Prof. Dr. Christiane Berger-Schaffitzel

• Since 2020 Coordinator of ADDovenom consortium, funded by EC Horizon2020

• Since 2018 Wellcome Trust Investigator

• Since 2014 Professor of Biochemistry, University of Bristol (UK)

• 2007 – 2016
  Team leader for cryo-electron microscopy at the European Molecular Biology Laboratory (EMBL)
  
  

• 2006 – 2007
  Research associate and lecturer at the Institute of Molecular Biology and Biophysics (IMB), Swiss Federal Institute of Technology Zurich
  
  

• 2001 – 2005
  Postdoc, IMB, Swiss Federal Institute of Technology Zurich
  
  

• 1997 – 2001
  PhD studies, Institute of Biochemistry, University of Zurich
  
  

• 1992 – 1997
  Studied biochemistry at Leibniz University Hanover (LUH), Medical University of Hanover (MHH), Germany, and Swiss Federal Institute of Technology Zurich, Switzerland
  
  

• Toelzer, C., Gupta, K., Yadav, S.K.N., Borucu, U., Davidson, A.D., Williamson, M.K., Shoemark, D.K., Garzoni, F., Staufer, O., Milligan, R., Capin, J., Mulholland, A.J., Spatz, J., Fitzgerald, D., Berger, I. & Schaffitzel, C.* (2020) Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein. Science 370, 725-730. DOI: 10.1126/science.abd3255.

• Powers, K.T., Stevenson-Jones, F.. Yadav, S.K.N., Amthor, B., Bufton, J., Borucu, U., Shen, D. , Becker, J., Larysh D., Hentze, M., Kulozik, A., Neu-Yilik, G. & Schaffitzel, C.* (2021) Blasticidin S inhibits peptide bond formation and release in mammalia and modulates translation dynamics at premature termination codons. Nucl. Acids Res. 49, 7665-7679. doi: 10.1093/nar/gkab532.

• Eliseev, B., Yeramala, L., Leitner, A., Karuppasamy, M., Raimondeau, E., Huard, K., Alkalaeva, E., Aebersold, R. & Schaffitzel, C.* (2018) Structure of human cap-dependent 48S translation pre-initiation complex. Nucl. Acids Res. 46, 2678–2689. https://doi.org/10.1093/nar/gky054.

• Karuppasami, M., Kusminder, B., Oliveira, T.M., Gaubitz, C., Prouteau, M., Loewith, R.* & Schaffitzel, C.* (2017) Structure of the Saccharomyces cerevisiae Target of Rapamycin Complex 2. Nat. Commun. 8, 1729. DOI: 10.1038/s41467-017-01862-0.

• Neu-Yilik, G., Raimondeau, E., Eliseev, B., Yeramala, L., Amthor, B., Deniaud, A., Huard, K., Kerschgens, K., Hentze, M.W.*, Schaffitzel, C.* & Kulozik, A. E.* (2017) Dual function of UPF3B in early and late translation termination. EMBO J. 36, 2968-2986. DOI:10.15252/embj.201797079.

• Deniaud, A., Karuppasamy, M., Bock, T., Masiulis, S., Huard, K., Garzoni, F., Kerschgens, K., Beck, M., Neu-Yilik, G. & Schaffitzel, C.* (2015) Structure of the SMG-1/SMG-8/SMG-9 Kinase Complex with the Nonsense-Mediated mRNA Decay Factor Upf1 by Cryo-EM. Nucl. Acids Res. 43, 7600-7611.

• Von Loeffelholz, O., Jiang, Q., Airosa, A., Karuppasamy, M., Huard, K., Berger, I., Shan, SO & Schaffitzel, C.* (2015) The ribosome-SRP-FtsY co-translational targeting complex in the closed state. Proc. Natl. Acad. Sci. U.S.A. 112, 3943-3948.

