Prof. Dr. Anna Akhmanova
Biological and related sciences , Cell Biology, Molecular Biology, Biochemistry, Microscopy
Biological and related sciences
Molecular biology
Signal transduction, cancer research, oncology / tumour suppressor genetics, metabolism, cell growth, transcription
European Molecular Biology Organisation (EMBO) Young Investigator Award, 2000
EMBO Long-term fellowship, 1997 – 1999
English, German
Griffiths, B, Lewis, C.A., Bensaad, K., Ros, S., Zhang, Q., Ferber, E.C., Konisti, S., Peck, B., Miess, H., East. P., Wakelam, M., Harris, A.L., and Schulze, A. (2013) Inhibition of SREBP induces ER-stress by altering cellular lipid composition and blocks cancer cell growth. Cancer & Metabolism. 1:3
Schulze A, Harris AL. How cancer metabolism is tuned for proliferation and vulnerable to disruption. Nature 2012. 491(7424), 364-73.
Ros S, Santos CR, Moço S, Baenke F, Kelly G, Howell M, Zamboni N and Schulze A. (2012) Functional screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB4) as an important regulator of prostate cancer cell survival. Cancer Discovery 2:328-343
Ferber E, Peck B, Delpeuch EO, Bell G, East P and Schulze A. (2011) FOXO3A regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression. Cell Death and Differentiation. doi: 10.1038/cdd.2011.179
Porstmann, T. et al.: A new player in the orchestra of cell growth: SREBP activity is regulated by mTORC1 and contributes to the regulation of cell and organ size. In: Biochem Soc Trans 37, 2009. S. 278-283.
Porstmann, T. et al.: SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. In: Cell Metabolism 8(3), 2008. S. 224-236.
Delpuech, O. et al.: Induction of Mxi1-SRalpha by FOXO3a Contributes to Repression of Myc-Dependent Gene Expression. In: Mol Cell Biol. 27(13), 2007. S. 4917-4930.
Porstmann, T. et al.: PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. In: Oncogene 24(43), 2005. S. 6465-6581
Schulze, A. et al.: Analysis of the transcriptional program induced by Raf in epithelial cells. In: Genes and Development 15(8), 2001. S. 981-994.
Schulze, A. et al.: Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site. In: Proc. Natl. Acad. Sci. USA 92, 1995. S. 11264-11268.
Schulze, A., Downward, J.: Navigating gene expression with microarrays – a technology review. In: Nature Cell Biology 3, 2001. E190-195.
Information about my group’s research projects is available at: http://www.pch2.biozentrum.uni-wuerzburg.de/research_groups/ag_schulze/
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Biological and related sciences , Cell Biology, Molecular Biology, Biochemistry, Microscopy
Biological and related sciences , Microbial bioelectrochemistry, Microbial electrophysiology
Biological and related sciences , cell biology, molecular biology, biomedicine
Biological and related sciences , Evolutionary biology, Evolutionary genetics