Short CV/Education and training

  • Christine Desmedt received her bio-engineer degree in Cells and Genes Biotechnology from the KU Leuven in 2000.

  • In September 2000, she started working at the Jules Bordet Institute, Brussels, an autonomous comprehensive cancer center devoted entirely to the fight against cancer. For two years, she worked as a clinical monitor for the Breast European Adjuvant Studies Group (Br.E.A.S.T), coordinating the monitoring activities of external groups for the conduct of breast cancer trials. This experience gave her the necessary clinical background for carrying optimal translational breast cancer research.

  • In 2003, she joined the Breast Cancer Translational Research Laboratory of this Institute, headed by Prof. Christos Sotiriou, where she started a PhD entitled “Multimarker approach for improving breast cancer treatment tailoring” with Prof. Martine Piccart as co-promoter.

  • In 2004, she earned a master in bio-medical sciences at the Université Libre de Bruxelle (U.L.B.) and defended successfully her PhD in 2008. Until 2018, she acted as the Translational Research Coordinator of the lab, conducting research projects and assisting the head of the lab in the scientific and administrative management of the lab.

  • From October 2010 till April 2011, she was a visiting scientist at the Wellcome Trust Sanger Institute, Hinxton, UK, under the supervision of Dr. P. Campbell in the Cancer Genome Project lab. This allowed her to have a detailed introduction to next generation sequencing and to develop important collaborations in the field of genomics and cancer.

  • In October 2018, Christine Desmedt was appointed as Assistant Professor at the Katholieke Universiteit Leuven (KU Leuven, Leuven), where she is heading the Laboratory for Translational Breast Cancer Research. The main research areas of the Lab are the unraveling of metastatic progression, the better understanding of rarer cancer subtypes such as lobular and mucinous breast tumors, the identification of mechanisms of treatment efficacy and the impact of patient adiposity on breast cancer biology.

  • She is also the co-leader of the Breast Cancer group of the Leuven Cancer Institute (LKI) with Prof. Dr. Hans Wildiers. She is also co-developer and co-leader of the breast cancer research autopsy program at UZ/KU Leuven with Prof. Dr. Giuseppe Floris. Prof. Desmedt is very active in lobular breast cancer research. She is the co-coordinator of the European Lobular Breast Cancer Consortium ( together with Prof. P. Derksen (University of Utrecht, The Netherlands) and Prof. Dr. A. Salomon (Institut Curie, Paris, France), and the vice-president of the COST Action CA 19138 LOBSTERPOT, entirely devoted to lobular breast cancer research. She is also co-coordinator of the Doctoral School Cancer at the KU Leuven.

Selected publications

  • Pate L, Desmedt C, Metzger O, Burgess Hutcheson L, Turner C, Freeney S, Oesterreich S. How Researchers, Clinicians and Patient Advocates Can Accelerate Lobular Breast Cancer Research. Cancers (Basel). 2021 Jun 22;13(13):3094. Doi: 10.3390/cancers13133094.

  • Floris G, Richard F, Hamy AS, Jongen L, Wildiers H, Ardui J, Punie K, Smeets A, Berteloot P, Vergote I, De Croze D, Meseure D, Salomon A, Laé M, Reyal F, Biganzoli E, Neven P, Desmedt C. Body Mass Index and Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer. J Natl Cancer Inst. 2021 Feb 1;113(2):146-153. Doi: 10.1093/jnci/djaa090.

  • Richard F, Majjaj S, Venet D, Rothé F, Pingitore J, Boeckx B, Marchio C, Clatot F, Bertucci F, Mariani O, Galant C, Eynden GVD, Salgado R, Biganzoli E, Lambrechts D, Vincent-Salomon A, Pruneri G, Larsimont D, Sotiriou C, Desmedt C. Characterization of Stromal Tumor-infiltrating Lymphocytes and Genomic Alterations in Metastatic Lobular Breast Cancer. Clin Cancer Res. 2020 Dec 1;26(23):6254-6265. Doi: 10.1158/1078-0432.CCR-20-2268.

