Short CV/Education and training

  • 1984
    Diplom degree in biochemistry, Martin Luther University Halle-Wittenberg, Germany

  • 1991
    Expert scientist in biochemistry in medicine

  • 1991
    Doctor of Natural Science (Dr. rer. nat.), Humboldt University, Berlin, Germany

  • 1991 – 1993
    Postdoc, Max Delbrück Centre for Molecular Medicine (MDC), Berlin

  • 1994 – 1995
    Postdoc, National Cancer Institute, Frederick, MD, USA

  • 1996 – 2000
    Team leader (research unit surgical oncology), Max Delbrück Centre for Molecular Medicine (MDC), Berlin

  • 2001 – 2006
    Team leader (research unit surgical oncology), Robert Rössle Clinic, Charité, Berlin

  • 2003
    Habilitation (postdoctoral qualification), Charité Universitätsmedizin, Berlin

  • Since 2007
    Team leader (research unit surgical oncology), Experimental and Clinical Research Centre, Charité, Berlin

  • 2009
    Professor, Charité Universitätsmedizin, Berlin

  • Alumni visiting researcher at the National Cancer Institute, Frederick, MD, USA, 1996, 1997, 1998, 2001, 2003, 2007, 2011

Selected publications

  • Stein, U, Arlt, F, Walther, W, Smith, J, Waldman, T, Harris, ED, Mertins, SD, Heizmann, CW, Allard, D, Birchmeier, W, Schlag, PM, & Shoemaker RH. (2006) The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor signaling in colon cancer. Gastroenterology, 131,1486-1500.

  • Stein, U, Walther, W, Arlt, F, Schwabe, H, Smith, J, Fichtner, I, Birchmeier, W, & Schlag, PM. (2009) MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis. Nat Med, 15,59-67.

  • Stein, U, Smith, J, Walther, W, & Arlt, F. (2009) MACC1 controls Met ? what a difference an Sp1 site makes. Cell Cycle, 8,2467-2469.

  • Stein, U, Dahlmann, M, & Walther, W. (2010) MACC1 ? more than metastasis? Facts and predictions about a novel gene. J Mol Med, 88,11-18.

  • Sack, U, Walther, W, Scudiero, D, Selby, M, Aumann, J, Lemos, C, Fichtner, I, Schlag, PM, Shoemaker, RH, & Stein U. (2011) S100A4-induced cell motility and metastasis is restricted by the Wnt/?-catenin pathway inhibitor calcimycin in colon cancer cells. Mol Biol Cell, 22,3344-3354.

  • Stein, U, Arlt, F, Smith, J, Sack, U, Herrmann, P, Walther, W, Lemm, M, Fichtner, I, Shoemaker, RH, & Schlag PM. (2011) Intervening in ?-catenin signaling by sulindac inhibits S100A4-dependent colon cancer metastasis. Neoplasia, 13,131-144.

  • Sack, U, Walther, W, Scudiero, D, Selby, M, Kobelt, D, Lemm, M, Fichtner, I, & Schlag PM, Shoemaker RH, & Stein U. (2011) Novel effect of antihelminthic Niclosamide on S100A4-mediated metastatic progression in colon cancer. J Natl Cancer Inst, 103,1018-1036.

  • Pichorner, A, Sack, U, Kobelt, D, Kelch, I, Arlt, F, Smith, J, Walther, W, Schlag, PM, & Stein U. (2012) In vivo imaging of colorectal cancer growth and metastasis by targeting MACC1 with shRNA in xenografted mice. Clin Exp Metastasis, 29,573-583.

  • Dahlmann, M, Sack, U, Herrmann, P, Lemm, M, Fichtner, I, Schlag, PM, & Stein U. (2012) Systemic shRNA mediated knock down of S100A4 in colorectal cancer xenografted mice reduces metastasis formation. Oncotarget, 3,783-797.

  • Schmid, F, Burock, S, Klockmeier, K, Schlag, PM, & Stein, U. (2012) SNPs in the coding region of the metastasis-inducing gene MACC1 and clinical outcome in colorectal cancer. Mol Cancer, 11:49. [Epub ahead of print]

Complete list of publications

Selected projects

  • MACC1: a newly identified gene regulates HGF/Met signalling, is a strong biomarker for prediction of colorectal cancer metastasis, and a promising target for metastasis inhibition

  • S100A4: Inhibition of colorectal cancer metastasis by Wnt/beta-catenin-pathway-oriented small molecules targeting the metastasis progressor S100A4

Membership in scientific bodies/juries


  • German Consortium for Translational Cancer Research

  • Berlin School of Integrative Oncology

  • International PhD Program, Helmholtz Graduate School Molecular Cell Biology

  • Masters program Molecular Medicine, Charité Universitätsmedizin, Berlin

Specialist associations:

  • American Association for Cancer Research

  • European Association for Cancer Research

  • Deutsche Krebsgesellschaft (German cancer society), working group Experimental Cancer Research

  • Berliner Krebsgesellschaft (Berlin cancer society)


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