Short CV/Education and training

  • Since 2014
    Head of Department for “Computational Biology for Infection Research” at the Helmholtz Centre for Infection Research (HZI) and full professor, Carl-Friedrich-Gauss Department and Department of Life Sciences, Technical University of Braunschweig, Germany

  • 2004
    Doctoral dissertation: Gene finding and the evaluation of synonymous codon usage features in microbial genomes

  • 2000
    Diplom degree in Biochemistry

  • 1995 – 2000
    Studied Biochemistry, Department of Chemistry, Bielefeld University, Germany

  • 1995
    Abitur (A-levels), Schönbuch Gymnasium (grammar school), Holzgerlingen, Baden-Württemberg, Germany

Selected publications

  • A. C. McHardy, H. G. Martin, A. Tsirigos, P. Hugenholtz, I. Rigoutsos, Accurate phylogenetic classi-fication of variable-length DNA fragments. Nat Methods 2007, 4: 63-72.

  • K. R. Patil, P. Haider, P. B. Pope, P. J. Turnbaugh, M. Morrison, T. Scheffer, A. C. McHardy, Taxo-nomic metagenome sequence assignment with structured output models. Nat Methods 2011, 8:191-2.

  • D. Bulgarelli, R. Garrido-Oter, P. C. Munch, A. Weiman, J. Droge, Y. Pan, P. Schulze-Lefert¶, A. C. McHardy¶, Structure and function of the bacterial root microbiota in wild and domesticated bar-ley. Cell Host Microbe 17, 392-403 (2015). ¶ Shared last authors.

  • Y. Bai, D. B. Muller, G. Srinivas, R. Garrido-Oter, E. Potthoff, M. Rott, N. Dombrowski, P. C. Munch, S. Spaepen, M. Remus-Emsermann, B. Huttel, A. C. McHardy, J. A. Vorholt, P. Schulze-Lefert, Func-tional overlap of the Arabidopsis leaf and root microbiota. Nature 2015, 528: 364-9.

  • S. Hacquard, R. Garrido-Oter, A. Gonzalez, S. Spaepen, G. Ackermann, S. Lebeis, A. C. McHardy, J. L. Dangl, R. Knight, R. Ley, P. Schulze-Lefert, Microbiota and Host Nutrition across Plant and Animal Kingdoms. Cell Host Microbe 17, 603-16 (2015).

  • A. Weimann, K. Mooren, J. Frank, P.B. Pope, A. Bremges, A.C. McHardy

    From Genomes to Phenotypes: Traitar, the Microbial Trait Analyzer.

    mSystems 2016, 1: e00101.

  • A. Sczyrba*, P. Hofmann*, P. Belmann*, D. Koslicki, S. Janssen, J. Droge, I. Gregor, S. Majda, J. Fiedler, E. Dahms, A. Bremges, A. Fritz, R. Garrido-Oter, T. Sparholt Jorgensen, N. Shapiro, P. D. Blood, A. Gurevich, Y. Bai, D. Turaev, M. Z. DeMaere, R. Chikhi, N. Nagarajan, C. Quince, F. Meyer, Monika Balvočiūtė, L. H. Hansen, S. J. Sorensen, B. K. H. Chia, B. Denis, J. L. Froula, Z. Wang, R. Egan, D. D. Kang, J. J. Cook, C. Deltel, M. Beckstette, C. Lemaitre, P. Peterlongo, G. Rizk, D. Lavenier, Y.-W. Wu, S. W. Singer, C. Jain, M. Strous, H. Klingenberg, P. Meinicke, M. Barton, T. Lingner, H.-H. Lin, Y.-C. Liao, G. Gueiros Z. Silva, D. A. Cuevas, R. A. Edwards, S. Saha, V. C. Piro, B. Y. Renard, M. Pop, H.-P. Klenk, M. Goker, N. Kyrpides, T. Woyke, J. A. Vorholt, P. Schulze-Lefert, E. M. Rubin, A. E. Darling, T. Rattei, A. C. McHardy Critical Assessment of Metagenome Interpretation − a benchmark of metagenomics software.

    Nat Methods 2017, 14: 1063.

  • E. Asgari, P. C. Munch, T. R. Lesker, A. C. McHardy*, M. R. K. Mofrad* (*shared last authors)

    DiTaxa: Nucleotide-pair encoding of 16S rRNA for host phenotype and biomarker detection. Bio-informatics 2018, Epub: bty954.

  • F. Meyer, A. Bremges, P. Belmann, S. Janssen, A. C. McHardy*, D. Koslicki* (*shared last authors)

    Assessing taxonomic metagenome profilers with OPAL.

    Genome Biol 2019, 20:51.

  • A. Fritz, P. Hofmann, S. Majda, E. Dahms, J. Droge, J. Fiedler, T. R. Lesker, P. Belmann, M. Z. DeMae-re, A. E. Darling, A. Sczyrba, A. Bremges, A. C. McHardy. CAMISIM: simulating metagenomes and microbial communities. Microbiome 2019, 7:17.

Complete list of publications

Selected projects

  • Principal Investigator and consortium coordinator: DZIF-IT Platform TI BBD, iDeEx, GirOD, 2021

  • Co-Principal Investigator and consortium coordinator: NFDI4Microbiota, 2021

  • Co-Principal Investigator: Proof of concept study of a SARS-COV-2 vaccine based on recombinant spike protein, 2020

  • Principal Investigator and consortium coordinator: Rational design of a universal flu vaccine using recombinant neuraminidase (UVAC) – Bill and Melinda Gates Foundation, 2019

  • Co-Princicipal Investigator: Paving the way towards individualized vaccination (i.Vacc) – Exploring multi-omics Big Data in the general population based on a digital mHealth cohort – Volkswagen Stiftung, 2019

  • Principal Investigator: Drug discovery and cheminformatics for new anti-infectives (iCA) – Lower Saxony Doctoral Program, 2019

Membership in scientific bodies/juries

  • Member of the recruitment committee for a junior research group at the Max Planck Institute for Molecular Biomedicine, 2010

  • Member of the programme committee for the 18th Conference on Intelligent Systems for Molecular Biology (ISMB 2010), 9th European Conference on Computational Biology (ECCB 2010), 2010

  • Member of the committee "Centrally Announced Group", one of the types of Max Planck Research Groups, 2009/2010

Media coverage

  • News article on ZDF Heute: Umgang mit Mutanten – Das Coronavirus lässt sich kalkulieren (How to handle mutant viruses. The corona virus can be controlled.), 2021

  • Interview with Nachtjournal RTl – Impfstoff und Mutanten (vaccines and mutant virus), 2021

Additional qualifications

  • Scientific advisor for the European Union Seventh Framework Programme for Research and Technological Development, for the German Research Foundation (DFG) and for the Austrian Academy of Sciences

  • Scientific reviewer for Bioinformatics, BMC Bioinformatics, Environmental Microbiology, FEMS Microbiology Letters, Genome Research, Genomics, Infection, Genetics and Evolution, IEEE/ACM Transactions on Computational Biology and Bioinformatics, Journal of Theoretical Biology, Journal of Virology, Nature Methods, Nucleic Acids Research, Molecular Biology and Evolution, Intelligent Systems for Molecular Biology (ISMB), European Conference on Computational Biology (ECCB) and the Annual International Conference on Research in Computational Molecular Biology (RECOMB)


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