Prof. Avan Aihie Sayer
Health, Academic Medicine
Health
Laboratory Medicine, Hematology/Oncology, Hemostaseology, Immunology
The role of chemokine receptors in tumor formation and in immunological processes:
- processes of tumour cell transformation, angiogenesis and metastasis
- influence of the microenvironment on tumor progression and chemotherapy resistance
- tumor stem cells
- migration and homoeostasis of immune cells
Emmy Noether fellowship from the German Research Foundation (DFG), 2000 – 2004
Travel award from the American Society for Hematology and Oncology, 1998
Postdoc fellowship from the German Research Foundation (DFG), 1996 – 1999
Fellowship from the University of Freiburg Scientific Society, 1995
English, German
Taromi S, Kayser G, Catusse J, von Elverfeldt D, Reichardt W, Braun F, Weber WA, Zeiser R, Burger M (2016). CXCR4 antagonists suppress Small Cell Lung Cancer progression. Oncotarget. 2016 Dec 20;7(51):85185-85195.
Taromi S, Kayser G, von Elverfeldt D, Reichardt W, Braun F, Weber WA, Zeiser R, Burger M. (2016) An orthotopic mouse model of small cell lung cancer reflects the clinical course in patients. Clin Exp Metastasis. 2016 Oct;33(7):651-60.
Krohn A, Ahrens T, Yalcin A, Plönes T, Wehrle J, Taromi S, Wollner S, Follo M, Brabletz T, Mani S, Claus R, Hackanson B, Burger M (2014) Tumor Cell Heterogeneity in Small Cell Lung Cancer (SCLC): Phenotypical and Functional Differences Associated with Epithelial-Mesenchymal Transition (EMT) and DNA Methylation Changes. PLosOne Jun 24;9(6):e100249
Catusse J, et.al. Role of the atypical chemoattractant receptor CRAM in regulating CCL19 induced CCR7 responses in B-cell chronic lymphocytic leukemia. In: Mol Cancer. 2010 Nov 22;9:297.
Catusse, J. et al.: Attenuation of CXCR4 responses by CCL18 in acute lymphocytic leukemia B-cells. In: J Cell Physiol. 2010 Nov;225(3):792-800.
Leick, M. et al.: CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B. In: Immunology 129(4), 2010. S. 536-46.
Hartmann, T.N. et al.: CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells. In: Oncogene 24, 2005. S. 4462-4471.
Burger, M. et al. (2005): Small Peptide Inhibitors of the CXCR4 Chemokine Receptor (CD184) Antagonize the Activation, Migration and Antiapoptotic Responses of CXCL12 in Chronic Lymphocytic Leukemia B Cells. In: Blood 106(5), 2005. S. 1824-30.
Burger, M. et al.: KSHV-GPCR and CXCR2 transforming capacity and angiogenic responses are mediated through a Jak2-STAT3 dependent pathway. In: Oncogene 24, 2005. S. 2067-2075.
Burger, M. et al.: Functional expression of CXCR4 (CD184) on small cell lung cancer cells (SCLC) mediates migration, integrin activation, and adhesion to stromal cells. In: Oncogene 22, 2003. S. 8093-8101.
Burger, M. et al.: Point mutation causing constitutive signaling of CXCR2 leads to transforming activity similar to Kaposi's sarcoma herpesvirus-G protein-coupled receptor. In: J. Immunol 163(4), 1999. s. 2017-22.
project C3: The Chemokine receptor CXCR4 in Small Cell Lung Cancer (SCLC) and its role in metastasis (SFB 850: Control of cell motility in morphogenesis, cancer invasion and metastasis)
project B5: Role of chemokine receptors in B cell maturation processes (Translational research platform of the Center for Chronic Immunodeficiency)
German Society for Hematology and Oncology (DGHO)
German Society for Immunology (DGfI)
Society for Signal Transduction
German Association of University Professors and Lecturers (Deutscher Hochschulverband, DHV)
international peer reviewed journals
scientific bodies, e.g. DFG
Health, Academic Medicine
Biological and related sciences, Health, Cell Biology, Cellular and Molecular Neuroscience, Vascular Biology, Tumour Biology
Biological and related sciences, Health
Health, Public Health