Prof. Cosima T. Baldari

• 1972 – 1976
  Doctoral graduation with honors in Biological Sciences, University of Rome, Italy
  
  

• 1974 – 1976
  Experimental thesis work in Molecular Biology, Centro Acidi Nucleici CNR, Rome
  
  

• 1976
  Course in Marine Biology, Station Biologique (Faculté de Sciences, Paris VI) Roscoff, France
  
  

• 1976 – 1978
  Post-doctoral research associate, Centro Acidi Nucleici CNR, Rome, Italy
  
  

• 1977
  EMBO course "Electron microscopy of nucleic acids", EMBL, Heidelberg, Germany
  
  

• 1978 – 1980
  Post-doctoral long-term EMBO fellow, EMBL, Heidelberg
  
  

• 1981 – 1986
  Staff scientist, Department of Genetics and Molecular Biology University of Rome "La Sapienza"
  
  

• 1983
  Visiting scientist, EMBL, Heidelberg
  
  

• 1987
  EMBO course "Antibodies in cell biology", EMBL, Heidelberg
  
  

• 1986 – 1998
  Staff scientist, Department of Evolutionary Biology University of Siena, Italy
  
  

• 1998 – 2000
  Associate Professor of Molecular Biology, University of Siena
  
  

• since 2000
  Full Professor of Molecular Biology, University of Siena
  
  

• 2009 – 2012
  Chair of the Department of Evolutionary Biology, University of Siena
  
  

• since 2009
  Member of the Academic Senate of the University of Siena
  
  

• since 2012
  Chair of the Department of Life Sciences, University of Siena
  
  

• Boncristiano M, Rossi Paccani S, Barone S, Ulivieri C, Patrissi L, Ilver D, Amedei A, D'Elios MM, Telford JL, Baldari CT. (2003). The Helicobacter pylori vacuolating toxin inhibits T-cell activation by two independent mechanisms. J Exp Med 198, 1887-1897.

  Rossi Paccani S, Tonello F, Ghittoni R, Natale M, Muraro L, D'Elios MM, Tang W-J, Montecucco C, Baldari CT. (2005). Anthrax toxins suppress T-lymphocyte activation by disrupting antigen receptor signaling. J Exp Med 201, 325-331.

• Rossi Paccani S, Boncristiano M, Patrussi L, Ulivieri C, Wack A, Valensin S, Hirst TR, Amedei A, Del Prete G, Telford JL, D'Elios MM, Baldari CT. (2005). Defective Vav expression and impaired F-actin reorganization in a subset of common variable immunodeficiency patients with T-cell defects. Blood 106, 626-634.

• Patrussi L, Ulivieri C, Lucherini OM, Rossi Paccani S, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT. (2007). p52Shc is required for CXCR4-dependent signaling and chemotaxis in T-cells. Blood 110, 1730-1738.

• Finetti F, Pellegrini M, Ulivieri C, Savino MT, Paccagnini E, Ginnaneschi C, Lanfrancone L, Pelicci PG, Baldari CT. (2008). The proapoptotic and antimitogenic protein p66Shc acts as a negative regulator of lymphocyte activation and autoimmunity. Blood 111, 5017-5027.

• Rossi Paccani S, Benagiano M, Tonello F, Capitani N, Ladant D, Montecucco C, D'Elios MM, Baldari CT. (2009). The adenylate cyclase toxins of Bacillus anthracis and Bacillus pertussis promote Th2 cell differentiation by shaping T cell antigen receptor signaling. PLoS Path 5, e1000325. doi: 10.1371/journal.ppat.1000325

• Finetti F, Rossi Paccani S, Riparbelli MG, Giacomello E, Perinetti G, Pazour GJ, Rosenbaum J, Baldari CT. (2009). An intraflagellar transport component is required for polarized recycling of the TCR/CD3 complex to the immune synapse. Nat Cell Biol 11, 1332-1339.

• Capitani N, Lucherini OM, Sozzi E, Ferro M, Giommoni N, Finetti F, De Falco G, Cencini E, Raspadori D, Pelicci PG, Lauria F, Forconi F, Baldari CT. (2010). Impaired expression of p66Shc, a novel regulator of B-cell survival, in chronic lymphocytic leukemia. Blood 115, 3726-3736.

• Rossi Paccani S, Finetti F, Davi M, Patrussi L, D'Elios MM, Ladant D, Baldari CT. (2011). The adenylate cyclase toxin of Bordetella pertussis binds to T cells via the integrin LFA-1 and induces its disengagement from the immune synapse. J Exp Med 208, 131-1330.

• Capitani N, Patrussi L, Trentin L, Lucherini OM, Cannizzaro E, Migliaccio E, Frezzato F, Gattazzo C, Forconi F, Pelicci PG, Semenzato G, Baldari CT. (2012). S1P1 expression is controlled by the pro-oxidant activity of p66Shc and is impaired in B-CLL patients with unfavourable prognosis. Blood 120:4391-4399.

• Patrussi L, Capitani N, Martini V, Pizzi M, Trimarco V, Frezzato F, Semenzato G, Trentin L, Baldari CT. (2015). Enhanced chemokine receptor recycling and impaired S1P1 expression promote leukemic cell infiltration of lymph nodes in chronic lymphocytic leukemia (CLL). Cancer Res 75:4153-4163.

• Organizer of a EC COMET course "PCR technology and its applications". Siena, May 23-26 1994

• Organizer of the EMBO Workshop "Lymphocyte antigen receptor and coreceptor signaling", Siena, 1997, 1999, 2002, 2004

• Organizer of the EMBO Conference Series "Signaling in the immune system", Siena, 2007, 2009, 2011, 2014

• Expert evaluation research projects: EU FP4-7, EMBO, INTAS, Wellcome Trust, Austrian Science Fund, Israel Science Foundation, French National Research Agency, Portuguese Foundation for Science and Technology, Academy of Finland, Italian National Institute for Health, Italian Association for Cancer Research, Italian Ministry of University and Education, Italian National Research Council, Ateneo Italo-Tedesco

• Member Editorial Board European Journal of Immunology (1995-2005)

• Ad hoc reviewer for: Blood, Journal of Biological Chemistry, EMBO Reports, FEBS Letters, J. Cell. Physiol., Human Mutation, Tissue and Cell, Biochemical Pharmacology, PNAS USA, Oncogene, Brain Research, Molecular and Cellular Biology, The Journal of Experimental Medicine, The Journal of Immunology, The Journal of Clinical Investigation, PLoS Pathogens, Nature-AfCS Molecule Pages, Nature, Leukemia, Immunity.

• EMBO member

• Member SIBBM, and SIICA

• Member Italian Association for Cancer Research (AIRC) Scientific Board, member Regional AIRC Committee

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