Short CV/Education and training

  • 1988
    Diploma in Chemistry

  • 1981 – 1988
    Studies in Chemistry, RWTH Aachen, Germany

  • 1988 – 1991
    PhD thesis „Peptidanaloga des Anaphylatoxins C3a. Synthese und Strukturfunktionsbeziehungen“ at the Deutsche Wollforschungsinstitut, RWTH Aachen

  • 1991 – 1992
    Postdoc at the Deutsche Wollforschungsinstitut, RWTH Aachen

  • 1992 – 1994
    Postdoc at the Institute of Enzyme Technology (Prof. Dr. M.-R. Kula), Heinrich-Heine University Düsseldorf

  • 1994 – 2000
    Group leader ”Protein Design” at the Institute of Enzyme Technology, Heinrich-Heine University Düsseldorf

  • 2000
    Habilitation and venia legendi for Technical Biochemistry, Heinrich-Heine University of Düsseldorf

  • 2000 – 2002
    Research director responsible for downstream processing of transgenic proteins produced in plants and protein biochemistry at MPB Cologne GmbH, Cologne/Germany

  • 2003 – 2003
    Project management at the Projektträger Jülich, on behalf of the Federal Ministry for Science and Education (BMBF), Forschungszentrum Jülich GmbH

  • 2004 – 2009
    Group leader „Applied Enzyme Technology“, Institute of Molecular Enzyme Technology, Heinrich-Heine University Düsseldorf

  • 2008
    Appointment to extraordinary professorship, Heinrich-Heine University Düsseldorf

  • Since 2009
    Group leader “Biocatalysis & Biosensors”, Institute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülich GmbH

Selected publications

  • Okrob, D., M. Paravidino, R. V. A. Orru, W. Wiechert, U. Hanefeld and M. Pohl (2011): "Hydroxynitrile lyase from Arabidopsis thaliana: Identification of reaction parameters for enantiopure cyanohydrin synthesis by pure and immobilized catalyst." In: Adv. Synth. Catal. in press. DOI: 10.1002/adsc.201100199

  • Rother, D., G. Kolter, T. Gerhards, C. L. Berthold Siöberg, E. Gauchenova, M. Knoll, J. Pleiss, M. Müller, G. Schneider and M. Pohl (2011): "(S)-Selective mixed benzoin condensation by structure-based design of the pyruvate decarboxylase from Acetobacter pasteurianus." In: ChemCatChem in press. DOI: 10.1002/cctc.201100054

  • Franken, B., K. E. Jaeger, T. Eggert and M. Pohl (2011): "Mechanism of acetaldehyde-induced deactivation of microbial lipases." In: BMC Biochem. 12:10

  • Meyer, D., M. Pohl, M. Müller and K. Tittmann (2011): "Conversion of pyruvate decarboxylase into an enantioselective carboligase with biosynthetic potential." In: JACS 133: 3609-3616

  • Andexer, J. N., J. Von Langermann, U. Kragl and M. Pohl (2009): "How to overcome limitations in biotechnological processes – examples from hydroxynitrile lyase applications." In: Trends Biotechnol. 27: 599-607

  • Gocke, D., T. Graf, H. Brosi, I. Frindi-Wosch, L. Walter, M. Müller and M. Pohl (2009): "Comparative characterisation of thiamin diphosphate-dependent decarboxylases " In: J. Mol. Cat. B-Enzymatic 61: 30-35

  • Guterl, J. K., J. N. Andexer, T. Sehl, J. von Langermann, I. Frindi-Wosch, T. Rosenkranz, J. Fitter, K. Gruber, U. Kragl, T. Eggert and M. Pohl (2009): "Uneven Twins: Comparison of two enantiocomplementary Hydroxynitrile Lyases with α/β-Hydrolase Fold." In: J. Biotech. 141: 166-173

  • Gocke, D., L. Walter, E. Gauchenova, G. Kolter, M. Knoll, C. L. Berthold, G. Schneider, J. Pleiss, M. Müller and M. Pohl (2008): "Rational protein design of ThDP-dependent enzymes: engineering stereoselectivity." In: Chembiochem 9: 406-412. DOI: 10.1002/cbic.200700598

  • Andexer, J., J. von Langermann, A. Mell, M. Bocola, U. Kragl, T. Eggert and M. Pohl (2007): "A new (R)-selective hydroxynitrile lyase from Arabidopsis thaliana with an α/β-hydrolase fold." In: Angew. Chem. Int. Ed. 46: 8679-8681. DOI: 10.1002/anie.200701455

  • Knoll, M., M. Müller, J. Pleiss and M. Pohl (2006): "Factors mediating activity, selectivity, and substrate specificity for the thiamin diphosphate-dependent enzymes benzaldehyde lyase and benzoylformate decarboxylase." In: Chembiochem 7: 1928-1934. DOI: 10.1002/cbic.200600277


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