Dr. Iris Altpeter
Engineering and engineering trades , Physical sciences, Micromagnetic testing methods
University of Ljubljana, Slovenia
Physical sciences
Structural Biology
Structural biology of muscle actin-based cytoskeleton
Structure-function analysis of metallo-enzymes involved in protection from chemical and oxidative damage
English, French, Italian, Serbian
Grison, M., Merkel, U., Kostan, J., Djinović-Carugo, K., and Rief, M. (2017) alpha-Actinin/titin interaction: A dynamic and mechanically stable cluster of bonds in the muscle Z-disk. Proc Natl Acad Sci U S A 114, 1015-1020
Song, J. G., Kostan, J., Drepper, F., Knapp, B., de Almeida Ribeiro, E., Jr., Konarev, P. V., Grishkovskaya, I., Wiche, G., Gregor, M., Svergun, D. I., Warscheid, B., and Djinovic-Carugo, K. (2015) Structural Insights into Ca-Calmodulin Regulation of Plectin 1a-Integrin beta4 Interaction in Hemidesmosomes. Structure 23, 1-13
Ribeiro, E. D., Jr., Pinotsis, N., Ghisleni, A., Salmazo, A., Konarev, P. V., Kostan, J., Sjoblom, B., Schreiner, C., Polyansky, A. A., Gkougkoulia, E. A., Holt, M. R., Aachmann, F. L., Zagrovic, B., Bordignon, E., Pirker, K. F., Svergun, D. I., Gautel, M., and Djinovic-Carugo, K. (2014) The Structure and Regulation of Human Muscle alpha-Actinin. Cell 6, 1447-1460
Kostan, J., Salzer, U., Orlova, A., Toro, I., Hodnik, V., Senju, Y., Zou, J., Schreiner, C., Steiner, J., Merilainen, J., Nikki, M., Virtanen, I., Carugo, O., Rappsilber, J., Lappalainen, P., Lehto, V. P., Anderluh, G., Egelman, E. H., and Djinovic-Carugo, K. (2014) Direct interaction of actin filaments with F-BAR protein pacsin2. EMBO Rep 15, 1154-1162
de Almeida Ribeiro, E., Jr., Beich-Frandsen, M., Konarev, P. V., Shang, W., Vecerek, B., Kontaxis, G., Hammerle, H., Peterlik, H., Svergun, D. I., Blasi, U., and Djinović-Carugo, K. (2012) Structural flexibility of RNA as molecular basis for Hfq chaperone function. Nucleic Acids Res 40, 8072-8084
Galkin, V. E., Orlova, A., Salmazo, A., Djinović-Carugo, K., and Egelman, E. H. (2010) Opening of tandem calponin homology domains regulates their affinity for F-actin. Nat Struct Mol Biol 17, 614-616
Sjoblom, B., Polentarutti, M., and Djinović-Carugo, K. (2009) Structural study of X-ray induced activation of carbonic anhydrase. Proc Natl Acad Sci U S A 106, 10609-10613
Wuerges, J., Lee, J. W., Yim, Y. I., Yim, H. S., Kang, S. O., and Djinović-Carugo, K. (2004) Crystal structure of nickel-containing superoxide dismutase reveals another type of active site. Proc Natl Acad Sci U S A 101, 8569-8574
Djinović-Carugo, K., Young, P., Gautel, M., and Saraste, M. (1999) Structure of the alpha-actinin rod: molecular basis for cross-linking of actin filaments. Cell 98, 537-546
Djinović-Carugo, K., Banuelos, S., and Saraste, M. (1997) Crystal structure of a calponin homology domain. Nat Struct Biol 4, 175-179
Bordo, D., Djinovic, K., and Bolognesi, M. (1994) Conserved patterns in the Cu,Zn superoxide dismutase family. J Mol Biol 238, 366-386
Djinović, K., Gatti, G., Coda, A., Antolini, L., Pelosi, G., Desideri, A., Falconi, M., Marmocchi, F., Rotilio, G., and Bolognesi, M. (1992) Crystal structure of yeast Cu,Zn superoxide dismutase. Crystallographic refinement at 2.5 A resolution. J Mol Biol 225, 791-809
Structure, Function and Regulation of the Myofibrillar Z‐disc Interactome
An integrated approach to the muscle Z‐disk: from atomic structure to human disease
Vice-coordinator of PhD Programme Integrative Structural Biology, since 2016
Elected EMBO member, 2016
Member of appointment committee for Scientific Director of MFPL, Univ. of Vienna, Austria, 2015
Member of User Committee of the "Protein Technology Facilities" at the Vienna Biocenter Campus Facility (VBCF), since 2011
Head of Department for Structural and Computational Biology, Univ. of Vienna, Austria, since 2009
Member of habilitation committees (3x head of committee) Univ. of Vienna, Austria, since 2004
Member of appointment committees (2x head of committee) or reviewer for selection of new professors at the Univ. of Vienna and Univ. of Graz, Austria, since 2004
Member of International Advisory Board of Malopolska Center of Biotechnology, Krakow, Poland, since 2017
Member of Scientific Advisory Board of the Czech Infrastructure for Integrative Structural Biology (CIISB), since 2016
Member of Scientific Advisory Board of Neutrons and Synchrotron Radiation (NESY), since 2016
Member of Scientific Advisory Board of Max IV Swedish Synchrotron Facility, since 2013
Member of Project Evaluation Panel of EMBL Hamburg, 2012
Member of Project Evaluation Panel of BioStruct-X, 2012 – 2016
Member of Project Evaluation Panel of Max IV Swedish Synchrotron Facility, 2013 – 2015
Elected member of Board of Austrian Science Fund (FWF), 2011 – 2014
Member of Scientific Advisory board of French Synchrotron facility Soleil, 2012 – 2014
Vice-speaker of PhD Programme Structure and Interaction of Biological Macromolecules, 2009 – 2013
Member of ESRF Review Committee in area of Macromolecular Crystallography, 2008 – 2011
Member of Scientific Advisory Council of the Centre of Excellence in Biocrystallography (CEB) at the University of Trieste, Italy, 2001 – 2004
Member of the Editorial Board of Journal Muscle Research and Cell Motility, since 2015
Associated Editor of Science Frontiers Molecular Biosciences, since 2014
J. Mol. Biol., Structure, Acta Cryst., J. Biol. Chem., FEBS Letters, BBA Proteins and Proteomics, Mol. Biol. Evol., Proteins, Protein Science, PLoS Biology, J. Muscle Res. Cell Motil.
