Prof. Avan Aihie Sayer
HealthAcademic Medicine
Prof. Helen Arthur
Nominated by
- The Wellcome Trust
- AcademiaNet member since 09.12.2013
- AcademiaNet- Selection Criteria
Employed by
- Newcastle University
Academic Discipline/Fields
- Health and welfare
Field
Health
Area of specialisation
Role of TGFbeta signalling in cardiovascular development and heart repair
Research interests
Role of endoglin in cardiovascular development and disease.
How endoglin modulates angiogenesis in coronary vessel development and in heart repair.
How TGFbeta signalling regulates angiogenesis.
Characterising molecular and cellular defects in Hereditary Haemorrhagic Telangiectasia to inform development of patient therapies.
Interested in
- Membership in scientific bodies
Languages
English
Doctorate
- 1980: molecular Genetics
Short CV/Education and training
- 1976BSc 1st class honours, Genetics University of Liverpool
- 1980PhD Molecular Genetics, University of Nottingham
Employment at Newcastle University in the following posts:
- 1980 – 1983Demonstrator, Department of Biochemistry.
- 1983 – 1984Lecturer, Department of Biochemistry and Genetics. Employment contract from 1983 to 1988, but resigned when my first child was born to enable me to work part-time.
- 1984 – 1986MRC Postdoctoral Research Associate (half-time), Department of Biochemistry and Genetics.
- 1986 – 1995Career break to care for my young family.
- 1996 – 1997Postdoctoral Research Associate, Department of Human Genetics.
- 1998 – 2002Wellcome Trust Career Re-entry Research Fellow, School of Biochemistry and Genetics.
- 2002 – 2003Senior Research Associate, Institute of Human Genetics
- 2003 – 2008British Heart Foundation Jacob Walton Johnson Lecturer, Institute of Human Genetics.
- 2008 – 2013British Heart Foundation senior research fellow
Selected publications
X. Wang, S. Abraham, JAG McKenzie, N Jeffs, M Swire, V Tripathi, UFO Luhmann, CAK Lange, Z Zhai, HM Arthur, J Bainbridge, SE Moss & J Greenwood (2013) Lrg1 promotes angiogenesis by modulating endothelial TGFß signaling Nature 499(7458):306-11.
Anderberg C, Cunha S , Zhai Z , Pardali E, Cortez E, Johnson J, Franco M, Paez-Ribes M, Cordiner R, Fuxe J, Goumans MJ, Casanovas O, ten Dijke , Arthur HM, Pietras K (2013) Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination. J Exp Med. 210(3):563-79.
Mahmoud M, Allinson KR, Zhai Z, Oakenfull R, Adams RH, Ghandi P, Fruttiger M and Arthur HM. (2010) Pathogenesis of arteriovenous malformations in the absence of endoglin. Circulation Research, 106(8):1425-33.
Complete list of publications
Selected projects
Led my Institute's Athena Swan application- aims to support female academic career development.
Membership in scientific bodies/juries
Member of Heart Research UK medical review panel 2007-2013
Member of BHF project grant review panel 2011-2014
Media coverage
British Heart Foundation fight for every heart beat, TV advert and media campaign
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News
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Uncovering the Secret of Blood Vessel Growth
Helen Arthur's research examines how genetic faults in blood vessel growth cause human diseases and how these pathways can also be harnessed to treat people who have had a heart attack.