Prof. Dr. Miriam Agler-Rosenbaum
Biological and related sciences, Microbial bioelectrochemistry, Microbial electrophysiology
Institute for Complex Molecular Systems, Eindhoven University of Technology, Netherlands
Biological and related sciences, Engineering and engineering trades , Health
Regenerative Medicine, Tissue Engineering, Mechanobiology
Cardiovascular regeneration, cardiac tissue, heart valves, vessels, extracellular matrix
My research concentrates on cell-matrix interactions in cardiovascular tissues, with special emphasis on regulating growth, differentiation, adaptation and remodeling for tissue regenerative purposes. I use "living" model systems at different length scales (cell, cell-matrix, engineered tissue, native tissue) to quantify and manipulate these aspects, preferably in a real-time and high-throughput fashion. Current research topics concern the biophysical (stem)cell niche, tissue engineered disease models, and restoring matrix architecture and mechanotransduction in compromised cardiovascular tissues.
Elected member of the Royal Netherlands Academy of Arts and Sciences (KNAW), 2017
Recipient of the national Gravitation Award for ‘Materials-Driven Regeneration (MDR)’ (a 25 MEuro grant program to spearhead a national programme on this topic), 2017
Elected member of the Royal Dutch Society of Sciences (KMHW), 2013
Founding fellow of the European Alliance for Medical and Biological Engineering and Science (EAMBES), 2012
Member of the Young Academy of the Royal Dutch Society of Arts and Sciences, 2005 – 2010
Vici Career Development award, Innovational Research Incentives, NWO, 2003
Aspasia Career Development award, Netherlands Organisation for Scientific Research (NWO), 2002
Dutch, English
Bax N.A.M. et al., Cardiomyocyte progenitor cells produce and remodel matrix during in vitro differentiation. J Mol Cell Cardiol 2012; DOI 10.1016/j.yjmcc.2012.07.003.
Fioretta ES, Fledderus J, Burakovska E, Baaijens FPT, Verhaar M, Bouten CVC. Polymer-based scaffold designs for in situ vascular tissue engineering: controlling recruitment and differentiation behavior of ECFCs. Macromol Biosci 2012;12: 577-590.
Van Geemen D, Driessen-Mol A, Grootzwagers LGM, Riem Vis PW, Baaijens FPT, Bouten CVC. Variation in tissue outcome of ovine and human engineered heart valve constructs: relevance for tissue engineering. Reg Med 2012;7: 59-70.
Bouten CVC, Dankers PYW, Driessen-Mol A, Pedron S, Brizard AM, Baaijens FPT. Substrates for cardiovascular tissue engineering. Adv Drug Deliv Rev. 2011;63(4-5): 221-241.
Riem Vis PW, Kluin J, Sluijter JPG, van Herwerden LA, Bouten CVC. Environmental regulation of valvulogenesis: implications for tissue engineering. Eur J CardioThoracic Surgery 2011;39(1): 8-17.
Balguid A, Mol A, van Vlimmeren MAA, Baaijens FPT, Bouten CVC. Hypoxia induced near-native mechanical properties of engineered heart valve tissue. Circulation 2009;119: 290-297.
Hjortnaes J, Bouten CVC, van Herwerden LA, Grundeman PM, Kluin J. Translating autologous heart valve tissue engineering form bench to bed. Tissue Engineering Part B Rev 2009;15(3): 307-317.
Rubbens MP, Mol A, Boerboom RA, Bank RA, Baaijens FPT, Bouten CVC. Intermittent straining accelerates the development of tissue properties in engineered heart valve tissue. Tissue Engineering Part A 2009;15(5): 999-1008.
Gawlitta D, Boonen KJM, Oomens CWJ, Baaijens FPT, Bouten CVC. The influence of serum-free culturing on skeletal muscle development in a tissue-engineered model. Tissue Engineering Part A 2008;1: 161-171.
Boerboom RA, Nash-Krahn K, Megens RTA, van Zandvoort MAMJ, Merkx M, Bouten CVC. High resolution imaging of collagen organization and synthesis using a versatile collagen specific probe. J Structural Biol 2007;159: 392-399.
www.tue.nl, research group: Soft tissue, biomechanics and tissue engineering
National Advisory Committee: ‘Covid and Trust in Research’, KNAW, NL, 2021
Audit Committee Medical Technology, National Institute Public Health & Environment, NL, 2021
Council for Medical Sciences, KNAW, NL, since 2020
Board member, Netherlands Organization for Health Research and Development (ZonMw), since 2020
Scientific Advisory Board, Institute of Bioengineering of Catalonia Barcelona, Spain, since 2019
Strategic Advisory Board, Regenerative Medicine Crossing Borders (RegMed-XB), NL, since 2019
Board of Directors, Int. Society of Applied Cardiovascular Biology, since 2017
Board of Directors, Secretary and Treasurer (since ’20), Heart Valve Society, since 2015
Scientific Advisory Board, Dutch Heart Foundation, NL, 2013 – 2019
Member of the national research assessment committees "Tissue Engineering?"(2006 – 2007) and "Regenerative Medicine" (2007 – 2010), under auspices of the Royal Dutch Society of Arts and Sciences
Am. Soc. Mech. Engineers (ASME); Eur. Soc. Biomechanics (ESB); Dutch Soc.Matrix Biol., since 1998
Task Force on Stem Cell Regeneration of the Heart, European Society of Cardiology; Am Soc Mech Engineers (ASME); Society of Heart Valve disease (SHVD); European Society of Biomechanics (ESB); Dutch Society of Matrix Biology
ZON-MW, STW, NHS, Echo (CW), Mosaik, Veni/Vidi schemes, various international grant schemes
One step closer to regenerative heart valves stents, Healthcare in Europe, 08-01-2021.
Regenerative heart valves blood vessels, article on medicaxpress.com, 07-01-2021.
Hoe ontstaat een levende hartklep? (How to build a living heart valve, (Huibregtsenprijs 2017), Current knowledge series
Research highlights ways to protect astronaut cardiovascular health from space radiation, article on Frontiers Science Communications
Instructive Supramolecular Scaffolds for In Situ Cardiovascular Tissue Engineering iValve animation, A.I.P.M. Smits, G. van Almen, K. Pieterse, P.Y.W.Dankers, C.V.C. Bouten
A new heart valve is made tightly in a mold in the body itself, Interview Omroep Brabant
'Powerful material’ – How can we build a living heart valve using plastic material?, 6 March 2019, Universiteit van Nederland, lecture
Zo Goed Als Nieuw, interactive e-book, NIRM
Leader of TU/e Strategic Area Health program "Smart Interventions", 2011 – 2020
Married, three children
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Biological and related sciences, Microbial bioelectrochemistry, Microbial electrophysiology
Biological and related sciences, Health, Cell Biology, Cellular and Molecular Neuroscience, Vascular Biology, Tumour Biology
Biological and related sciences, cell biology, molecular biology, biomedicine
Biological and related sciences, Health, Cell Biology, Cellular signaling, Cancer biology, Cancer therapy