Short CV/Education and training

  • Prof. Dr. Marquez-Lago is affiliated with The University of Alabama at Birmingham (UAB) School of Medicine. She is an Associate Professor of Genetics, and an Associate Professor of Cell, Developmental and Integrative Biology. Additionally, she is affiliated with the Comprehensive Cancer Center at UAB.

Selected publications

  • Chen, Z. et al. (2018) iFeature: a python package and web server for features extraction and selection from protein and peptide sequences

    Bioinformatics bty 140

  • Botta, D. et al. (2017) Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection. Nature Immunology 18, 1249-1260

  • Buono, R.A. et al. (2017) ESCRT-mediated vesicle concatenation in plant endosomes. J. Cell Biol. Vol 216, No. 7

  • You, C., Marquez-Lago, T. et al. (2016). Receptor dimer stabilization by hierarchical plasma membrane microcompartmets regulates cytokine signaling. Science Advances Vol. 2, No. 12, e1600452

  • An, Y., et al. (2016) Comprehensive assessment and performance improvement of effector protein predictors for bacterial secretion systems III, IV and VI. Brief. Bioinform bbw100:1-14

  • Leier, A. and Marquez-Lago, T. (2015) Delay chemical master equation: direct and closed-form solutions. Proc. Royal Society A 471:20150049

  • Zavala, E. and Marquez-Lago, T. (2014) The Long and Viscous Road: Uncovering Nuclear Diffusion Barriers in Closed Mitosis. PLoS Computational Biology 10(7): e1003725

  • Leier, A., Barrio, M. and Marquez-Lago, T. (2014) Exact model reduction with delays: closed-form distributions and extensions to fully bi-directional monomolecular reactions. J. Royal Society Interface 11: 20140108

  • Boettcher, B. *, Marquez-Lago, T. *, Bayer, M., Weiss, E., Barral, Y. (2012) Nuclear envelope morphology constrains diffusion and promotes asymmetric protein segregation in closed mitosis. J. Cell Biol. Vol. 197, Number 7: 921-937.

  • Leier, A., and Marquez-Lago, T. (2011) Correction factors for boundary diffusion and bimolecular reactions in reaction-diffusion master equations. J Chem Phys 135, 134109

  • Tigges, M., Marquez-Lago, T., Stelling, J. and Fussenegger, M. (2009) A tunable synthetic mammalian oscillator. Nature, 457: 309-312.

Complete list of publications

Selected projects

  • Prof. Dr. Marquez-Lago's research is driven by fundamental problems in biology and (bio)medicine, with a focus on building quantitative, predictive models. We incorporate multi-scale modelling and simulations, artificial intelligence (AI), bioengineering, and both micro- and molecular biology tools to investigate (1) host-microbiota interactions in complex human diseases, (2) microbial multi-drug resistance, and (3) gene expression and chromatin organization. In addition, we study (4) the role and effect of mechanical forces ('mechanicanobiology') and cell compartmentalization in pathogenesis.

  • Her lab combines cutting edge modeling and simulation techniques with experimental design and analysis of experimental data. This data includes DNA/RNA/ATAC/ChIP-seq, metabolomics, proteomics, super-resolution microscopy and more. Many of the questions she and her lab address involve the integration of these data into fully calibrated models that have predictive power, revealing testable experiments in fundamental biology and translational research, primarily aimed at identifying effective biomarkers and viable precision therapeutics

Membership in scientific bodies/juries

  • Member of:

    - Society for Mathematical Biology

    - International Society for Computational Biology

    - Biophysical Society

    - SIAM

    - American Physical Society

  • Alumni:

    - Swiss Institute of Bioinformatics

Additional qualifications

  • Senior Post-Doctoral Research Fellow. Department of Biosystems Science and Engineering, ETH Zurich, Switzerland

  • Post-Doctoral Research Fellow. Advanced Computational Modelling Centre, The University of Queensland, Australia

    Mentor: Prof. Kevin Burrage (Director, now at University of Oxford)

  • Graduate Research Assistant. NIGMS/NIH Center for Spatiotemporal Modeling of Cell Signaling, University of New Mexico, USA. STMC National Center for Systems Biology. Mentors: Prof. Stanly Steinberg and Prof. Janet Oliver (Founding Directors)

Soft Skills/Other activities and achievements

Soft Skills

  • Formally trained in International Business Management


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