Short CV/Education and training

  • 1984
    PhD at the MRC Laboratory of Molecular Biology, studying affinity maturation of the immune response with Cesar Milstein.

  • 1985 – 1990
    Post-doctoral fellowship with Irv Weissman at Stanford.

  • 1990 – 1995
    Scientific Member, Basel Institute for Immunology, Switzerland.

  • 1995 – 1997
    Wellcome Trust Senior Fellow, MRC Laboratory for Molecular Cell Biology, University College London

  • 1997 – 2007
    Wellcome Trust Senior Fellow, Sir William Dunn School of Pathology, University of Oxford

  • 2007 – 2008
    Professor of Immunology and Cell Biology Wellcome Trust Principal Research Fellow, Cambridge Institute for Medical Research (CIMR).

  • Since 2012
    Director of CIMR.

Selected publications

Significant Publications:

  • de la Roche M, Ritter AT, Angus KL, Dinsmore C, Earnshaw CH, Reiter JF, Griffiths GM.

    Hedgehog signaling controls T-cell killing at the immunological synapse. Science. 2013 in press, Dec 6th. DOI: 10.1126/science.1244689

  • Hackmann Y, Graham SC, Ehl S, Höning S, Lehmberg K, Aricò M, Owen DJ, Griffiths GM.

    Syntaxin binding mechanism and disease-causing mutations in Munc18-2. Proc Nat Acad Sci (USA) 2013, 110(47):E4482-91. PMID: 24194549

  • Stinchcombe JC, Salio M, Cerundolo V, Pende D, Arico M, Griffiths GM. Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems. BMC Biol. 2011 9:45. PMCID: PMC3149597

  • Tsun A, Qureshi I, Stinchcombe JC, Jenkins MR, de la Roche M, Kleczkowska J, Zamoyska R, Griffiths GM. Centrosome docking at the immunological synapse is controlled by Lck signaling. J Cell Biol. 2011 192(4): 663-74. PMCID: PMC3044125

  • Griffiths GM, Tsun A, Stinchcombe JC. The immunological synapse: a focal point for endocytosis and exocytosis. J Cell Biol. 2010, 189(3): 399-406. Review. PMCID: PMC2867296

  • Jenkins MR, Tsun A, Stinchcombe JC, Griffiths GM. The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse.

    Immunity. 2009 31(4):621-31. PMCID: PMC2791175.

  • Stinchcombe JC, Majorovits E, Bossi G, Fuller S, Griffiths GM. Centrosome polarisation delivers secretory granules to the immunological synapse. Nature. 2006 443(7110): 462-65. Erratum in: Nature. 2006 9;444(7116):236. PMID:17006514 (Trust)

  • Stinchcombe JC, Bossi G, Booth S, Griffiths GM. The immunological synapse of CTL contains a secretory domain and membrane bridges. Immunity. 2001 15(5):751-61. PMID: 11728337

  • Uellner R, Zvelebil MJ, Hopkins J, Jones J, McDougall LK, Morgan BP, Podack E,

    Waterfield, MD, Griffiths GM. Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain. EMBO J. 1997 16(24) 7287-96. PMCID: PMC1170329 (Trust)

  • Griffiths GM, Isaaz S. Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor. J Cell Biol. 1993120(4): 885-96. PMCID: PMC2200067

Membership in scientific bodies/juries

  • Wellcome Trust Basic Science Interview Committee

  • Wellcome Trust Sir Henry Wellcome Postdoctoral Fellowship Committee

  • EMBO Membership Committee


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