DFG (Germany), ANR (France), EC-FP7, EC-FP6 (European Community), ARRS (Slovenia), NOW (The Netherlands), CIVR (Italy), AIRC (Italy), BBSRC (UK), MRC (UK), Portuguese Foundation for Science and Technology (PT), ERC (European Community), For PhD theses from foreign universities: Sweden, Italy, Germany, Slovenia, Norway, EMBL, Finland
Organizer (with K. Hradil and R. Miletich) of 32nd European Crystallographic Meeting, Vienna, Austria (expected >1000 participants), 2019
Scientific organizer (with S.Kojic and M. Gautel) of Conference Structure and Dynamics of the Sarcomere, Belgrade, Serbia (70 participants), 2016
Scientific organizer (with S. Galler) of European Muscle Conference, Salzburg, Austria (350 participants), 2014
Scientific organizer (with M. Gautel, D. Fuerst, M. Wilmanns) of Conference Z-disk structure and dynamics, Hamburg, Germany (70 participants), 2013
Scientific organizer of the 16th Heart of Europe Bio-crystallography Meeting (HEC-16), Attersee, Austria (120 participants), 2013
Scientific organizer (with M. Weiss and S. McSweany) of 4th Winter School on Soft X-rays in Macromolecular Crystallography, Grenoble, France (50 participants), 2012
Scientific organizer (with M. Weiss and U. Mueller) of Workshop on Data Collection using synchrotron radiation (Berlin, Germany) (25-30 participants each), 2007, 2009, 2011, 2013, 2016
Scientific organizer (together with M. Weiss and U. Mueller) of Winter School on Soft X-rays in Macromolecular Crystallography, Berlin, Germany (50 participants), 2009
Scientific organizer (with Jacques Rohayem, Eric Snijder, Johan Neyts, Paul Tucker) of an EMBO workshop: 'RNA viruses: replication, evolution and drug design' – cosponsored by VIZIER, Vienna, Austria (90 participants), 2007
Scientific organizer of the Winter School on Phasing with Soft X-rays, Seefeld, Austria (40 participants), 2006
Co-organizer (with Manfred Weiss, EMBL-Hamburg, DE) of Workshop: Validation of Structures and Structure Determination Steps, Elettra, Trieste, Italy (40 participants), 2003
Co-organizer of the Winter School on Phasing with Soft X-rays, Bressanone/Brixen, Italy, 2003
Co-organizer (with Keith Wilson, York, UK) of the Seventh International School on the Crystallography of Biological Macromolecules, Como, Italy (120 participants), 2003
Organizer of Workshop: Challenges in Crystallography of Macromolecular Assemblies, Elettra, Trieste, Italy (40-50 participants), 2000
Invited talk, 30th European Crystallographic Meeting, Basel, Switzerland, 2016
Invited talk, Conference of Structure and Dynamics of the Sarcomere, Belgrade, Serbia, 2016
Keynote Lecture CRYSTAL30, Society of Crystallographers of Australia and New Zealand, Hobart, Australia , 2016
Invited talk, 3rd Annual Congress of The European Society for Translational Medicine, Vienna, Austria, 2015
Invited talk, American Crystallographic Association, Philadelphia, US, 2015
Invited talk, International Union of Crystallography, Montreal, Canada, 2014
Plenary lecture Chemistry towards Biology, Trieste, Italy, 2013
Invited talk, European Muscle Conference, Rhodes, Greece, 2012
Invited talk, 27th European Crystallographic Meeting, Bergen, Norway, 2012
Invited talk, Joint Meeting of DFG Research Groups: Cross-striated Muscle in Health and Disease, Bonn, Germany, 2011
Invited talk, 9th European Biological Inorganic Chemistry Conference, Wroclaw, Poland, 2008
Invited talk, 12. Membrane Skeleton Recent Advances and Future Research Directions, Zakopane, Poland, 2008
Since 1999 I have raised a total of 5.6 million Euros as PI with grants from funding agencies in Austria, Germany, Slovenia, United Kingdom and Europe (5th, 6th, 7th EU Framework Programmes) Coordinator of EU-FP5 RTD project “EXMAD” (2000-2004); Coordinator of EU-FP7 ITN “MUZIC”; Coordinator of Laura Bassi “Center for Optimised Structural Studies” (2010-2016); joint director of Christian Doppler Laboratory for High-Content Structural Biology and Biotechnology (since 2017); member of Wellcome Trust Collaborative Award (since 2016).
positive attitude, flexibility, communication AND listening
Married to Oliviero Carugo, structural bioinformatics expert
one child (born 1994)
Visual arts, literature; yoga, pilates
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Engineering and engineering trades , Physical sciences, Micromagnetic testing methods
Physical sciences
Physical sciences, Preparative and physical chemistry of polymersNanotechnology
Biological and related sciences , Physical sciences, Environmental virology, Molecular and structural biology, biochemistry