Short CV/Education and training

  • 1985 – 1987
    Doctoral studies at Saarland University, Saarbrücken, and Lund University, Sweden

  • 1988 – 1990
    Post-doc at the Research Institute of Molecular Pathology (IMP) in Vienna, Austria

  • 1991 – 1995
    Post-doc at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany

  • Since 1996
    Independent leader of the research group Mammalian Cell Cycle Control Mechanisms at the German Cancer Research Center (DKFZ) in Heidelberg

Selected publications

  • Hoffmann, I. and Birnstiel, M.L. (1990). The cell-cycle dependent regulation of histone precursor mRNA processing involves heat-labile factor modulation of U7 snRNA accessibility, Nature 346, 665-668

  • Hoffmann, I., Clarke, P, Marcote, M.J., Karsenti, E. and Draetta, G. (1993) Activation of Cdc25 by phosphorylation at mitosis and its involvement in the self-amplification of MPF. EMBO J. 12, 53-63.

  • Hoffmann, I., Draetta, G. and Karsenti, E. (1994) Activation of the phosphatase activity of human Cdc25A by a Cdk2-cyclin E dependent phosphorylation at the G1/S transition EMBO J. 13, 4302-4310.

  • Blomberg, I and Hoffmann, I. (1999) Ectopic expression of Cdc25A accelerates the G1/S transition and leads to activation of cyclin E and cyclin A-dependent kinases. Mol. Cell. Biol. 19, 6183-6194.

  • Warnke S., Kemmler S., Hames RS, Tsai HL, Hoffmann-Rohrer U., Fry AM, and Hoffmann I. (2004) The polo-like kinase-2 is required for centriole duplication in mammalian cells. Curr. Biol. 14, 1200-1207.

  • Cizmecioglu, O., Arnold, M., Bahtz, R., Settele, F., Ehret, L., Haselmann-Weiß, U., Antony, C. and Hoffmann, I. (2010). Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome. J. Cell Biol. 191, 731-739.

  • Puklowski, A., Homsi, Y., Chauhan, S., Keller, D., Grünwald, V., Kubicka, S., Pich, A., Mann, M., Hoffmann, I., Gönczy, P. and Malek, N. (2011) The activity of the SCFFbw5 E3-ubiquitin ligase is regulated by the APC/C and Plk4 to control centrosome duplication. Nat. Cell Biol. 13, 1004-9.

  • Bahtz, R., Seidler, J., Arnold, M., Haselmann-Weiss, U., Antony, C., Lehmann, W and Hoffmann, I., (2012) GCP6 is a substrate of Plk4 and required for centriole duplication, J. Cell Sci., 125, 1-11.

Selected projects


Membership in scientific bodies/juries

  • Business manager of the German Society for Cell Biology (DGZ), 2006 – 2008

  • Member of the advisory board the DGZ, since 2008


You can only see the contact information of the academics in the database if you are a registered user of AcademiaNet.
Please register here


  1. Read what our members say about AcademiaNet.

No more excuses!

  1. Please download the brochure "No more excuses" and read more about female experts in Europe, and about AcademiaNet.

Similar profiles

  1. Dr. Irene Agyepong

    HealthPublic Health

  2. Prof. Dr. Anna Akhmanova

    Biological and related sciences Cell Biology, Molecular Biology, Biochemistry, Microscopy

  3. Prof. Dr. Amparo Acker-Palmer

    Biological and related sciences , HealthCell Biology, Cellular and Molecular Neuroscience, Vascular Biology, Tumour Biology

  4. PhD Mar Albà

    Biological and related sciences Evolution, genomics, bioinformatics