Switzerland and Member of the Senate of the Swiss Academy of Medical Sciences
  
  

• 2017
  Member of the SNF Research Commission, University of Bern, Bern, Switzerland
  
  

• Since 2013
  Full Professor of Hematology, Physician-in-Chief/Chairwoman of the Department of Hematology & Central Hematology Laboratory, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland
  
  

• 2011 – 2013
  Associate professor, University of Lausanne & attending physician, Service & Central Laboratory of Hematology, Lausanne University Hospital. Lausanne, Switzerland
  
  

• 2005
  Assistant professor (Swiss National Foundation professorship) University of Lausanne & attending physician, Service & Central Laboratory of Hematology, Lausanne University Hospital, Lausanne, Switzerland
  
  

• 1999
  FMH internal medicine & FMH hematology, University Hospitals of Geneva, Switzerland
  
  

• 1993
  MD thesis, University of Lausanne, Switzerland
  
  

• 1982 – 1989
  Medical student, University of Geneva, Switzerland
  
  

• Carmeliet P, Lampugnani MG, Moons L, Breviario F, Compernolle V, Bono F, Balconi, G, Spagnulo R, Oosthuyse B, Dewerchin M, Zanetti, A, Angelillo A, Mattot V, Nuyens D, Lutgens E, Clotman F, de Ruiter MC, Gittenberger-de Groot A, Poelmann R, Lupu F, Herbert JM, Collen D, Dejana E. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell. 1999; 98: 147-57.

• Heymans S, Luttun A, Nuyens D, Theilmeier G, Creemers E, Moons L,Dyspersin GD, Cleutjens JPM, Shipley M, Angelillo A, Levi M, Nüsse O, Baker A, Keshet E, Lupu F, Herbet JM, Smits JFM, Shapiro SD, Baes M, Borgers M, Collen D, Daemen MJAP, Carmeliet P. Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure. Nat Med. 1999; 5: 1135-42.

• Angelillo-Scherrer A, de Frutos P, Aparicio C, Melis E, Savi P, Lupu F, Arnout J, DewerchinM, Hoylaerts MF, Herbert JM, Collen D, Dahlbäck B, Carmeliet P. Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis. Nat Med. 2001; 7: 215-21.

• Luttun A, Tjwa M, Moons L, Wu Y, Angelillo-Scherrer A., Liao F, Nagy JA, Hooper A, Priller J, De Klerck B, Compernolle V, Daci E, Molinas CR, Koninckx P, Bohlen P, Dewerchin M, Herbert JM, Fava R, Matthys P, Carmeliet G, Collen D, Dvorak HF, Hicklin DJ, Carmeliet P. PlGF and its receptor Flt-1 targets to treat angiogenesis and inflammatory diseases. Nat Med. 2002; 8: 831-840.

• Angelillo-Scherrer A, Burnier L, Flores N, Savi P, DeMol M, Schaeffer P, Herbert JM, Lemke G, Goff SP, Matsushima GK, Earp HS, Hoylaerts MF, Plaisance S, Conway EM, Collen D, Wehrle-Haller B, Carmeliet P. Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J Clin Invest. 2005; 115: 237-46.

• Angelillo-Scherrer A, Burnier L, Lambrechts D, Fish RJ, Tjwa M, Plaisance S, Lambrechts D, DeMol M, Martinez-Soria E, Flores N, Maxwell P, Lemke G, Goff SP, Matsushima GK, Earp HS, CollenD, Izui S, Conway EM, Carmeliet P. Role of Gas6 in erythropoiesis and anemia in mice, J Clin Invest. 2008; 118: 583-96.

• Saller F, Brisset AC, Tchaikovski SN, Azevedo M, Chrast R, Fernandez JA, Schapira M, Hackeng TM, Griffin JH, Angelillo-Scherrer A. Generation and phenotypic analysis of protein S-deficient mice. Blood. 2009; 114: 2307-14.

• Cosemans JM, Van Kruchten R, Olieslagers S, Schurgers LJ, Verheyen FK, Munnix IC, Waltenberger J, Angelillo-Scherrer A, Hoylaerts MF, Carmeliet P, Heemskerk JW. Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization. J Thromb Haemost. 2010; 8: 1797-808.

• Burnier L, Saller F, Kadi L, Brisset AC, Sugamele R, Baudino L, Bono F, Herbert JM, Carmeliet P, Schapira M, Izui S, Angelillo-Scherrer A. Gas6 deficiency in recipient mice of allogeneic transplantation alleviates hepatic graft-versus-host disease. Blood. 2010; 115: 3390-3397.

• Angelillo-Scherrer A, Fontana P, Burnier L, Roth I, Sugamele R, Brisset, A, Morel S, Nolli S, Sutter E, Chassot A, Capron C, Borgel D, Saller F, Chanson M, Kwak BR. Connexin37 limits thrombus propensity by downregulating platelet reactivity. Circulation. 2011. 124: 930-939.

As principal investigator:

• Role of growth arrest-specific gene 6 and protein S in hemostasis, thrombosis & inflammation

• Role of the gap junction Connexin37 in hemostasis & thrombosis

• Blocking protein S to treat hemophilia

As co-investigator:

• The swiss venous thromboembolism cohort 65+ (supported by the Swiss National Foundation for Scientific Research, principal investigator: Prof. D. Aujesky, University of Berne)

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