PhD Mar Albà
Biological and related sciences, Evolution, genomics, bioinformatics
Biological and related sciences, Health
Immunology
Immune regulation
mucosal immunity
autoimmunity
alveolar epithelium
host-pathogen interaction
infection and autoimmunity
regulatory T cells
immune modulation in the context of infections
Short-listed (no. 2) for a W2 professor position in host septomics, Faculty of Medicine, Friedrich Schiller University, Jena, Germany / German Federal Ministry of Education and Research (BMBF), 2010
Short-listed (no. 1) for a W2 professor position in innate immunity, Faculty of Medicine, University of Lübeck, Germany; declined offer, 2009
Advisor of the Year 2008, Helmholtz Centre for Infection Research, Germany
Young Investigator Award from the Society of Mucosal Immunology, Boston, MA, USA, 2005
English, German
Bruder, D. et al.: Neuropilin-1 – a surface marker of regulatory T-cells. In: Eur. J. Immunol. 34, 2004. S. 623-630.
Bruder, D. et al.: CD4 T lymphocyte-mediated lung disease: steady state between pathological and tolerogenic immune reactions. In: Am. J. Respir. Crit. Care Med. 170, 2004. S. 1145-1152.
Westendorf, A.M. et al.: CD4+ T cell mediated intestinal immunity: chronic inflammation versus immune regulation. In: Gut 54, 2005. S. 60-69.
Bruder, D. et al.: On the edge of autoimmunity: T cell stimulation by steady state dendritic cells prevents autoimmune diabetes. In: Diabetes 54, 2005. S. 3395-3401.
Bruder, D. et al.: Multiple synergizing factors contribute to the strength of the CD8+ T cell response against listeriolysin O. In: International Immunology 18(1), 2006. S. 89-100.
Westendorf, A.M. et al.: Autoimmune-mediated intestinal inflammation – impact and regulation of antigen specific CD8+ T cells. In: Gastroenterology 131(2), 2006. S. 510-524.
Gereke, M. et al.: Phenotypic alterations in type II alveolar epithelial cells in CD4+ T cell mediated lung inflammation. In: Respiratory Research 8, 2007. S. 47.
Hansen, W. et al.: Chronic antigen stimulation in vivo induces a distinct population of antigen-specific Foxp3lowCD25-regulatory T cells. In: Journal of Immunology 179, 2007. S. 8059-8068.
Gereke, M. et al.: Type II alveolar epithelial cells present antigen to CD4+ T cells and induce Foxp3+ regulatory T cells. In: Am. J. Resp. Crit. Care Med. 179(5), 2009. S. 344-355.
Stegemann, S. et al.: Increased susceptibility for superinfection with Streptococcus pneumoniae during influenza virus infection is not caused by TLR7-mediated lymphopenia. In: PLoS ONE 4(3), 2009. e4840.
Bar-On, L. et al.: CX3CR1pos CD8?pos dendritic cells are a steady state population related to plasmacytoid dendritic cells. In: PNAS 2010 (Epub ahead of print).
Project leader in Collaborative Research Centres SFB 587 and 738 (also in SFB 621 until 06/2009); project leader in the Helmholtz Alliance on Immunotherapy of Cancer
Member of the German Society for Immunology
Member of the German Association of University Professors and Lecturers
Member at the Infection Biology Centre (ZIB), Hannover Medical School (MHH), Germany
Member of the MD/PhD programme Molecular Medicine, MHH
Member of independent junior research group (IRTG 1273), MHH
Member of the Helmholtz Centre for Infection Research (HZI) Graduate School
Ad hoc referee for various international journals
Participated in the Helmholtz Management Academy, the optimal preparation for future management positions, 2009 – 2011
Trained as an internal mediator
In addition to carrying out first-class research, I consider the following to be particularly important: supporting the young researchers under me, teaching well, and having an interpersonal relationship based on trust with the members of my research group.
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Biological and related sciences, Evolution, genomics, bioinformatics
Biological and related sciences, cell biology, molecular biology, biomedicine
Biological and related sciences, Evolutionary biology, Evolutionary genetics
Biological and related sciences, Evolutionary biology, Animal behaviour, Gender studies, Science studies
Our immune system fights pathogens, but it sometimes overshoots the mark and damages body tissue. Researchers from the Helmholtz Centre for Infection Research HZI report that activation of a molecule called ICOS, on the surface of immune cells, limits the extent of lung damage during the infection.
When infected with influenza, the body becomes an easy target for bacteria. Now, a team of immunologists at the Helmholtz Centre for Infection Research HZI and partners has discovered how the flu virus alters the host's immune system and compromises its capacity to effectively fight off bacterial infections.
In healthy lungs, several mechanisms prevent the body's immune system to attack lung tissue. But in case of chronic obstructive pulmonary disease (COPD), these mechanisms cease to function properly. The research group of Prof. Dunja Bruder at the Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany, has explored and described these processes in great detail.