Short CV/Education and training

  • 2010
    Strategic Professorship in Cell and Tumor Biology from Karolinska Institutet

  • 2003
    Senior Researcher Position in Clinical Molecular Biology from Swedish Research Council, MTC, KI

  • 2002
    Associate Professor (Docent), Karolinska Institutet

  • 2001
    Group leader, Dept. of Oncology-Pathology, Cancer Center Karolinska (CCK), Karolinska Institutet

  • 1997
    4-year Assistant Professor position from Karolinska FoN

  • 1995 – 1996
    Swedish Cancer Society Guest Researcher Fellowship

  • 1993 – 1994
    The Wenner-Gren Foundation Postdoc Fellowship

  • 1993
    KI Postdoc Fellowship (declined)

  • 1992 – 1997
    Postdoctoral Fellow, Department of Tumor Biology and Microbiology and Tumor Biology Center (MTC), Karolinska Institutet, Stockholm, Sweden (laboratory of Klas G. Wiman)

  • 1991
    PhD, Institute of Genetics, Moscow, Russia.

Selected publications

  • Grinkevich V, Nikulenkov F, Shi Y, Enge M, Bao W, Maljukova A, Gluch A, Kel A, Sangfelt O, and Selivanova G. Ablation of key oncogenic pathways by RITA-reactivated p53 is required for efficient apoptosis. (2009) Cancer Cell, 15(5):441-53

  • Enge M, Bao W, Hedström E, Jackson SP, Moumen A, and Selivanova G. MDM2-dependent downregulation of p21 and hnRNPK provides a switch between apoptosis and growth arrest induced by pharmacologically reactivated p53 (2009). Cancer Cell, 3;15(3):171-83.

  • Issaeva, N., Bozko, P., Enge, M., Protopopova, M., Verhoef, L. G.G.C., Masucci, M., Pramanik, A., and Selivanova, G. (2004). Small molecule RITA binds to p53, blocks p53/HDM-2 interaction and activates p53 function in tumors. Nat Med., 10 (12), 3121-1328.

  • Bykov, V., Issaeva, N., Shilov, A., Hultcrantz M., Pugacheva, E., Chumakov, P., Bergman, J., Wiman, K.G., and Selivanova, G. (2002) Restoration of the tumor suppressor function of mutant p53 by a small molecule, Nat. Med., 8 (3), 282-288.

  • Selivanova, G., Iotsova, V., Okan I., Fritsche M., Ström, M., Grafsröm, R., and Wiman, K. G. (1997) Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain. Nat. Med. 3, 632-638.

  • Li H, Zhang Y, Ströse A, Tedesco D, Gurova K, Selivanova G. Integrated high- throughput analysis identifies Sp1 as a crucial determinant of p53-mediated apoptosis. Cell Death Differ. 2014, Sep;21(9):1493-502, Epub 2014 Jun 27.

    7. Shi Y., Nikulenkov F., Zawacka-Pankau J., Li H., Gabdoulline R., Xu J., Eriksson S., Hedström E., Issaeva N., Kel A., Arnér E., and Selivanova G. ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis. Cell Death Diff, 2014, 21:4; 612-23 This paper has been awarded a prize of 20 000 Euro by German Cancer Aid (Stiftung Für Die Erforschung ung Bekämpfung der Krebsklarnkheiten)

  • Burmakin M, Shi Y, Hedström E, Kogner P, Selivanova G. Dual targeting of wild-type and mutant p53 by small molecule RITA results in the inhibition of N-Myc and key survival oncogenes and kills neuroblastoma cells in vivo and in vitro. Clin Cancer Res. 2013 Sep 15;19(18):5092-103. doi: 10.1158/1078-0432.CCR-12-2211. Epub 2013 Jul 17.

  • Nikulenkov F, Spinnler C, Li H, Tonelli C, Shi Y, Turunen M, Kivioja T, Ignatiev I, Kel A, Taipale J, Selivanova G. Insights into p53 transcriptional function via genome-wide chtromatin occupancy and gene expression analysis. (2012) Cell Death Differ. Dec;19(12):1992-2002. This article has been recommended as being of special significance in its field by the F1000 Faculty: http://f1000.com/717959613.

  • Zawacka-Pankau J, Grinkevich VV, Hunten S, Nikulenkov F, Gluch A, Li H, Enge M, Kel A, Selivanova G. Inhibition of glycolytic enzymes mediated by pharmacologically activated p53: targeting Warburg effect to fight cancer. J Biol Chem. 2011 Dec 2;286(48):41600-15.



Complete list of publications

Selected projects

  • Reactivation of mutant p53 by a synthetic peptide

  • Restoration of the tumor suppression function of mutant by a small molecule: from lab bench to clinic Exploring p53 regulation and p53 transcription function: friends and foes

Membership in scientific bodies/juries

Member of the Grant Evaluation Boards of

  • Swedish Research Council, Medicine, 2006 – 2010

  • Swedish Cancer Society, since 2013

  • Norwegian Research Council, PANELFYS-2, 2011 – 2014

  • French National Cancer Institute, 2009 – 2015

  • Karolinska Institute, 2009 – 2011

  • Robert Lundeberg’s Foundation, 2008

  • Alex and Eva Wallström foundation, 2012 – 2016

  • Postgraduate education at KI, 2010 – 2012

  • Ragnar Söderberg Foundation, 2015 – 2016

  • Norwegian Cancer Society, since 2017

Reviews of grant applications for

  • Cancer Research UK, Medical Research Council (UK)

  • Italian Ministry for Education

  • University and Research

  • Italian National Cancer Institute “Regina Elena”

  • Italian Foundation for Cancer Research

  • Dutch Cancer Society

  • Association for International Cancer Research (AICR)

  • Israeli Ministry of Science and United States/Israel Binational Science Foundation

  • The Fund for Scientific Research-FNRS (Belgium)

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