Prof. Dr. Minka Breloer

• 2019
  Appointed §17 Professor at the University of Hamburg
  
  

• 2010
  Habilitation at the University of Hamburg (Award of the Venia Legendi at the University Hamburg Faculty of Mathematics, Informatics and Natural Sciences for the subject Zoology with Focus on Immunology)
  
  

• Since 2007
  Group leader of the laboratory "helminth immunology" at the Bernhard Nocht Institute for Tropical Medicine. Major Topic: Nematode infections in mice: immune response and immune modulation
  
  

• 2007
  Graduated as Expert Immunologist by the German Society for Immunology
  
  

• 2002 – 2007
  Senior Postdoc at the Department of Immunology, Bernhard Nocht Institute for Tropical Medicine. Major Topic: Characterization of the immunological function of the transmembrane protein CD83
  
  

• 2002
  Parental leave
  
  

• 1999 – 2001
  Junior Postdoc at the Department of Immunology, Bernhard Nocht Institute for Tropical Medicine. Major Topic: Immune stimulatory functions of autologous HSP60
  
  

• 1995 – 1999
  Graduated as Dr. rer. nat. at the University Hamburg, Faculty of Biology.
  
  

• 1994 – 1995
  Graduated with a diploma in Biology. Topic: "Einfluss des "XP-Motivs" auf die Antigenpräsentation von I-Ad assoziierten Ovalbumin-Peptiden" (very good: 1.0)
  
  

• 1989 – 1995
  Academic studies at the University of Hamburg
  
  

• Meiners J, Reitz M, Rüdiger N, Turner JE, Heepmann L, Rudolf L, Hartmann W. McSorley HJ, Breloer M. IL-33-facilitates rapid expulsion oft he parasitic nematode Strongyloides ratti from the intestine via ILC2- and IL-9-driven mast cell activation. PLoS Pathogens 2020, 16(12): e1009121.

• Hartmann W, Brunn M-L, Stetter N, Gagliani N, Muskate F, Stanelle-Bertram S, Gabriel G, and

  Breloer M, Helminth infections suppress the efficacy of vaccination against seasonal influenza. Cell Reports 2019 29, 2243-2256.

• Delacher M, Schmidl C, Herzig Y, Breloer M, Hartmann W, Brunk F, et al. Rbpj expression in regulatory T cells is critical for restraining TH2 responses. Nature Communication 2019; 10(1):1621.

• Reitz M, Brunn ML, Rodewald HR, Feyerabend TB, Roers A, Dudeck A, Voeringer D, Jönsson F, Kühl AA and Breloer M. Mucosal mast cells are indispensable for timely termination of Strongyloides ratti infection. Mucosal Immunology 2017; 10: 481-492.

• Breloer M, Hartmann W, Blankenhaus B, Eschbach ML, Pfeffer K and Jacobs T. Cutting Edge: the BTLA-HVEM regulatory pathway interferes with protective immunity to intestinal Helminth infection. Journal of Immunology 2015; 194: 1413-1416.

• Ulges A, Klein M, Reuter S, Gerlitzki B, Hoffmann M, Grebe N, Staudt V, Stergiou N, Bohn T, Brühl TJ, Muth S, Yurugi H, Rajalingam K, Bellinghausen I, Tuettenberg A, Hahn S, Reißig S, Haben I, Zipp F, Waisman A. Probst HC, Beilhack A, Buchou T, Filhol-Cochet O, Boldyreff B, Breloer M, Jonuleit H, Schild H, Schmitt E and Bopp T. Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo. Nature Immunology 2015; 16: 267-275.

• Hartmann W, Schramm C and Breloer M. Litomosoides sigmodontis induces TGF-beta receptor responsive, IL-10-producing T cells that suppress bystander T-cell proliferation in mice. European Journal of Immunology 2015; 45:2568.

• Blankenhaus B, Reitz M, Brenz Y, Eschbach ML, Hartmann W, Haben I, Sparwasser T, Huehn J,

  Kühl A, Feyerabend TB, Rodewald HR and Breloer M. Foxp3(+) regulatory T cells delay expulsion of intestinal nematodes by suppression of IL-9-driven mast cell activation in BALB/c but not in C57BL/6 mice. PLoS Pathogens 2014; 10: e1003913.

• Hartmann W, Haben I, Fleischer B and Breloer M. Pathogenic nematodes suppress humoral responses to third-party antigens in vivo by IL-10-mediated interference with Th cell function. Journal of Immunology 2011; 187: 4088-4099.

• Blankenhaus B, Klemm U, Eschbach ML, Sparwasser T, Huehn J, Kühl AA, Loddenkemper C, Jacobs T and Breloer M. Strongyloides ratti infection induces expansion of Foxp3+ regulatory T cells that interfere with immune response and parasite clearance in BALB/c mice. Journal of Immunology 2011; 186: 4295-4305.

• One third of the world population is infected with parasitic worms. These parasites delay or avoid elimination by dampening the immune responses of their hosts. Our group uses murine models of worm infections to investigate i) the nature of a protective anti-worm immune response, ii) the mechanisms of worm-induced immune modulation, and iii) the impact of concurrent worm infection on other immune responses in situations of co-infection or vaccination.

• Graduated as Expert Immunologist (Fachimmunologin) by the German Society for Immunology, April 2007

• Appointed §17 Professor at the University of Hamburg, May 2019

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