Prof. Dr. Miriam Agler-Rosenbaum
Biological and related sciences , Microbial bioelectrochemistry, Microbial electrophysiology
Forschungszentrum Translationale Neurowissenschaften (FTN) der Johannes Gutenberg-Universität Mainz
Biological and related sciences , Health
Cell Biology, Cellular and Molecular Neuroscience, Vascular Biology, Tumour Biology
Neurovascular link, Neurodevelopment, Developmental and pathological angiogenesis, Glioma invasion
Member of the German National Academy of Sciences Leopoldina, 2012
Gutenberg Forschungskolleg Fellowship, 2012
Paul Ehrlich and Ludwig Darmstädter Prize for Young Investigators, 2010
EU-fellowshipTraining and Mobility of Researchers (TMR Programme), 1996
Spanish Goverment PhD Fellowship (FPI Fellow), 1992
Ph.D. Extraordinary Award by Valencia University, 1997
English, German, Spanish
Senturk, A., Pfennig, S., Weiss, A., Burk, K. and Acker-Palmer, A. (2011) EphrinBs are essential components of the Reelin pathway to regulate neuronal migration. Nature, 472:356-60.
Sawamiphak, S., Seidel, S., Essmann, C.L., Wilkinson, G., Pitulescu, M.E., Acker, T. and Acker-Palmer, A. (2010) EphrinB2 regulates VEGFR2 function in developmental and tumour angiogenesis Nature 465, 487-491.
Essmann, C.L., Martinez, E., Geiger, J., Zimmer, M., Traut, M., Stein, V., Klein, R. and Acker-Palmer, A. (2008) Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors. Nature Neuroscience 11: 1035 – 1043.
Segura, I., Essmann, C. L., Weinges, S. and Acker-Palmer, A. (2007). Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation. Nature Neuroscience 10: 301-310.
Palmer, A. and Klein, R. (2003) Multiple roles of ephrins in morphogenesis, neuronal networking, and brain function. Genes & Development 17: 1429-1450.
Palmer, A., Zimmer, M., Erdmann, K.S., Eulenburg, V., Porthin, A., Heumann, R., Deutsch, U., and Klein, R. (2002). EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase. Molecular Cell 9: 725-37.
Palmer, A.; Gavin, A.C. and Nebreda,A.R. (1998) A link between MAP Kinase and p34cdc2/cyclinB during oocyte maturation: p90rsk associates with and phosphorylates the p34cdc2 inhibitory kinase Myt1 EMBO J., 17: 5037-5047.
Speaker GRADE-Brain (Goethe Graduate Academy), since 2012
Vice-speaker of the Rhine-Main Neuroscience Network (rmn2), since 2011
Vice-Speaker (Frankfurt coordinator) Collaborative Research Centre SFB1080 Molecular and Cellular Mechanisms of Neuronal Homeostasis Mainz/Frankfurt
Member of the Board of Directors Cluster of Excellence Macromolecular Complexes (CEF), 2009 – 2012
Board member of the LOEWE Focus project: Neuronal Coordination Frankfurt (NeFF)
Board member of the LOEWE Focus project: Ocogenic signal transduction Frankfurt (OSF)
Member of the German National Academy of Sciences Leopoldina
Member of the Gutenberg Forschungskolleg
Member of the American Society for Biochemistry and Molecular Biology (ASBMB)
Member of the German Neuroscience Society
Member of the German Society for Cell Biology
Member of the German Society for Biochemistry and Molecular Biology
Member of the Interdisciplinary Centre for Neuroscience Frankfurt (ICNF)
Member of the Center for Membrane Proteomics Frankfurt (CMP)
Member of the Cluster of Excellence Macromolecular Complexes (CEF)
Member of the Cluster of Excellence Cardio-Pulmonary System (ECCPS)
married, 2 children
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Biological and related sciences , Microbial bioelectrochemistry, Microbial electrophysiology
Biological and related sciences , Molecular biology, molecular microbiology, biochemistry, membrane protein biochemistry
Biological and related sciences , Evolution, genomics, bioinformatics
Biological and related sciences , cell biology, molecular biology, biomedicine
The growth of neuronal and vascular networks is controlled by the same molecules. Now Amparo Acker-Palmer plans to study the communication between neurons and blood vessels in the brain. She hopes to use her findings to gain important insights into dementia progression, and into other mental illnesses.
Healthy cells reduce their growth when there is a lack of oxygen, or hypoxia. But hypoxia is a characteristic of malignant tumours. The team of Prof. Amparo Acker-Palmer from Goethe University Frankfurt and colleagues from the University of Giessen could show how cancer cells succeed at circumventing the genetic program of growth inhibition.