Short CV/Education and training

  • 1997
    PhD in Natural Sciences, Stockholm University

  • 1999 – 2001
    Postdoctor, Prof. Kim Nasmyth?s group. Research Institute for Molecular Pathology (IMP), Vienna, Austria.

  • 2001 – 2002
    Guest researcher, Södertörn University

  • since 2002
    Group leader at CMB, Karolinska Institutet. Present Group: 3 Post Doctors, 4 PhD students

  • since 2005
    Vice chairman CMB

  • since 2010
    Professor in Cell and Tumour Biology

  • 2008 – 2011
    Member of SFBM steering group

  • since 2012
    Member of the Karolinska Institutet?s Board of Research

Selected publications

  • Carter Dewey S. and Sjögren C.: The SMC complexes, DNA and chromosome topology ? right or knot? Invited review. Crit. Rev. Biochem. Betts Lindroos H., Ström. L., Itoh T., Katou, Y., Shirahige K., and Sjögren C. Chromosomal association of the Smc5/6 complex reveals that it functions in differently regulated pathways. Mol. Cell, 2006 (June 23), 22; 755- 767.

    This publication presents the first steps towards an identification of a non-repair function of the Smc5/6 complex.

  • Ström L., Karlsson C., Betts Lindroos H., Wedahl S., Katou Y., Shirahige K., Sjögren C. Post-replicative formation of cohesion is required for repair and induced by a single DNA break. Science, 2007; 317; 242-245.

    This article presents results showing that DNA damage induces a signalling cascade which trigger de novo formation of sister chromatid cohesion in post-replicative cells. This contradicted the then current idea that genome-wide cohesion only was created in connection to the replication fork.

  • Kegel A. and Sjögren C. The Smc5/6 complex – more than repair? Cold Spring Harb Symp Quant Biol. 2010;75:179-87.

    In this review we present and discuss the accumulating evidence for a non-repair function of Smc5/6 complex. This function has since 2007 been one of the main objects of investigations in my research team.

  • Kegel A., Betts-Lindroos H., Kanno K., Jeppsson K., Ström L.,Katou Y., Itoh T., Shirahige S., Sjögren C. Chromosome length influences replication-induced topological stress. Nature, 2011; 471; 392-396.

    This article presents our continued analysis of the Smc5/6 complex which indicated that replication-induced supercoiling is diffusible over chromosome ends. This was contrary to then current idea that supercoiling was confined to smaller chromosomal domains.

  • Carter Dewey S. and Sjögren C. The SMC complexes, DNA and chromosome topology –right or knot? Invited review. Crit. Rev. Biochem. Mol. Biol. 2012; 47;1-16

    Here we present and discuss observations which indicate that SMC complexes control, and are controlled by, DNA supercoiling.

  • Lilienthal I, Kanno T, Sjögren C. Inhibition of the Smc5/6 complex during meiosis perturbs joint molecule formation and resolution without significantly changing crossover or non-crossover levels. PLoS Genet., 2013; 9(11): e1003898. doi: 10.1371/journal.pgen.1003898.

    This article deals with the repair function of Smc5/6 and present results showing that the Smc5/6 complex controls the formation and/or resolution of recombination intermediates between sister chromatids during the meiotic cell cycle.

  • Jeppsson K., Carlborg K., Nakato R., Berta D., Lilienthal I., Kanno T., Lindqvist A., Brink M., Dantuma N., Katou Y., Shirahige K., Sjögren C. The Chromosomal Association of the Smc5/6 Complex Depends on Cohesion and Predicts the Level of Sister Chromatid Entanglement. PLoS Genet., 2014; doi: 10.1371/journal.pgen.1004680.

    In this article we show that the Smc5/6 complex preferentially associates to entangled sister chromatids and provide evidence that the level of entanglement is under control of replication-induced supercoiling.

