Short CV/Education and training

  • 1995
    Final Medical Board Examination (MD), Medicine, University of Munich

  • 1996
    Dr. med. (Medicine, Translational Research) University of Munich, with summa cum laude

  • 1997 – 1999
    Postdoctoral Fellow (Molecular Biology, Metastasis), MD Anderson Cancer Center, Houston/USA

  • 1999
    PhD, Molecular Biology, Graduate School of Biomedical Sciences (GSBS), MD Anderson Cancer Center, Houston/USA

  • 1999 – 2001
    Assistant Professor, Section Molecular Biology, Dept. Surgery, Clinical Surgeon, Surgical Oncology, University of Munich

  • 2001
    Priv.Doz. (Associate Professor), Experimental Surgery/Molecular Biology, University of Munich

  • 2003
    Diploma in Medical Economics, Chur, Switzerland

  • 2004
    Surgical Board Exam, Munich/Germany

  • Since 2004
    Full Professor and Head, Dept. of Experimental Surgery, Med. Faculty Mannheim, Univ. of Heidelberg: Adjunct Professor and Head, Molecular Oncology of Solid Tumors Unit, DKFZ Heidelberg

Selected publications

  • Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S, Allgayer,H: MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2008, 27, 2128-2136. (Most cited Original Article Oncogene 2009)

  • Mudduluru G, Ceppi P, Kumarswamy R, Scagliotti GV, Papotti M, Allgayer H: Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancer. Oncogene 2011, 30, 2888-2899

  • Nikolova DA, Asangani IA, NelsonLD, Hughes DP, Siwak DR, Mills GB, Harms A, Buchholz E, Pilz LR, Manegold C, Allgayer H: Cetuximab attenuates metastasis and u-PAR expression in non-small cell lung cancer: u-PAR and E-cadherin are novel biomarkers of cetuximab sensitivity. Cancer Res 2009, 69, 2461-2470

  • Mudduluru G, Medved F, Grobholz R, Joste C, Gruber A, Leupold JH, Post S, Jansen A, Colburn NH, Allgayer H: Loss of Pdcd4 expression marks adenoma-carcinoma transition, correlates inversely with pAkt, and is a new and independent prognostic factor in resected colorectal cancer. Cancer 2007, 110:8, 1697-1707

  • Heiss MM, Simon EH, Beyer BCM, Grützner KU, Tarabichi A, Babic R, Schildberg FW, Allgayer H: Minimal residual disease in gastric cancer: First evidence of an independent prognostic relevance of urokinase receptor gene expression by disseminated tumor cells in a large series of patients. The Journal of Clinical Oncology 2002, 20(8):2005-2016

  • Leupold JH, Yang HS, Colburn NH, Asangani I, Post S, Allgayer H: Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors. Oncogene 2007, 26, 4550-62

  • Maurer GD, Leupold JH, Schewe DM, Biller T, Kates RE, Hornung H-M, Lau-Werner U, Post S, Allgayer H: First analysis of specific transcriptional regulators as predictors of independent prognostic relevance in resected colorectal cancer. Clinical Cancer Research 2007, 13(4): 1123-1132

  • Ceppi P, Mudduluru G, Regalla K, Rap I, Scagliotti GV, Papotti M, Allgayer H: Loss of miR-200c expression induces an aggressive, invasive, and chemoresistant phenotype in non-small-cell lung cancer. Mol Cancer Res Sept 2010, 8(9): 1207-16 Highlight of the Issue

  • Schewe DM, Leupold JH, Boyd DD, Lengyel ER, Wang H, Gruetzner KU, Schildberg FW, Jauch KW, Allgayer H: Tumor-specific transcription factor binding to an activator protein-2/Sp1 element of the urokinase-type plasminogen activator receptor promoter in a first large series of resected gastrointestinal cancers. Clin Cancer Res 2003, Jun;9(6):2267-76.

  • Regalla K, Mudduluru G, Ceppi P, Muppala S, Kozlowski M, Niklinski J, Papotti M, Allgayer H: MicroRNA-30a inhibits epithelial-to-mesenchymal transition by targeting Snai1 and is downregulated in non-small cell lung cancer. Int J Cancer 2011, Jun 1, doi: 10, 1002 [Epub ahead of print]

Complete list of publications

Selected projects

Ongoing grant-supported projects:

  • Alfried Krupp von Bohlen und Halbach-Foundation, Essen: Molecular tumor staging translating molecular knowledge on metastasis into patient benefit

  • Merck, Darmstadt: Translational studies at resected patient tissues on Cetuximab response and resistance

  • Dr. Hella-Bühler-Foundation, Heidelberg: Molecular regulators of metastasis as individual clinical risk factors

  • Hector-Foundation, Weinheim: Role of CXRC4 in colorectal cancer metastasis and therapy

  • Grant Support of the University of Heidelberg Foundation Role of specific microRNAs in EMT

  • German-Israeli Project Cooperation (DKFZ-MOST): MicroRNA control of tissue invasion in inflammatory intestinal cancer

  • Deutsche Krebshilfe, Bonn: Role of specific microRNAs in the regulation of carcinoma metastasis

  • Complete Genomics, Inc., Mountain View, CA/USA: Pilot studies on genome sequencing of resected metastases

  • Wilhelm Sander Foundation The functional interplay between CD24, Src, miR-21, Pdcd4 and u-PAR, and its impact on invasion and metastasis

Membership in scientific bodies/juries

Professional Memberships:

  • American Association of Cancer Research (AACR)

  • Bavarian College of Surgeons

  • German College of Surgeons

  • Molecular Biology Chapter of the German College of Surgeons (CAMO)

  • Professional Board of German Surgeons (BDC)

  • European Association of Cancer Research (EACR)

  • American Society of Clinical Oncology (ASCO)

  • EACR Council Member as Representative of Germany, Member of the Communications Committee

  • Stem Cell Research Society

  • Metastasis Research Society

Activities in the scientific community

  • Associate Editor, International Journal of Cancer

  • Editorial Board: Advances in Medical Sciences, Journal of Cellular and Molecular Medicine, Frontiers in Molecular and Cellular Oncology, The Open Surgical Oncology Journal

  • Reviewer: Cancer Research, Clinical Cancer Research, Oncogene, Methods in Enzymology. European Journal of Surgical Research, Oncology, Molecular Cancer, International Journal of Colorectal Disease, Gastroenterology, Cancer Letters, British Journal of Cancer, Nucleic Acids Research, FEBS Journal; The Open Surgical Oncology Journal, Molecular and Cellular Biology (MCB), APMIS, Journal of Cellular and Molecular Medicine, Frontiers in Molecular and Cellular Oncology, World Journal of Clinical Oncology, PLOs ONE. Reviewer of Wilhelm Sander Foundation, Deutsche Krebshilfe (German Cancer Foundation), the European Community, the German Israeli Foundation for Scientific Research and Development, the Deutsche Forschungsgemeinschaft (DFG), the Alexander-von-Humboldt Foundation, the Swedish Academy of Sciences, Stockholm/Sweden, the Association for International Cancer Research (AICR), the Scientific Selection Committee for the King Faisal International Prize, Riyadh/Saudi Arabia

  • Founder of the international meeting series “Molecular Staging of Cancer”

  • Elected Chair of the Fellows of the Ingrid-zu-Solms Foundation for excellent Women in Research, Medicine and Culture, Frankfurt/Main

Additional qualifications

  • Diploma in Medical Economics, Chur, Switzerland, 2003


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