Prof. Cosima T. Baldari

• Since 2012
  Chair of the Department of Life Sciences, University of Siena, Italy
  
  

• Since 2009
  Member of the Academic Senate of the University of Siena, Italy
  
  

• 2009 – 2012
  Chair of the Department of Evolutionary Biology, University of Siena, Italy
  
  

• Since 2000
  Full Professor of Molecular Biology, University of Siena, Italy
  
  

• 1998 – 2000
  Associate Professor of Molecular Biology, University of Siena, Italy
  
  

• 1986 – 1998
  Staff scientist, Department of Evolutionary Biology University of Siena, Italy
  
  

• 1987
  EMBO course "Antibodies in cell biology", EMBL, Heidelberg, Germany
  
  

• 1983
  Visiting scientist, EMBL, Heidelberg, Germany
  
  

• 1981 – 1986
  Staff scientist, Department of Genetics and Molecular Biology University of Rome "La Sapienza", Rome, Italy
  
  

• 1978 – 1980
  Post-doctoral long-term EMBO fellow, EMBL, Heidelberg, Germany
  
  

• 1977
  EMBO course "Electron microscopy of nucleic acids", EMBL, Heidelberg, Germany
  
  

• 1976 – 1978
  Post-doctoral research associate, Centro Acidi Nucleici CNR, Rome, Italy
  
  

• 1976
  Course in Marine Biology, Station Biologique (Faculté de Sciences, Paris VI) Roscoff, France
  
  

• 1974 – 1976
  Experimental thesis work in Molecular Biology, Centro Acidi Nucleici CNR, Rome, Italy
  
  

• 1972 – 1976
  Doctoral graduation with honors in Biological Sciences, University of Rome, Italy
  
  

• CAPITANI N, ONNIS A, FINETTI F, CASSIOLI C, PLEBANI A, BRUNETTI J, TROILO A, D'ELIOS S, BARONIO M, GAZZURELLI L, DELLA BELLA C, BILLADEAU D, D'ELIOS MM, LOUGARIS V, BALDARI CT. A CVID-associated variant in the ciliogenesis protein CCDC28B disrupts immune synapse assembly. Cell Death Differ, 2021 Jul 22. Doi: 10.1038/s41418-021-00837-5. Online ahead of print.

• CASSIOLI C, ONNIS A, FINETTI F, CAPITANI N, BRUNETTI J, COMPEER EB, NIEDERLOVA V, STEPANEK O, DUSTIN ML, BALDARI CT (2021). The Bardet-Biedl Syndrome complex component BBS1 controls T cell polarity during immune synapse assembly. J Cell Sci 134, jcs258462. Doi: 10.1242/jcs.258462.

• PATRUSSI L, MANGANARO N, CAPITANI N, TATANGELO V, LIBONATI F, FINETTI F, FREZZATO F, VISENTIN A, D'ELIOS MM, TRENTIN L, SEMENZATO G, BALDARI CT (2020) Enhanced IL-9 secretion by p66Shc-deficient CLL cells modulates the chemokine landscape in the stromal microenvironment. Blood 137, 2182-2195.

• FINETTI F, CASSIOLI C, CIANFANELLI V, ONNIS A, PACCAGNINI E, KABANOVA A, BALDARI CT (2020). The intraflagellar transport protein IFT20 controls lysosome biogenesis by regulating the post-Golgi transport of acid hydrolases. Cell Death Differ 27, 310-328.

• ONNIS A, CIANFANELLI V, CASSIOLI C, PELICCI OG, CECCONI F, BALDARI CT (2018). The pro-oxidant adaptor p66Shc promotes B cell mitophagy by disrupting mitochondrial integrity and recruiting LC3-II. Autophagy 14, 2117-2138.

• PATRUSSI L, CAPITANI N, CATTANEO F, MANGANARO N, GAMBERUCCI A, FREZZATO F, MARTINI V, VISENTIN A, PELICCI PG, D'ELIOS MM, TRENTIN L, SEMENZATO G, BALDARI CT. (2018). p66Shc deficiency promotes B cell chemotaxis by enhancing CXCR4 and CCR7 recycling in chronic lymphocytic leukemia. Oncogene 37, 1534-1550.

