Short CV/Education and training

  • Since 2021:

    Full Professor, Global Health Institute, School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland

  • 2016-2021:

    Associate Professor (tenured), Global Health Institute, School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland

  • 2009-2016:

    Tenure-track Assistant Professor, Global Health Institute, School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland

  • 2005-2009:

    Postdoctoral Fellow; Division of Infectious Diseases and Geographic Medicine, Department of Microbiology & Immunology, Stanford University, CA, USA

  • 2000-2004:

    PhD in Biology (doctoral degree / Dr. rer. nat.); Department Biology I, Microbiology, Ludwig-Maximilians-University, Munich, Germany

  • 1995-2000:

    Diploma in Biology; Microbiology (major), Genetics, Medical Microbiology, Immunology (minors), Ludwig-Maximilians-University, Munich, Germany

Selected publications

  • Jaskólska M.*, Adams D.W.*, Blokesch M. (2022) Two defence systems eliminate plasmids from seventh-pandemic Vibrio cholerae. Nature, 604:323-329 (*equal contribution)

  • Drebes Dörr N.C., Proutière A., Jaskólska M., Stutzmann S., Bader L., Blokesch M. (2022) Single nucleotide polymorphism determines constitutive versus inducible type VI secretion in Vibrio cholerae. ISME J.; doi:10.1038/s41396-022-01234-7

  • Vesel N., Blokesch M. (2021) Pilus production in Acinetobacter baumannii is growth phase dependent and essential for natural transformation. J. Bacteriol., 203:e00034-21.

  • Matthey N., Stutzmann S., Stoudmann C., Guex N., Iseli C., Blokesch M. (2019) Neighbor predation linked to natural competence fosters the transfer of large genomic regions in Vibrio cholerae. eLife 8:e48212.

  • Adams D.W., Stutzmann S., Stoudmann C., Blokesch M. (2019) DNA-uptake pili of Vibrio cholerae are required for chitin colonisation and capable of kin recognition via sequence-specific self-interaction. Nat. Microbiol., 4:1545-1557.

  • Van der Henst C., Vanhove A.S., Drebes Dörr N.C., Stutzmann S., Stoudmann C., Clerc S., Scrignari T., Maclachlan C., Knott G., Blokesch M. (2018) Molecular insights into Vibrio cholerae’s intra-amoebal host-pathogen interactions. Nat. Commun., 9:3460. doi: 10.1038/s41467-018-05976-x.

  • Jaskólska M., Stutzmann S., Stoudmann C., Blokesch M. (2018) QstR-dependent regulation of natural competence and type VI secretion in Vibrio cholerae. Nucleic Acids Res., 46:10619-10634.

  • Metzger L.C., Stutzmann S., Scrignari T., Van der Henst C., Matthey N., Blokesch M. (2016) Independent regulation of type VI secretion in Vibrio cholerae by TfoX and TfoY. Cell Rep., 15:951-958.

  • Van der Henst C., Scrignari T., Maclachlan C., Blokesch M. (2016) An intracellular replication niche for Vibrio cholerae in the amoeba Acanthamoeba castellanii. ISME J., 10:897-910.

  • Borgeaud S., Metzger L.C., Scrignari T., Blokesch M. (2015) The type VI secretion system of Vibrio cholerae fosters horizontal gene transfer. Science, 347:63-67.

  • Kühn J., Finger F., Bertuzzo E., Borgeaud S., Gatto M., Rinaldo A., Blokesch M. (2014) Glucose- but not rice-based oral rehydration therapy enhances the production of virulence determinants in the human pathogen Vibrio cholerae. PLoS Negl. Trop. Dis., 8: e3347.

  • Seitz P., Pezeshgi Modarres H., Borgeaud S., Bulushev R.D., Steinbock L.J., Radenovic A., Dal Peraro M., Blokesch M. (2014) ComEA Is Essential for the Transfer of External DNA into the Periplasm in Naturally Transformable Vibrio cholerae Cells. PLoS Genet., 10: e1004066.

  • Seitz P., Blokesch M. (2013) DNA-uptake machinery of naturally competent Vibrio cholerae. Proc. Natl. Acad. Sci. USA, 110:17987-92.

  • Lo Scrudato M., Blokesch M. (2013) A transcriptional regulator linking quorum sensing and chitin induction to render Vibrio cholerae naturally transformable. Nucleic Acids Res., 41: 3644-58.

  • Seitz P., Blokesch M. (2013) Cues and regulatory pathways involved in natural competence and transformation in pathogenic and environmental Gram-negative bacteria. FEMS Microbiol. Rev., 37:336-63.

  • Lo Scrudato M., Blokesch M. (2012) The Regulatory Network of Natural Competence and Transformation of Vibrio cholerae. PLoS Genet., 8: e1002778.

  • Blokesch M., Schoolnik G.K. (2007) Serogroup Conversion of Vibrio cholerae in Aquatic Reservoirs. PLoS Pathog., 3:e81, 733-742.

  • Meibom K.L.*, Blokesch M.*, Dolganov N.A., Wu C.-Y., Schoolnik G.K. (2005) Chitin induces natural competence in Vibrio cholerae. Science, 310:1824-1827. (* equal contribution)

Complete list of publications

Membership in scientific bodies/juries

  • Association for General and Applied Microbiology (VAAM; Germany)

  • American Society for Microbiology (ASM; USA)

  • Swiss Society for Microbiology (SSM; Switzerland)

  • International Society for Microbial Ecology (ISME; international)

Media coverage

Additional qualifications

  • Nominated by ETH Board as tenure-track Assistant Professor (2009) and as tenured Associate Professor (2016) and Full Professor (2021) working at the Swiss Federal Institute of Technology in Lausanne (École Polytechnique Fédérale de Lausanne, EPFL)


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  1. Melanie Blokesch elected International Research Scholar

    The AcademiaNet scientist is one of 41 international researchers whose work will be supported by a 650 000 $ grant.

  2. ERC Consolidator Grant for Melanie Blokesch

    Melanie Blokesch from the Swiss Federal Institute of Technology in Lausanne gets the ERC Consolidator Grant to uncover the path of transmission of cholera bacteria from the environment to humans.

  3. Stéphanie Lacour and Melanie Blokesch: Professors at EPFL Lausanne

    Both AcademiaNet members were appointed Associate Professors, Melanie Blokesch of Life Sciences and Stéphanie Lacour of Microtechnology and Bioengineering.

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