Short CV/Education and training

  • 1962 – 1967
    Studied biology at the Humboldt University of Berlin, Germany

  • 1970
    Doctor of Natural Science (Dr. rer. nat.) at the Humboldt University of Berlin

  • 1971 – 1972
    Research associate at the German Academy of Sciences in Berlin-Buch

  • 1972 – 1980
    Research associate at the Max Planck Institute for Biochemistry in Munich

  • 1977
    Habilitation (postdoctoral qualification) in zoology in the Department of Biology at LMU Munich

  • 1980 – 1984
    Leader of a research group at the Institute for Biochemistry at the University of Würzburg

  • 1985 – 1989
    Professor of microbiology at the Institute for Virology and Immunology in Würzburg

  • Since 1989
    German Cancer Research Centre (DKFZ)

Selected publications

  • Santoro, R., Li, J., Grummt, I.: The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. In: Nature Genetics 32, 2002. S. 393-396.

  • Mayer, C. et al.: mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability. In: Genes Dev. 18, 2004. S. 423-434.

  • Mayer, C., Bierhoff, H., Grummt, I.: The nucleolus as a stress sensor: JNK inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis. In: Genes Dev. 19, 2005. S. 933-941.

  • Yuan, X. et al.: Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest and p53-mediated apoptosis. In: Mol. Cell 19, 2005. S. 77-89.

  • Mayer, C. et al.: Intergenic transcripts regulate the epigenetic state of rRNA genes. In: Mol. Cell 22, 2006. S. 351-361.

  • Yuan, X. et al.: Activation of RNA polymerase I transcription by Cockayne Syndrome group B (CSB) protein and histone methyltransferase G9a. In: Mol. Cell 27, 2007. S. 585-595.

  • Ye, J. et al.: Nuclear myosin I and polymeric actin act as a molecular motor that drives RNA polymerase I transcription. In: Genes Dev. 22, 2008. S. 322-330.

  • Schmitz, K.M. et al.: TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of active genes leading to DNA demethylation. In: Mol. Cell 33, 2009. S. 344-353.

  • Zhou, Y. et al.: Acetylation by hMOF regulates NoRC-dependent heterochromatin formation, nucleosome positioning and transcriptional silencing. In: Nature Cell Biol. 11, 2009. S. 1010-1016.

  • Feng, W. et al.: The Jumonji-C domain containing histone demethylase PHF8 activates transcription of rRNA genes. In: Nature Struct. Mol. Biol. 17, 2010. S. 445-450.

Membership in scientific bodies/juries

  • Elected member of the National Academy of Sciences Leopoldina, since 2008

  • Member of the Advisory Committee of the European Research Council (ERC), since 2007

  • Member of the Scientific Advisory Council of EuTRACC (European Transcriptome, Regulome & Cellular Commitment Consortium), since 2007

  • Member of the Advisory Council of the Institute of Molecular Biotechnology (IMB) in Jena, since 2004

  • Member of the European Molecular Biology Organisation (EMBO) Council, 2002 – 2007

  • Member of the Academia Europea, since 1998

  • Member of the Advisory Council of the National Research Centre for Biotechnology (GBF) in Braunschweig, 1996 – 2004

  • Member of the German American Academic Council (GAAC), 1994 – 1997

  • Elected member of the German Cancer Research Centre (DKFZ) board of trustees, 1992 – 2005

  • EMBO member, since 1985


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