Prof. Dr. Anna Akhmanova
Biological and related sciences, Cell Biology, Molecular Biology, Biochemistry, Microscopy
Biological and related sciences
Developmental biology, molecular biology
regeneration and development of tissue and organs
biology of stem cells
ERC Starting Grant 2016
English, German
Schmidt D, Reuter H, Hüttner K, Ruhe L, Rabert F, Seebeck F, Irimia M, Solana J, and Bartscherer K (2018). The Integrator complex regulates differential snRNA processing and fate of adult stem cells in the highly regenerative planarian Schmidtea mediterranea. PLoS Genet 14:e1007828.
Owlarn S, Klenner F, Schmidt D, Rabert F, Tomasso A, Reuter H, Mulaw MA, Moritz S, Gentile L, Weidinger G, and Bartscherer K (2017). Generic wound signals initiate regeneration in missing-tissue contexts. Nature Commun 8: 2282.
Seebeck F, März M, Reuter H, Vogg MC, Mildner K, Zeuschner D, Rabert F, and Bartscherer K (2017). Integrins are required for tissue organization and restriction of neurogenesis in regenerating planarians. Development, 144, 795-807.
Owlarn S, and Bartscherer K (2016). Go ahead, grow a head! A planarian’s guide to anterior regeneration. Regeneration 3, 139-155.
Reuter H, März M, Vogg MC, Eccles D, Grifol-Boldu L, Owlarn S, Wehner D, Adell T, Weidinger G, and Bartscherer K (2015). -catenin-dependent control of positional information along the AP body axis in planarians involves a Teashirt family member. Cell Rep 10, 253-265.
Hjeij R, Onoufriadis A, Watson CM, Slagle CE, Klena N, Dougherty GW, Kurkowiak M, Loges NT,1 Diggle CP, Morante NFC, Gabriel G, Lemke KL, Li Y, Pennekamp P, Menchen T, Konert F, Marthin JK, Mans DA, Letteboer SJF, Werner C, Burgoyne T, Westermann C, Rutman A, Carr IM, O'Callaghan C, Moya E, Chung EMK, UK10K, Sheridan E, Nielsen KG, Roepman R, Bartscherer K, Burdine RD, Lo CW, Omran H, Mitchison HM (2014). CCDC151 mutations cause Primary Ciliary Dyskinesia by disruption of the Outer Dynein Arm docking complex formation. Am J Hum Genet 95, 257-274.
Almuedo-Castillo M, Crespo X, Seebeck F, Bartscherer K, Salo E, Adell T (2014). JNK controls the onset of mitosis in planarian stem cells and triggers apoptotic cell death required for regeneration and remodeling. PLoS Genetics 10, e1004400.
Vogg MC, Owlarn S, Perez Rico YA, Xie J, Suzuki Y, Gentile L, Wu W, and Bartscherer K (2014). Stem cell-dependent formation of a functional anterior regeneration pole in planarians requires Zic and Forkhead transcription factors. Dev Biol 390, 136-148.
Böser A, Drexler HCA, Reuter H, Schmitz H, Wu G, Schöler HR, Gentile L, and Bartscherer K (2013). SILAC proteomics of planarians identifies Ncoa5 as a conserved component of pluripotent stem cells. Cell Rep 5, 1142-1155.
März, M., Seebeck, F., and Bartscherer, K. (2013). A Pitx transcription factor controls establishment and maintenance of the serotonergic lineage in planarians. Development 140, 4499-4509.
Gross J.C., Chaudhary, V., Bartscherer, K., and Boutros, M. (2012). Active Wnt proteins are secreted on exosomes. Nature Cell Biol 14, 1036-45.
Sandmann, T., Vogg, M.C., Owlarn, S., Boutros, M., and Bartscherer, K. (2011). The head regeneration transcriptome of the planarian Schmidtea mediterranea. Genome Biol 12(8):R76.
Gentile, L., Cebrià, F., and Bartscherer, K. (2011). The planarian flatworm: a model for stem cell biology and nervous system regeneration. Dis Model Mech 4, 12-9.
Buechling, T., Bartscherer, K., Ohkawara, B., Chaudhary, V., Spirohn, K., Niehrs, N., and Boutros, M. (2010). Wnt/Frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor. Curr Biol 20, 1263-1268.
Adell, T., Saló, E., Boutros, M., and Bartscherer, K. (2009). Smed-Evi/Wntless is required for beta-catenin-dependent and -independent processes during planarian regeneration. Development 136, 905-910.
Davidson, G., Shen, J., Huang, Y., Su, Y., Karaulanov, E., Bartscherer, K., Hassler, C., Stannek P., Boutros, M., and Niehrs, C. (2009). Cell Cycle Control of Wnt Receptor Activation. Dev Cell 17, 788-799.
Bartscherer, K., Pelte, N., Ingelfinger, D., and Boutros, M. (2006). Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. Cell 125, 523-533.
three children
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Biological and related sciences, Cell Biology, Molecular Biology, Biochemistry, Microscopy
Biological and related sciences, Health, Cell Biology, Cellular signaling, Cancer biology, Cancer therapy
Biological and related sciences, Evolutionary biology, Evolutionary genetics
Biological and related sciences, Environment, Plant Ecology, Conservation Biology, Landscape Genomics
With the grant's 1,5 million Euros, group leader Dr. Kerstin Bartscherer will set out to investigate how the regeneration of injured or lost body parts can be activated.