• Gaubitz, C., Maia De Oliveira, T., Prouteau, M., Leitner, A., Karuppasamy, M., Constantinidou, G., Rispal, D., Eltschinger, S., Robinson, G., Thore, S., Aebersold, R., Schaffitzel, C.* & Loewith, R.* (2015) Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2, Mol. Cell 58, 977-988.

• von Loeffelholz, O., Knoops, K., Ariosa, A., Zhang, X., Karuppasamy, M., Huard, K., Schoehn, G., Berger, I., Shan, S.O.* & Schaffitzel, C.* (2013) Structural Basis of Signal Sequence Surveillance and Selection by the SRP-SR Complex. Nat. Struct. Mol. Biol. 20, 604-610.

• Estrozi, L.F., Boehringer, D., Shan, S.O., Ban, N. & Schaffitzel, C.* (2011) Structure of the E. coli Co-translational Targeting Complex in the Stable Early Conformation. Nat. Struct. Mol. Biol. 18, 88-90.

• Schaffitzel, C., Oswald, M., Berger, I., Ishikawa, T., Abrahams, J.P., Koerten, H.K., Koning, R.I. & Ban, N. (2006) Structure of the E. coli signal recognition particle bound to a translating ribosome. Nature 444, 503-506.

• Structure and Mechanism of Key Nonsense-Mediated mRNA Decay Factor Complexes

• ADDovenom: Novel Snakebite Therapy Platform of Unparalleled Efficacy, Safety and Affordability’

• Appointed Committee member of the Royal Society & Wellcome Trust Sir Henry Dale Fellowship Interview Committee (SHDFIC), since 2021

• Member of the iNEXT Horizon 2020 – User Panel, since 2020

• Jury Member of the ‘Friedmund Neumann Prize 2020’ Schering Stiftung, Berlin, 2020 & 2021

• Appointed Member of the Advisory Network of the Schering Stiftung, Berlin, since 2019

• Member of Diamond Peer Review Panel 12 covering eBIC and B24, Harwell, UK, since 2019

• Appointed Academic Lead of the GW4 Facility for High-Resolution Electron Cryo-Microscopy, Bristol, since 2018

• Jury Member of the ‘Caroline von Humboldt-Preis 2015’ and ‘Caroline von Humboldt-Professur’, Humboldt University, Berlin, Germany, 2015

• Appointed Member of the Biology Committee, Institut Laue-Langevin (ILL), Grenoble, appointed 2010 – 2013

• Treasurer, Chemistry Society of Zurich (CGZ), Switzerland, 2007

• Representative for mid-level faculty, Council of the Institute of Molecular Biology and Biophysics, Swiss Federal Institute of Technology Zurich (re-elected 2005), 2004

• Professor Christiane Berger-Schaffitzel named the coolest person in Bristol 2020, article on bris.ac.uk

• The pride of Bristol – Dr. Christiane Berger-Schaffitzel, article on thebristolmag.co.uk

• The Bristol Cool List 2020, article on bristolpost.co.uk

• International Women's Day: the 87 most influential women in Bristol right now, article on bristolpost.co.uk

• New type of antivenom to reduce 100,000 fatalities each year from venomous snake bites, article on newswise.com

• Bristol researchers bite back at snakebites – The hidden health crisis", article on epigram.org.uk

• Didactics and management training: Leading Competence Training for Scientists, EMBL Grenoble, Switzerland, 2009

• Swiss Federal Institute of Technology (ETH) Zurich Faculty Development Program in Didactics, Master level, 2006 – 2007

• Conflict management seminar for scientists, organised by the Young Academy, Berlin, Germany, 2006

• Young Leaders in Science Programme, organised by the Schering Foundation, Berlin, 2006

• Management competence training for scientists, organised by the Young Academy, Berlin, 2005

• ETH course in didactics (I + II), pedagogy, didactics for chemistry (I + II) (courses towards advanced teaching certification), 2002 – 2003

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