Short CV/Education and training

  • After a Masters Degree in Theoretical Physics from the University of Turin, I completed a PhD in Physics and Mathematical Modelling at the Institute of Cancer Research, University of London. I then undertook postdoctoral research at the Gray Cancer Institute, London, before joining the Medical Sciences Division, University of Oxford, first as a postdoctoral research fellow, then as Principal Investigator and Head of the Computational Biology and Integrative Genomics Lab.

  • In addition to my research work, I teach post-graduate courses, including the new MSc in Precision Cancer Medicine, where I lead the omics module, and the MSc in Radiation Biology, where I teach statistics and omics applications. I also teach at national and international Masters Courses and Advanced Schools, including yearly MSc courses at the University of Tsukuba, Japan, and the Advanced Courses at the Wellcome Genome Campus, University of Cambridge, UK.

Selected publications

  • Skwarski M, McGowan DR, Belcher E, Di Chiara F, Stavroulias D, McCole MG, Derham J, Chu KY, Teoh E, Chauhan J, O'Reilly D, Harris BHL, Macklin PS, Bull JA, Green M, Rodriguez-Berriguete G, Prevo R, Folkes LK, Campo L, Ferencz P, Croal P, Flight H, Qi C, Holmes J, O'Connor JPB, Gleeson F, McKenna WG, Harris AL, Bulte D, Buffa FM, Macpherson RE, Higgins GS. Mitochondrial Inhibitor Atovaquone Increases Tumor Oxygenation and Inhibits Hypoxic Gene Expression in Patients with Non-Small Cell Lung Cancer. Clin Cancer Res:clincanres.4128.2020 (2021)

  • Di Giovannantonio M, Harris BH, Zhang P, Kitchen-Smith I, Xiong L, Sahgal N, Stracquadanio G, Wallace M, Blagden S, Lord S, Harris D, Harris AHL, Buffa FM (corresponding), Bond GL. Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits. J Med Genet.: jmedgenet-2019-106799. Online ahead of print (2020)

  • Dhawan A, Barberis A, Cheng WC, Domingo E, West C, Maughan T, Scott JG, Harris AL, Buffa FM (corresponding). Guidelines for using sigQC for systematic evaluation of gene signatures. Nature Protocols 14(5):1377-1400. doi: 10.1038/s41596-019-0136-8 (2019)

  • Burdova K, Yang H, Faedda R, Hume S, Chauhan J, Ebner D, Kessler BM, Vendrell I, Drewry DH, Wells CI, Hatch SB, Dianov GL, Buffa FM, D'Angiolella V. E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition. EMBO J. 38(20):e101443. doi:10.15252/embj.2018101443 (2019)

  • Voukantsis D, Kahn K, Hadley M, Wilson R, Buffa FM (corresponding). Modeling genotypes in their microenvironment to predict single- and multi-cellular behaviour. Gigascience. 8(3). pii: giz010. doi: 10.1093/gigascience/giz010. PMID: 30715320 (2019)

  • Lord SR, Cheng WC, Liu D, Gaude E, Haider S, Metcalf T, Patel N, Teoh EJ, Gleeson F, Bradley K, Wigfield S, Zois C, McGowan DR, Ah-See M, Thompson A, Sharma A, Bidaut L, Pollak M, Roy P, Karpe F, James T, English R, Adams R, Campo L, Ayers L, Snell C, Roxanis I, Frezza C, Fenwick J, Buffa FM (joint last), Harris AL. Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer. Cell Metabolism 28(5)679-688 (2018)

  • Dhawan A, Scott J, Harris AL, Buffa FM (corresponding). Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA mediated downregulation of tumour suppressors. Nature Communications, 9 (1), 5228 (2018)

  • Haider S, McIntyre A, van Stiphout RG, Winchester LM, Wigfield S, Harris AL, Buffa FM (corresponding). Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia. Genome Biology 17(1)140 (2016)

  • Mehta S, Hughes NP, Li S, Jubb A, Adams R, Lord S, Koumakis L, van Stiphout R, Padhani A, Makris A, Buffa FM (joint last and corresponding), Harris AL. Radiogenomics Monitoring in Breast Cancer Identifies Metabolism and Immune Checkpoints as Early Actionable Mechanisms of Resistance to Anti-angiogenic Treatment. EBioMedicine. (2016) 10109-16.

  • Masiero M, Costa Simões F, Dong Han H, Snell C, Peterkin T, Bridges E, Mangala L, Yen-Yao Wu S, Pradeep S, Li D, Han C, Dalton H, Lopez-Berestein G, Tuynman J, Mortensen N, Li J, Patient R, Sood AK, Banham A, Harris A, Buffa FM (corresponding). A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis. Cancer Cell 24229-41 (2013)

    This paper was featured in Highlights, American Association of Cancer Research, Cancer Res 73; 5299 (2013)



Complete list of publications

Membership in scientific bodies/juries

  • COVID NIHR prioritization panel

  • Horizon2020

  • European Research Council

  • Medical Research Council

  • UK Research Institute

  • Cancer Research UK

  • Member of governative evaluation panels, including service as member of the Biological Science Panel and Interdisciplinary Advisor for the REF-2021

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