• GALGANO D, ONNIS A, PAPPALARDO E, GALVAGNI F, ACUTO O, BALDARI CT. (2017). The T cell IFT20 interactome reveals new players in immune synapse assembly. J Cell Sci 130:1110-1121.

• KABANOVA A, SANSEVIERO F, CANDI V, GOZZETTI A, BOCCHIA M, BALDARI CT (2016). Non-lytic degranulation of CD8+ cytotoxic T lymphocytes. Cell Rep 15, 9-18.

• VIVAR OI, MASI G, CARPIERJM, MAGALHAES J, GALGANO D, PAZOUR GJ, AMIGORENA S, HIVROZ C, BALDARI CT. (2016). IFT20 controls LAT recruitment to the immune synapse and T cell responses in vivo. Proc Natl Acad Sci USA 113, 386-91.

• PATRUSSI L, CAPITANI N, MARTINI V, PIZZI M, TRIMARCO V, FREZZATO F, SEMENZATO G, TRENTIN L, BALDARI CT. (2015). Enhanced chemokine receptor recycling and impaired S1P1 expression promote leukemic cell infiltration of lymph nodes in chronic lymphocytic leukemia (CLL). Cancer Res 75, 4153-4163.

• Organizer of a EC COMET course "PCR technology and its applications". Siena, May 23-26 1994

• Organizer of the EMBO Workshop "Lymphocyte antigen receptor signaling", Siena, 1997, 1999, 2002, 2004, 2007, 2009, 2011, 20134, 2016, 2018, 2020 (re-scheduled to 2022 due to COVID pandemic)

• Organizer of the EMBO Conference Series "Signaling in the immune system", Siena, 2007, 2009, 2011, 2014

• EMBO member

• Italian Representative for Horizon 2020, ERC program

• Member Academianet (Network Leading Women Scientists)

• Member Scientific Advisory Board Pompeu Fabra University (Barcelona, Spain)

• Member EMBO Global Investigator Network committee

• Panel Member ERC Consolidator Grants, 2022

• Member Top Italian Scientists

• Member Italian Association for Cancer Research (AIRC) Scientific Board, 2008 – 2017

• Member Italian Society for Biochemistry & Molecular Biology (SIBBM), Italian Society for Immunology, Clinical Immunology and Allergology (SIICA), European Cell Death Organization (ECDO)

• Member Editorial Board Nature Scientific Reports

• Associate Member Frontier in Immunology (T cell biology)

• Review Editor Frontiers in Immunology

• Member Editorial Board European Journal of Immunology (1995 – 2005)

• Ad hoc reviewer for peer reviewed journals, including Nature, Nature Medicine, Nature Communications, Leukemia, Immunity, PNAS USA, Journal of Experimental Medicine, Journal of Cell Biology, Science Immunology, Science SIgnaling, Cell Reports, Journal of Immunology, Journal of Cell Science, Journal of Clinical Investigation, PLoS Pathogens, Cancer Research, Oncogene, Blood, Nature Scientific Reports, Journal of Biological Chemistry, Autophagy, EMBO Reports, Frontiers in Immunology, Molecular and Cellular Biology, FEBS Letters

Soft Skills

• Expert evaluation research projects EU FP4-7, ERC, EMBO, INTAS, American Institute for Cancer Research (AICR), French Agence Nationale pour la Recherce (ANR), Deutsche Forschung Gemeinschaft (DFG), Food & Drug Administration (FDA), Human Frontier Science Program (HFSP), Wellcome Trust, Austrian Science Fund (FWF), Israel Science Foundation (ISF), Finnish Academy of Sciences, Czech Science Foundation, Portuguese Foundation for Science and Technology, Netherlands Organisation for Scientific Research (NWO), Health Research Board Ireland, Kennedy Trust for Rheumatology Research, AIRC, ISS, MIUR, CNR, Ateneo Italo-Tedesco

• Expert for career assessment University of Washington School of Medicine (USA), University of Lausanne (Switzerland), Institut Pasteur (France), FDA (USA)

• Expert for Full Professor recruitment at University of Freiburg (Germany)

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