  • Jeppsson K., Kanno T., Shirahige K., and Sjögren C. The maintenance of chromosome structure: positioning and function of SMC complexes. Invited review, Nat. Rev. Mol. Cell Biol. 2014; 15; 601-14

    In this overview of the field we present, compares and discusses the then current knowledge of the chromosomal association of different SMC complexes. The invitation to write this review indicates that the work from my laboratory is appreciated by the scientific community.

  • Kanno T., Berta D., Sjögren C. The Smc5/6 complex is an ATP-dependent intermolecular DNA linker. Cell reports, 2015, doi: 10.1016/j.celrep.2015.07.048.

    The presented biochemical and in vivo analysis provides the first detailed analysis of how the Smc5/6 complex binds DNA and chromosomes. It also and unravels a physical interaction between the complex and topoisomerase 2, thereby providing a direct connection between Smc5/6 complex and the regulation of DNA supercoiling and entanglement (by topoisomerase 2).

Selected projects

  • 35 international conferences

    Examples: EMBO workshops (7 times since 2010), EMBO conference, FASEB (twice since 2010), Keystone-, Gordon (twice since 2010) conferences, 3R meeting, Japan, twice since 2010), FEBS meeting (twice since 2010) and Cold Spring Harbour symposium. Sponsored by EMBO keynote lecture award twice, chair at ~10 occasions.

    36 research lectures

    Examples of inviting international institutes: Clare Hall Laboratories, Imperial College and London Research Institute, Grey Institute Oxford, Max-Planck Institute Martinsried,

    Curie Institute and Institute Jacques Monod, Sloan-Kettering Cancer Center, Nicholson lecture (Rockefeller), Friedrich Miescher Institute for Biomedical Research (Basel)

Membership in scientific bodies/juries

  • Member of Karolinska Institutet’s Board of Research, since 2012

  • Vice chairman CMB, since 2005

  • Member of Swedish Royal Academy of Sciences, Class of Medical Sciences, since 2013

  • Member of Swedish National committee for Molecular Biosciences, since 2009

  • Member of the Nobel Assemblym, since 2012

  • Adjunct member of Nobel committee, 2013 – 2015, 2017

  • Member of scientific advisory board for chromosome, since 2016

  • Evaluator of Ragnar Söderbergs Young Investigator grant applications, since 2014

  • Karolinska institutet Council for equal opportunities, 2012 – 2016

  • Evaluation of Swedish Cancer Foundation grant applications, 2009 – 2014

  • Panel vice chair 2011 – 2012, chair 2013 – 2014

  • Swedish Cancer Foundation, Board member, 2013 – 2016

  • Evaluator of European Research Council starting grant applications, 2009 – 2012

  • Panel vice chair, 2011 – 2012

  • Evaluator of Swedish Research Council grant applications, 2008

  • Divers appointments as evaluator, since 2011

  • Two professorships at Copenhagen University, Young research associates at Max Planck Institute, Wellcome Trust Grants, MRC grant, EMBO long term fellowships, Wallenberg Academy Fellow, Novo Nordisk Postdoctoral positions at KI

  • Assigned reviewer of manuscripts, since 2007

  • Science, EMBO reports, EMBO Journal, Molecular Cell, Current Biology, Genes and Development, Nucleic Acid Research, Nature Cell Biology,

    Journal of Clinical Investigations, PLOS Biology, PLOS Genetics, Current Biology, Journal of Molecular Biology, and others Co-organiser of Abcam conference Chromatin Replication and Chromosomal stability” in 2011 and 2013, of Nobel conference “Chromosome segregation and

    human disease“, 2003

  • Assigned faculty opponent, PhD defences, 2011 and 2015, Århus (2011) Copenhagen (2015), and Amsterdam (2015) Universities

  • Member of evaluation committee at 17 PhD-defences, since 2010, (at KI, Stockholm and Umeå Universities), 2 Licentiate –,and approximately 2 PhD half-time examinations per year

Soft Skills/Other activities and achievements

Other activities and achievements/family

  • Married, three children born 1996, 1998 and 2001


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