Prof. Françoise Barré-Sinoussi

Positions

• Since 2015
  Retired, Invited Scientist, Honorary President of the International Network and of the Virology Department of the Institut Pasteur
  
  

• 2005 – 2015
  Head of the “Regulation of Retroviral Infections” Unit, Institut Pasteur, Paris
  
  

• 1992 – 2004
  Head of the Retrovirus Biology Unit, Institut Pasteur, Paris, France
  
  

• 1986
  - 1991 Head of the Retrovirus Biology Laboratory, Institut Pasteur, Paris, France
  
  

• Since 1988
  Successively, Associate Professor, then Professor (since 1996) at the Institut Pasteur
  
  

• Since 1976
  Successively Assistant Professor, Associate Professor (1986) and Professor (1991) at the National Institute of Scientific and Medical Research (INSERM), France
  
  

International postgraduate experiences

• 1979
  Laboratory of Dr. R. GALLO National Cancer Institute Bethesda, NIH (USA)
  
  

• 1975 – 1976
  Postdoctoral fellows of the National Science Foundation, Laboratory of Dr. R.H. BASSIN, NIH, Bethesda (USA).
  
  

• 1973
  Laboratory of Prof. P.FISCHINGER National Cancer Institute, NIH (USA)
  
  

Education

• 1974
  Ph.D. in Virology, Institut Pasteur and University of Science, Paris 7
  
  

• 1972
  Master Degree in Biochemistry, University of Science, Paris 7
  
  

• BARRÉ-SINOUSSI F., CHERMANN J.-C., REY F., NUGEYRE M.-T., CHAMARET S., GRUEST J., DAUGUET C., AXLER-BLIN C., BRUN-VEZINET F., ROUZIOUX C., ROZENBAUM W. & MONTAGNIER L. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science, 1983, 220, 868-871.

• ALIZON M., SONIGO P., BARRÉ-SINOUSSI F., CHERMANN J.-C., TIOLLAIS P., MONTAGNIER L. & WAIN-HOBSON S. Molecular cloning of lymphadenopathy associated virus. Nature, 1984, 312, 757-760.

• BRUN-VEZINET F., ROUZIOUX C., BARRÉ-SINOUSSI F., KLATZMANN D., SAIMOT A.G., ROZENBAUM W., CHRISTOL D., GLUCKMAN J.-C., MONTAGNIER L. & CHERMANN J.-C., F. BARRE-SINOUSSI & G. PANCINO. Increased NK Cell Activity in HIV-1 Exposed but Uninfected Vietnamese Intravascular Drug users J. Immunology 2003, 171 :5663-5667

• 04 KORNFELD C, PLOQUIN MJ, PANDREA I, FAYE A, ONANGA R, APETREI C, POATY- MAVOUNGOU V, ROUQUET P, ESTAQUIER J, MORTARA L, DESOUTTER JF, BUTOR C, LE GRAND R, ROQUES P, SIMON F, BARRE-SINOUSSI F, DIOP OM, MULLER-TRUTWIN MC. Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS. J. Clin. Invest. 2005. 115 (4): 1082-1091

• SAEZ-CIRION A, LACABARATZ C, LAMBOTTE O, VERSMISSE P, URRUTIA A, BOUFASSA F, BARRE- SINOUSSI F, DELFRAISSY JF, SINET M, PANCINO G, VENET A. 2007. HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar CTL activation phenotype. PNAS, 2007 104, 6776-6781

• JACQUELIN B, MAYAU V, TARGAT B, LIOVAT AS, KUNKEL D, PETITJEAN G, DILLIES MA, ROQUES P, BUTOR C, SILVESTRI G, GIAVEDONI LD, LEBON P, BARRE-SINOUSSI F, BENECKE A, MÜLLER-TRUTWIN MC. Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response. J Clin Invest. 2009, Dec;119(12):3544-55.

• SAEZ-CIRION A, HAMIMI C, BERGAMASCHI A, DAVID A, VERSMISSE P, MELARD A, BOUFASSA F, BARRE-SINOUSSI F, LAMBOTTE O, ROUZIOUX C, PANCINO G; ANRS CO18 COHORT. Restriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllers. Blood. 2011; 118(4):955-64

• PEAN P, NERRIENET E, MADEC Y, BORAND L, LAUREILLARD D, FERNANDEZ M, MARCY O, SARIN C, PHON K, TAYLOR S, PANCINO G, BARRE-SINOUSSI F, SCOTT-ALGARA D; CAMBODIAN EARLY VERSUS LATE INTRODUCTION OF ANTIRETROVIRAL DRUGS (CAMELIA) STUDY TEAM. Natural killer cell degranulation capacity predicts early onset of the immune reconstitution inflammatory syndrome (IRIS) in HIV-infected patients with tuberculosis. Blood. 2012 Apr 5;119(14):3315-20.

• Chevalier MF, Petitjean G, Dunyach-Rémy C, Didier C, Girard PM, Manea ME, Campa P, Meyer L, Rouzioux C, Lavigne JP, BARRE-SINOUSSI F, Scott-Algara D, Weiss L. The Th17/Treg ratio, IL-1RA and sCD14 levels in primary HIV infection predict the T-cell activation set point in the absence of systemic microbial translocation. PLoS Pathog. 2013;9(6):e1003453.

• BARRE-SINOUSSI F, ROSS AL, DELFRAISSY JF. Past, present and future: 30 years of HIV research. Nat Rev Microbiol. 2013 Dec;11(12):877-83.

selected

• Member of the INSERM Governing Board, since 2016

• Honorary President of the Virology Department, Institut Pasteur, since 2015

• Member of the «AmFar HIV Cure Council», since 2014

• Member of the «UNAIDS Scientific Expert Panel», since 2014

• Member of the «Governing Board of the HIV Cure Public-Private Partnership, Initiative» on HIV Cure («Annenberg Initiative»), since 2014

• Member of the «Expert Advisory Panel on HIV» of the Bill and Melinda Gates, since 2013

• Member of the reviewing committee of the Raymond Dedonder Award, since 2012

• President of Honor of the Institut Pasteur International Network, since 2010

• Co-chair of the Ethical Committee, Institut Pasteur, 2007 – 2012

• Scientific advisor of the Institut Pasteur-TOTAL Foundation partnership, since 2005

• Member of the Board of Directors, ANRS, since 2005

• President of the International Scientific Advisory Board, ANRS, since 2003

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