Prof. Dr. Krina Zondervan

• Originally from the Netherlands (MSc in Biomedical Sciences, Cum Laude, Leiden 1995), Krina Zondervan obtained her doctorate in Epidemiology at Oxford University (DPhil, 2000), and an MSc in Genetic Epidemiology at Erasmus University, Rotterdam, Netherlands (2001). Throughout her research career, her interest has focussed on the design and application of epidemiological methods in women's health. She is Principal Investigator at the Nuffield Dept of Obstetrics & Gynaecology and the Wellcome Trust Centre for Human Genetics at Oxford University, where she leads a multi-disciplinary research group aimed at understanding the pathogenesis of women's health disorders through genomic, molecular, and environmental epidemiological research methods. She is co-Director of the Endometriosis CaRe Centre in Oxford and Principal Investigator of a number of large-scale collaborative initiatives in the field of endometriosis. She holds numerous international leadership roles and board memberships, and is widely published. For more information see: https://www.obs-gyn.ox.ac.uk/team/krina-zondervan; https://scholar.google.co.uk.

• Sapkota Y, Steinthorsdottir V, Morris AP, Fassbender A, Rahmioglu N, De Vivo I, Buring JE, Zhang F, Edwards TL, Jones S, O D, Peterse D, Rexrode KM, Ridker PM, Schork AJ, MacGregor S, Martin NG, Becker CM, Adachi S, Yoshihara K, Enomoto T, Takahashi A, Kamatani Y, Matsuda K, Kubo M, Thorleifsson G, Geirsson RT, Thorsteinsdottir U, Wallace LM; iPSYCH-SSI-Broad Group, Yang J, Velez Edwards DR, Nyegaard M, [Low SK*, Zondervan KT*, Missmer SA*, D'Hooghe T*, Montgomery GW*, Chasman DI*, Stefansson K*, Tung JY*, Nyholt DR*]. Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism. Nat Commun. 2017;8:15539.

• N, Macgregor S, Drong AW, Hedman AK, Harris HR, Randall JC, Prokopenko I, The International EndoGene Consortium (IEC), The GIANT Consortium, Nyholt DR, Morris AP, Montgomery GW, Missmer SA, Lindgren CM, Zondervan KT. Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci. Hum Mol Genet 2015;24:1185-99.

• Rahmioglu N, Nyholt DR, Morris AP, Missmer SA, Montgomery GW, Zondervan KT. Genetic variants underlying endometriosis risk: insights from eight genome-wide association and replication datasets in 11,000 cases and 32,000 controls. Hum Reprod Update 2014;20:702-16.

• Nyholt DR, Low SK, Anderson CA, Painter JN, Uno S, Morris AP, MacGregor S, Gordon SD, Henders AK, Martin NG, Attia J, Holliday EG, McEvoy M, Scott RJ, Kennedy SH, Treloar SA, Missmer SA, Adachi S, Tanaka K, Nakamura Y, [Zondervan KT, Zembutsu H, Montgomery GW]. Genome-wide association meta-analysis identifies new endometriosis risk loci. Nature Genetics 2012;44:1355-9

• Painter JN, Anderson CA, Nyholt DR, Macgregor S, Lin J, Lee SH, Lambert A, Zhao Z, Roseman F, Guo Q, Gordon SD, Wallace L, Henders AK, Visscher PM, Kraft P, Martin NG, Morris AP, [Treloar SA, Kennedy SH, Missmer SA, Montgomery GW, Zondervan KT]. Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis. Nature Genetics 2011;43:51-4

• Min JL, Nicholson G, Halgrimsdottir I, Almstrup K, Petri A, Barrett A, Travers M, Rayner NW, Mägi R, Pettersson FH, Broxholme J, Neville MJ, Wills QF, Cheeseman J; The GIANT Consortium; The MolPAGE Consortium, Allen M, Holmes CC, Spector TD, Fleckner J, McCarthy MI, Karpe F, Lindgren CM, Zondervan KT. Coexpression Network Analysis in Abdominal and Gluteal Adipose Tissue Reveals Regulatory Genetic Loci for Metabolic Syndrome and Related Phenotypes. PLoS Genetics 2012;8:e1002505

• Nnoaham KE, Hummelshoj L, Webster P, d'Hooghe T, de Cicco Nardone F, de Cicco Nardone C, Jenkinson C, Kennedy SH, Zondervan KT; World Endometriosis Research Foundation Global Study of Women's Health consortium. Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries. Fertility & Sterility 2011;96:366-373.

• International Endometriosis Genomics Consortium: Collaborative Genome-wide Association Studies of Endometriosis

• ENDOX: Prospective dense phenotyping & biological sampling study of women undergoing a laparoscopy in Oxford

• WERF EPHect: Endometriosis Phenotyping and Biobanking Harmonisation Project (endometriosisfoundation.org/ephect)

• World Endometriosis Society Board member (Secretary)

• Chair, World Endometriosis Society Research Directions Working Group

• Wellbeing of Women Research Advisory Committee

• Scientific Advisory Board member of the Boston Center for Endometriosis, Harvard Medical School and Brigham & Women's Hospital, Boston, USA

• Endometriosis Scientific Advisory Board member for AbbVie Inc, Bayer HealthCare, and Roche Diagnostics

• Examples:

• http://www.bbc.co.uk/news/health-11969075

• http://www.nhs.uk/news/2010/12December/Pages/endometriosis-genetics-explored.aspx

• http://www.phgfoundation.org/news/6928/

• http://www.well.ox.ac.uk/dec-10-genetic-variants-in-endometriosis

• MSc Biomedical Sciences (1995), Leiden University, The Netherlands

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