  • Desmedt C, Fornili M, Clatot F, Demicheli R, De Bortoli D, Di Leo A, Viale G, de Azambuja E, Crown J, Francis PA, Sotiriou C, Piccart M, Biganzoli E. Differential Benefit of Adjuvant Docetaxel-Based Chemotherapy in Patients With Early Breast Cancer According to Baseline Body Mass Index. J Clin Oncol. 2020 Sep 1;38(25):2883-2891. Doi: 10.1200/JCO.19.01771.

  • Comprehensive evaluation of methods to assess overall and cell-specific immune infiltrates in breast cancer. Nederlof I, De Bortoli D, Bareche Y, Nguyen B, de Maaker M, Hooijer GKJ, Buisseret L, Kok M, Smid M, Van den Eynden GGGM, Brinkman AB, Hudecek J, Koster J, Sotiriou C, Larsimont D, Martens JWM, van de Vijver MJ, Horlings HM, Salgado R, Biganzoli E, Desmedt C. Breast Cancer Res. 2019 Dec 26;21(1):151. Doi: 10.1186/s13058-019-1239-6.

  • Nguyen B, Veys I, Leduc S, Bareche Y, Majjaj S, Brown DN, Boeckx B, Lambrechts D, Sotiriou C, Larsimont D, Desmedt C.D: 31878981 Free PMC article. Genomic, Transcriptomic, Epigenetic, and Immune Profiling of Mucinous Breast Cancer. J Natl Cancer Inst. 2019 Jul 1;111(7):742-746. Doi: 10.1093/jnci/djz023.

  • Desmedt C, Demicheli R, Fornili M, Bachir I, Duca M, Viglietti G, Berlière M, Piccart M, Sotiriou C, Sosnowski M, Forget P, Biganzoli E. Potential Benefit of Intra-operative Administration of Ketorolac on Breast Cancer Recurrence According to the Patient's Body Mass Index. J Natl Cancer Inst. 2018 Oct 1;110(10):1115-1122. Doi: 10.1093/jnci/djy042.

  • Desmedt C, Salgado R, Fornili M, Pruneri G, Van den Eynden G, Zoppoli G, Rothé F, Buisseret L, Garaud S, Willard-Gallo K, Brown D, Bareche Y, Rouas G, Galant C, Bertucci F, Loi S, Viale G, Di Leo A, Green AR, Ellis IO, Rakha EA, Larsimont D, Biganzoli E, Sotiriou C. Immune Infiltration in Invasive Lobular Breast Cancer. J Natl Cancer Inst. 2018 Jul 1;110(7):768-776. Doi: 10.1093/jnci/djx268.

  • Brown D, Smeets D, Székely B, Larsimont D, Szász AM, Adnet PY, Rothé F, Rouas G, Nagy ZI, Faragó Z, Tőkés AM, Dank M, Szentmártoni G, Udvarhelyi N, Zoppoli G, Pusztai L, Piccart M, Kulka J, Lambrechts D, Sotiriou C, Desmedt C. Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations. Nat Commun. 2017 Apr 20;8:14944. Doi: 10.1038/ncomms14944.

  • Desmedt C, Zoppoli G, Gundem G, Pruneri G, Larsimont D, Fornili M, Fumagalli D, Brown D, Rothé F, Vincent D, Kheddoumi N, Rouas G, Majjaj S, Brohée S, Van Loo P, Maisonneuve P, Salgado R, Van Brussel T, Lambrechts D, Bose R, Metzger O, Galant C, Bertucci F, Piccart-Gebhart M, Viale G, Biganzoli E, Campbell PJ, Sotiriou C. Genomic Characterization of Primary Invasive Lobular Breast Cancer. J Clin Oncol. 2016 Jun 1;34(16):1872-81. Doi: 10.1200/JCO.2015.64.0334. Epub 2016 Feb 29.

Complete list of publications

Selected projects

  • UPTIDER: UZ/KU Leuven Program for Post-mortem Tissue Donation to Enhance Research

  • FATLAS: Comprehensive Multi-level Characterization of Systemic and Mammary Adiposity in Breast Cancer Patients

Soft Skills/Other activities and achievements

Other activities and achievements/family

  • Family: 3 kids

  • Hobbies: sport and nature


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