Prof. Dr. Almut Schulze

• 1991 – 1992
  Diplom student, Institute for Biochemistry, Darmstadt University of Technology, Germany; research focus: Regulation of expression of the viral oncogenes of HPV16 by hormones
  
  

• 1992
  Diplom degree in biology, Darmstadt University of Technology
  
  

• 1992 – 1996
  Doctoral studies, Applied Tumour Virology, German Cancer Research Centre, Heidelberg
  
  

• 1996
  PhD in biology, Heidelberg University
  
  

• 1996
  Doctor of Natural Science (Dr. rer. nat.) from the Department of Biology at Heidelberg University
  
  

• 1996 – 1997
  Postdoctoral fellow, Applied Tumour Virology, German Cancer Research Centre, Heidelberg
  
  

• 1997 – 2002
  Postdoctoral fellow, Signal Transduction Laboratory, Imperial Cancer Research Fund, United Kingdom
  
  

• 2002 – 2013
  Staff Scientist and Group Leader, Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, United Kingdom
  
  

• Since 2014
  W2 professor in the independent research group (under a chair) working on biochemistry and molecular biology, Theodor Boveri Institute (Department of Biochemistry), Biocentre of the University of Würzburg
  
  

• Griffiths, B, Lewis, C.A., Bensaad, K., Ros, S., Zhang, Q., Ferber, E.C., Konisti, S., Peck, B., Miess, H., East. P., Wakelam, M., Harris, A.L., and Schulze, A. (2013) Inhibition of SREBP induces ER-stress by altering cellular lipid composition and blocks cancer cell growth. Cancer & Metabolism. 1:3

• Schulze A, Harris AL. How cancer metabolism is tuned for proliferation and vulnerable to disruption. Nature 2012. 491(7424), 364-73.

• Ros S, Santos CR, Moço S, Baenke F, Kelly G, Howell M, Zamboni N and Schulze A. (2012) Functional screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB4) as an important regulator of prostate cancer cell survival. Cancer Discovery 2:328-343

• Ferber E, Peck B, Delpeuch EO, Bell G, East P and Schulze A. (2011) FOXO3A regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression. Cell Death and Differentiation. doi: 10.1038/cdd.2011.179

• Porstmann, T. et al.: A new player in the orchestra of cell growth: SREBP activity is regulated by mTORC1 and contributes to the regulation of cell and organ size. In: Biochem Soc Trans 37, 2009. S. 278-283.

• Porstmann, T. et al.: SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. In: Cell Metabolism 8(3), 2008. S. 224-236.

• Delpuech, O. et al.: Induction of Mxi1-SRalpha by FOXO3a Contributes to Repression of Myc-Dependent Gene Expression. In: Mol Cell Biol. 27(13), 2007. S. 4917-4930.

• Porstmann, T. et al.: PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. In: Oncogene 24(43), 2005. S. 6465-6581

• Schulze, A. et al.: Analysis of the transcriptional program induced by Raf in epithelial cells. In: Genes and Development 15(8), 2001. S. 981-994.

• Schulze, A. et al.: Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site. In: Proc. Natl. Acad. Sci. USA 92, 1995. S. 11264-11268.

• Schulze, A., Downward, J.: Navigating gene expression with microarrays – a technology review. In: Nature Cell Biology 3, 2001. E190-195.

• Information about my group’s research projects is available at: http://www.pch2.biozentrum.uni-wuerzburg.de/research_groups/ag_schulze/

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