Short CV/Education and training

  • 1983
    awarded Certificate of Scientific Lyceum, after 4 years of high school, by Mathematics and Physic Lyceum "I.L. Caragiale", Bucharest, Romania.

  • 1983 – 1989
    Degree in Medicine, at Faculty of Medicine and Pharmacology, University of Bucharest, Romania.

  • 1989 – 1990
    Internship in Neurology at the Department of Neurology of the "Colentina Hospital", Bucharest.

  • 1991
    Degree in Medicine and Surgery, marks 110/110 cum laude, at the University of Milan, Italy. The title of the graduation thesis was "Expression of NGF receptor in normal muscle and Duchenne dystrophy".

  • 1990 – 1991
    Research and Clinical (neurology) activity at the Department of Neurology, of "Policlinico Hospital", University of Milan, field of interest: neuroinflammation, demyelinating diseases.

  • 1991 – 1994
    Postdoctoral fellow: research activity at the Institute of General Pathology, University of Verona. The project was focused on inflammation mechanisms in brain diseases.

  • 1991 – 1995
    Residency in Neurology at the School of Neurology, Policlinico Hospital, University of Milan. Mentor: Professor Guglielmo Scarlato. The title of the specialization thesis was: "Signal transduction mechanisms controlling lymphocyte migration into the brain"

  • 1994 – 1997
    Postdoctoral fellow at the Dept. of Pathology, Stanford University School of Medicine, USA, Prof. Eugene Butcher's lab. The research studies were focused on the molecular mechanisms controlling lymphocyte migration into the inflamed brain.

  • 1999 – 2003
    PhD in Molecular and Cellular Biology and Pathology, University of Verona. Commission evaluation of the entire work: "of exceptional importance". The title of the graduation thesis was: "Molecular mechanisms controlling lymphocyte recruitment in inflamed brain venules: a critical role for P-selectin glycoprotein ligand-1"

  • 2000 – 2003
    Professor of Physiopathology, University of Verona, Italy

  • Since 2003
    Professor of General Pathology and Immunology, University of Verona, Italy

  • 2006 – 2014
    Assistant Professor of Pathology, tenure position, University of Verona, Italy

  • Since 2010
    Professor of Systems Biology, University of Verona, Course of Bioinformatics & Biotechnology

  • Since 2014
    Associate Professor of Pathology and Immunology

  • 2014
    National Qualification ("Abilitazione nazionale") for Full Professor Position ("prima fascia")

Selected publications

  • Angiari S, Donnarumma T, Rossi B, Dusi S Pietronigro E, Zenaro E, Della Bianca V, Toffali L, Piacentino G, Budui S, Rennert P, Xiao S, Laudanna C,. Casasnovas JM, Kuchroo VK, Constantin G. TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity. Immunity, Apr 17;40(4):542-53.

  • Regulatory T Cells Suppress the Late Phase of the Immune Response in Lymph Nodes through P-Selectin Glycoprotein Ligand-1. Angiari S, Rossi B, Piccio L, Zinselmeyer BH, Budui S, Zenaro E, Della Bianca V, Bach SD, Scarpini E, Bolomini-Vittori M, Piacentino G, Dusi S, Laudanna C, Cross AH, Miller MJ, Constantin G. J Immunol. 2013 Dec 1;191(11):5489-500.

  • Use of imaging to study leukocyte trafficking in the central nervous system. Zenaro E, Rossi B, Angiari S, Constantin G. Immunol Cell Biol. 2013 Apr;91(4):271-80.

  • Constantin G, Laudanna C. Transmigration of effector T lymphocytes: changing the rules. Nat Immunol. 2011 Dec 16;13(1):15-6.

  • Rossi B, Angiari S, Zenaro E, Budui SL, Constantin G. Vascular inflammation in central nervous system diseases: adhesion receptors controlling leukocyte-endothelial interactions. J Leuk Biol. 2011 Apr;89(4):539-56.

  • Constantin G and Laudanna C. A deadly migration. Immunity, 2010 Feb; 32(2): 147-149.

  • Deban L, Russo CL, Sironi M, Moalli F, Scanziani M, Zimbelli V, Cuccovillo I, Bastone A, Gobbi M, Valentino S, Doni A, Garlanda C, Danese S, Salvatori G, Sassano M, Evangelista V, Rossi B, Zenaro E, Constantin G, Laudanna C, Bottazzi B and Mantovani A. Binding to P-selectin and regulation of leukocyte recruitment by the long pentraxin PTX3, a key component of humoral innate immunity. Nat. Immunol. 2010 Apr;11(4):328-34.

  • Constantin G, Laudanna C. Leukocyte chemotaxis: from lysosomes to motility. Nat. Immunol., 2010 Jun;11(6):463-4.

  • Fabene PF, Navarro MG, Martinello M, Rossi B, Merigo F, Ottoboni L, Bach S, Angiari S, Benati D, Chakir A, Zanetti L, Schio F, Osculati A, Marzola P, Nicolato E, Homeister JW, Xia L, Lowe JB, McEver RP, Osculati F, Sbarbati A, Butcher EC, & Constantin G. A role for leukocyte-endothelial adhesion mechanisms in epilepsy. Nat Med. 2008 Dec;14(12):1377-83.

Complete list of publications

Selected projects

1. Agency: European Research Council (ERC), European Union FP7 program (Ideas).

  • Project title: Molecular mechanisms controlling leukocyte trafficking in the central nervous system

    The project is focused on the identification of new molecular mechanisms controlling the migration of leukocytes in animal models of multiple sclerosis and epilepsy by studying the interactions between leukocytes and endothelium in vivo and leukocyte trafficking inside the central nervous system parenchyma by using two-photon microscopy.

    Project duration: 1.10.2010 – 31.09.2014.

2. Agency: Ministry of Education, University and Research, Italy

  • Project title: Alpha4beta1 Antagonists for the Treatment of Epilepsy and Autoimmune Diseases

    Role in the project: project leader, co-founder of the spinoff

    The project is aimed to create a University-spinoff to synthesize and test novel small molecules able to block integrin VLA-4 for the treatment of epilepsy and autoimmune diseases.

    Project duration: 1.01.2010 – 31.12.2014.

3. Agency : National Multiple Sclerosis Society, New York, USA

  • Project title: Pantethine-based therapy in experimental autoimmune encephalomyelitis

    Role in the project: PI

    Project brief description: The project is focused on the study of clinical and neuropathological effect of metabolic intervention on experimental models of multiple sclerosis.

    Project duration: 1.10.2012 – 30.09.2014.

Membership in scientific bodies/juries

  • Member of the Scientific Board of Fondazione Italiana Sclerosi, Multipla (FISM) for grant evaluation, since 2011

  • Member of the H. Kunkel Society, New York, USA, since 2006

  • Member of the Directive Council of the Italian Association of Neuroimmunology (AINI), 2006 – 2009

  • Member of the American Association of Immunologists (AAI), USA, since 2002

  • Member of the Italian Society of Immunology, since 2001

Additional qualifications

  • Co-founder of Veneto Pharma, an university spinoff aimed to identify new therapeutic approaches based on inhibition of VLA-4 integrin.

  • Co-founder of Leuvas therapeutics, Mountain View, CA, USA, an SME aiming to develop new therapies for inflammatory diseases.

Soft Skills/Other activities and achievements

Other activities and achievements/family

  • Interest in classical music, martial arts, hiking.


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