Prof. Dr. Manuela Baccarini

• Manuela Baccarini is Professor of Cell Signaling at the University of Vienna, coordinator of the International PhD Program "Signaling Mechanisms in Cellular Homeostasis" and of the Vienna Doctoral School "Molecules of Life" at MFPL. Baccarini is EMBO member and corresponding member of the Austrian Academy of Sciences. She is a graduate of the University of Rome 'La Sapienza' (1987). After postdoctoral stays with Marie-Luise Lohmann-Matthes at the Max-Planck-Institute for Immunobiology in Freiburg Germany) and with E. Richard Stanley at the Albert Einstein College of Medicine in New York, she has been a group leader at the Fraunhofer Institute in Hannover (Germany) and Associate Professor at the Department of Microbiology, Immunbiology and Genetics of the University of Vienna. She was Deputy Director of the Center for Molecular Biology at the Max F. Perutz Laboratories from 2007 to 2017.

  The Baccarini group has a longstanding interest in the regulation and in the physiological role of the MAPK pathway. Recently, the group has performed the conditional and conventional knockout of the Raf kinases and of their effectors Mek. The knockout studies have defined essential in vivo roles of these proteins, several of which are unexpectedly independent of their enzymatic activity, and have changed the way we look at the pathway. The lab continues to focus on deciphering signaling pathways in vivo by conditional gene ablation in the mouse.

• Ehrenreiter, K., F. Kern, V. Velamoor, K. Meissl, G. Galabova-Kovacs, M. Sibilia, and M. Baccarini (2009): Raf-1 addiction in Ras-induced carcinogenesis. In: Cancer Cell, 16, 149-160 [Abstract PubMed] [Cancer Cell Preview by Dafna Bar-Sagi] [Faculty of 1000 recommended]

• Catalanotti, F., G. Reyes, V. Jesenberger, G. Galabova-Kovacs, R. de Mato Simoes, O. Carugo, and M. Baccarini (2009): A MEK1-MEK2 heterodimer determines the strength and duration of the ERK signal. In: Nat Struct Mol Biol 16, 294-303 [Abstract PubMed] [Faculty of 1000 must read] [Nature signaling update feature]

• Zmajkovicova, K, V. Jesenberger, F. Catalanotti, C. Baumgartner, G. Reyes, and M. Baccarini (2013). MEK1 Is Required for PTEN Membrane Recruitment, AKT Regulation, and the Maintenance of Peripheral Tolerance. In: Mol Cell 50, 43-55 [Faculty of 1000 prime recommended]

• Desideri, E., A.L. Cavallo, and M. Baccarini (2015). Alike but Different: RAF Paralogs and Their Signaling Outputs. Cell 16, 967-970.

• Member of the New Investigator Awards Selection Panel – Cancer Research UK , since 2011

• ERC advanced grants Panel Member – European Research Council, Belgium, 2011 – 2015

• Erasmus Coordinator – Center of Molecular Biology, since 2010

• Chair of the Steering Committee – EU FP6 Project GROWTHSTOP – Medical University of Innsbruck, Austria, 2006 – 2010

• External reviewer panel – Quinquennial Review of the Centre for Cell and Molecular Biology at the Institute of Cancer Research in London – Cancer Research UK, 2008

• Steering Committe Member – EU FP6 Project INTACT, BRIC, Copenhagen, Denmark, 2004 – 2008

• Group Leaders Assessment committee – BRIC – Biotech Research and Innovation Centre, University of Copenhagen, Denmark, 2007

• Preferred Referees Pool – Associazione Italiana per la Ricerca sul Cancro, Italien, since 2006

Advisory Boards:

• Member of the external advisory board for the assessment of the planned Graduate School – Eberhard Karls Universität Tübingen, Deutschland, since 2010

• Advisory Board Member – Medical University of Innsbruck, Austria, since 2010

• Advisory Board Member – ONCOTYROL – Center for Personalized Medicine, Austria, since 2009

• Scientific Advisory Board – EU FP6 Project COSBICS, University of Rostock, Germany, 2005 – 2008

• Scientific Advisory Committee Member – Association for International Cancer Research (AICR), UK 2004 – 2009

Reviewer:

• Expert Reviewer, Evaluation of an Academy professor candidate – Research Council for Biosciences and Environment, Academy of Finland, Finland, since 2010

• Ad hoc reviewer for scientific journals and granting agencies including DFG, CR-UK, MRC, Swiss Cancer league, AIRC, AICR

• Corresponding member of the Austrian Academy of Sciences, since 2010

• Coordinator of the International PhD Program "Molecular Mechanisms of Cell Signaling", since 2009

• Deputy Director of the Center for Molecular Biology at the Max F. Perutz Laboratories, since 2007

Soft Skills

• Married, one daughter

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