Short CV/Education and training

  • Since 2020 Coordinator of ADDovenom consortium, funded by EC Horizon2020

  • Since 2018 Wellcome Trust Investigator

  • Since 2014 Professor of Biochemistry, University of Bristol (UK)

  • 2007 – 2016
    Team leader for cryo-electron microscopy at the European Molecular Biology Laboratory (EMBL)

  • 2006 – 2007
    Research associate and lecturer at the Institute of Molecular Biology and Biophysics (IMB), Swiss Federal Institute of Technology Zurich

  • 2001 – 2005
    Postdoc, IMB, Swiss Federal Institute of Technology Zurich

  • 1997 – 2001
    PhD studies, Institute of Biochemistry, University of Zurich

  • 1992 – 1997
    Studied biochemistry at Leibniz University Hanover (LUH), Medical University of Hanover (MHH), Germany, and Swiss Federal Institute of Technology Zurich, Switzerland

Selected publications

  • Toelzer, C., Gupta, K., Yadav, S.K.N., Borucu, U., Davidson, A.D., Williamson, M.K., Shoemark, D.K., Garzoni, F., Staufer, O., Milligan, R., Capin, J., Mulholland, A.J., Spatz, J., Fitzgerald, D., Berger, I. & Schaffitzel, C.* (2020) Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein. Science 370, 725-730. DOI: 10.1126/science.abd3255.

  • Powers, K.T., Stevenson-Jones, F.. Yadav, S.K.N., Amthor, B., Bufton, J., Borucu, U., Shen, D. , Becker, J., Larysh D., Hentze, M., Kulozik, A., Neu-Yilik, G. & Schaffitzel, C.* (2021) Blasticidin S inhibits peptide bond formation and release in mammalia and modulates translation dynamics at premature termination codons. Nucl. Acids Res. 49, 7665-7679. doi: 10.1093/nar/gkab532.

  • Eliseev, B., Yeramala, L., Leitner, A., Karuppasamy, M., Raimondeau, E., Huard, K., Alkalaeva, E., Aebersold, R. & Schaffitzel, C.* (2018) Structure of human cap-dependent 48S translation pre-initiation complex. Nucl. Acids Res. 46, 2678–2689.

  • Karuppasami, M., Kusminder, B., Oliveira, T.M., Gaubitz, C., Prouteau, M., Loewith, R.* & Schaffitzel, C.* (2017) Structure of the Saccharomyces cerevisiae Target of Rapamycin Complex 2. Nat. Commun. 8, 1729. DOI: 10.1038/s41467-017-01862-0.

  • Neu-Yilik, G., Raimondeau, E., Eliseev, B., Yeramala, L., Amthor, B., Deniaud, A., Huard, K., Kerschgens, K., Hentze, M.W.*, Schaffitzel, C.* & Kulozik, A. E.* (2017) Dual function of UPF3B in early and late translation termination. EMBO J. 36, 2968-2986. DOI:10.15252/embj.201797079.

  • Deniaud, A., Karuppasamy, M., Bock, T., Masiulis, S., Huard, K., Garzoni, F., Kerschgens, K., Beck, M., Neu-Yilik, G. & Schaffitzel, C.* (2015) Structure of the SMG-1/SMG-8/SMG-9 Kinase Complex with the Nonsense-Mediated mRNA Decay Factor Upf1 by Cryo-EM. Nucl. Acids Res. 43, 7600-7611.

  • Von Loeffelholz, O., Jiang, Q., Airosa, A., Karuppasamy, M., Huard, K., Berger, I., Shan, SO & Schaffitzel, C.* (2015) The ribosome-SRP-FtsY co-translational targeting complex in the closed state. Proc. Natl. Acad. Sci. U.S.A. 112, 3943-3948.

  • Gaubitz, C., Maia De Oliveira, T., Prouteau, M., Leitner, A., Karuppasamy, M., Constantinidou, G., Rispal, D., Eltschinger, S., Robinson, G., Thore, S., Aebersold, R., Schaffitzel, C.* & Loewith, R.* (2015) Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2, Mol. Cell 58, 977-988.

  • von Loeffelholz, O., Knoops, K., Ariosa, A., Zhang, X., Karuppasamy, M., Huard, K., Schoehn, G., Berger, I., Shan, S.O.* & Schaffitzel, C.* (2013) Structural Basis of Signal Sequence Surveillance and Selection by the SRP-SR Complex. Nat. Struct. Mol. Biol. 20, 604-610.

  • Estrozi, L.F., Boehringer, D., Shan, S.O., Ban, N. & Schaffitzel, C.* (2011) Structure of the E. coli Co-translational Targeting Complex in the Stable Early Conformation. Nat. Struct. Mol. Biol. 18, 88-90.

  • Schaffitzel, C., Oswald, M., Berger, I., Ishikawa, T., Abrahams, J.P., Koerten, H.K., Koning, R.I. & Ban, N. (2006) Structure of the E. coli signal recognition particle bound to a translating ribosome. Nature 444, 503-506.

Complete list of publications

Selected projects

  • Structure and Mechanism of Key Nonsense-Mediated mRNA Decay Factor Complexes

  • ADDovenom: Novel Snakebite Therapy Platform of Unparalleled Efficacy, Safety and Affordability’

Membership in scientific bodies/juries

  • Appointed Committee member of the Royal Society & Wellcome Trust Sir Henry Dale Fellowship Interview Committee (SHDFIC), since 2021

  • Member of the iNEXT Horizon 2020 – User Panel, since 2020

  • Jury Member of the ‘Friedmund Neumann Prize 2020’ Schering Stiftung, Berlin, 2020 & 2021

  • Appointed Member of the Advisory Network of the Schering Stiftung, Berlin, since 2019

  • Member of Diamond Peer Review Panel 12 covering eBIC and B24, Harwell, UK, since 2019

  • Appointed Academic Lead of the GW4 Facility for High-Resolution Electron Cryo-Microscopy, Bristol, since 2018

  • Jury Member of the ‘Caroline von Humboldt-Preis 2015’ and ‘Caroline von Humboldt-Professur’, Humboldt University, Berlin, Germany, 2015

  • Appointed Member of the Biology Committee, Institut Laue-Langevin (ILL), Grenoble, appointed 2010 – 2013

  • Treasurer, Chemistry Society of Zurich (CGZ), Switzerland, 2007

  • Representative for mid-level faculty, Council of the Institute of Molecular Biology and Biophysics, Swiss Federal Institute of Technology Zurich (re-elected 2005), 2004

Additional qualifications

  • Didactics and management training: Leading Competence Training for Scientists, EMBL Grenoble, Switzerland, 2009

  • Swiss Federal Institute of Technology (ETH) Zurich Faculty Development Program in Didactics, Master level, 2006 – 2007

  • Conflict management seminar for scientists, organised by the Young Academy, Berlin, Germany, 2006

  • Young Leaders in Science Programme, organised by the Schering Foundation, Berlin, 2006

  • Management competence training for scientists, organised by the Young Academy, Berlin, 2005

  • ETH course in didactics (I + II), pedagogy, didactics for chemistry (I + II) (courses towards advanced teaching certification), 2002 – 2003


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