Prof. Lital Alfonta
Biological and related sciences, Physical sciences, Bioelectrochemistry, Synthetic Biology, Chemical Biology
Biological and related sciences
Molecular Microbiology, Microbial Proteomics and Redox biology
1) Bacterial redox-sensing regulators and the role of bacterial redox buffer
2) Proteomics and Thiol-Redox proteomics in Gram-positive bacteria
3) Bacterial secretome analyses
ERC Consolidator Grant Award, 2013
Awardee of the Käthe-Kluth-Stipendium of the University of Greifswald, 2009 – 2012
Prize for best PhD graduation at the University of Greifswald, 1998
English, German
Loi VV, Rossius M, Antelmann H. Redox regulation by reversible protein S-thiolation in bacteria. Front Microbiol. 6:187. doi: 10.3389/fmicb.2015.00187.
(2015)
Hillion M, Antelmann H. Thiol-based redox switches in prokaryotes. Biol Chem. 396: 415-44. doi: 10.1515/hsz-2015-0102 (2015)
Gaballa A, Chi BK, Roberts AA, Becher D, Hamilton CJ, Antelmann H, Helmann JD. Redox regulation in Bacillus subtilis: The bacilliredoxins BrxA(YphP) and BrxB(YqiW) function in de-bacillithiolation of S-bacillithiolated OhrR and MetE. Antioxid Redox Signal. 21: 357-67. doi: 10.1089/ars.2013.5327. (2014)
Chi, B. K., Busche. T., Van Laer, K., Bäsell, K., Becher, D., Clermont, L., Seibold, G., Persicke, M., Kalinowski, J., Messens, J. and Antelmann, H.* Protein S-mycothiolation functions as redox-switch and thiol protection mechanism in Corynebacterium glutamicum under hypochlorite stress. Antioxidants & Redox Signaling 20:589-605, doi:10.1089/ars.2013.5423. (2014)
Chi, B.K., Roberts, A., Huyen, T.T.T., Gronau, K., Becher, D., Albrecht, D., Hamilton, C. and Antelmann, H.* S-bacillithiolation protects conserved and essential proteins against hypochlorite stress in Firmicutes bacteria. Antioxidants & Redox Signaling 18: 1273-1295. (2013)
Palm, G. J., Chi, B. K., Waack, P.; Gronau, K., Becher, D., Albrecht, D., Hinrichs, W., Read, R.J., Antelmann, H.* Structural insights into the redox-switch mechanism of the MarR/DUF24-type regulator HypR. Nucleic Acids Research; 40: 4178-4192. (2012)
Chi, B.K., Gronau, K., Mäder, U., Hessling, B., Becher, D., Antelmann, H.* S-bacillithiolation protects against hypochlorite stress in Bacillus subtilis as revealed by transcriptomics and redox proteomics. Mol. Cell. Proteomics, 10: M111.009506. (2011)
Antelmann, H.*, and Helmann, J.D*. Thiol-based redox switches and gene regulation. Forum Review Article on “Redox switches”. Antioxidants & Redox Signaling, 14,1049-1063. (2011)
Gaballa, A., Newton, J., Antelmann, H., Parsonage, D., Upton, H., Rawat, M., Claiborne, A., Fahey, R., and Helmann, J.D.* Biosynthesis and functions of Bacillithiol: a major low molecular weight thiol in Bacilli, Proc. Natl. Acad. Sci. 107: 6482-6486. (2010)
Antelmann, H., Tjalsma, H., Voigt, B., Ohlmeier, S., Bron, S., van Dijl,*J.M., and Hecker, M. A proteomic view on genome-based signal peptide predictions. Genome Research 11: 14984-14502. (2001)
Tjalsma, H., Antelmann, H., Jongbloed, J.D., Braun, P.G., Darmon, E., Dorenbos, R., Dubois, J.Y., Westers, H., Zanen, G., Quax, W.J., Kuipers, O.P., Bron, S., Hecker, M., J. M. van Dijl*. Proteomics of Protein Secretion by Bacillus subtilis: Separating the "Secrets" of the Secretome. Microbiol. Mol. Biol. Rev. 68: 207-233. (2004)
ERC Consolidator Grant GA No. 615585 MYCOTHIOLOME
DFG-SPP1710-project about Thiol-based redox switches and redox sensors in Staphylococcus aureus
DFG-GRK1947-project about redox proteomics in Mycobacterium smegmatis
Associate Editor of "BMC Microbiology"
Advisory Editorial Board member of "Molecular Microbiology"
Editorial Board member of "Scientific Reports"
Review Editor of “Frontiers in Microbiol physiology and Metabolism”
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Biological and related sciences, Physical sciences, Bioelectrochemistry, Synthetic Biology, Chemical Biology
Biological and related sciences, Evolution, genomics, bioinformatics
Biological and related sciences, Evolutionary biology, Animal behaviour, Gender studies, Science studies
Biological and related sciences, Molecular biology, molecular microbiology, biochemistry, membrane protein biochemistry