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Physical sciencesBiopolymers, Fiber science
Biological and related sciences , HealthCell Biology, Cellular and Molecular Neuroscience, Vascular Biology, Tumour Biology
Caroline Kisker's research team from Würzburg, together with colleagues form Stony Brook University, have found a new weak spot in the bacterium that causes tuberculosis: blocking a specific enzyme involved in the cholesterol catabolism.
When discussing the dangers of antibiotic-resistant bacteria in hospitals, the name Staphylococcus aureus will almost certainly be mentioned. In search of new agents against this bacterium, one of the main targets is the enzyme FabI. It has now been characterized in detail by scientists from the Rudolf Virchow Center in Würzburg. They also found indications why Staphylococcus aureus is more susceptible to the blockage of this enzyme than other bacteria.
The plague is believed to have been eradicated in Europe. But it continues to reappear in other parts of the world. Since the pathogens are becoming resistant to the usual antibiotics, new agents are urgently needed. Progress has now been made.