Dr. Irene Agyepong
Health, Public Health
Health
Stem Cells and Skeletal Ageing
Animal welfare and 3Rs, drug development, tissue engineering, bone analysis
Senate award for excellence in learning and teaching, University of Sheffield, 2011
Sheffield Deputy Director of the MRC Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing, (since 2012)
Chair of Early Career Group (2009-2012), providing strategic direction for training and career development of early career researchers. the programme was shortlisted for The Times Higher Education Award for Excellent Support of Early Career Researchers
English, Italian
ST Mohanty, CJ Cairney, AD Chantry, S Madan, J Fernandes, SJ Howe, HD Moore, MJ Thompson, B Chen, A Thrasher, WN Keith, I Bellantuono A small molecule modulator of prion protein increases human mesenchymal stem cell lifespan, ex vivo expansion and engraftment to bone marrow in NOD/SCID mice, Stem Cells 30(6):1134-43, 2012
A Gambardella, C.K. Nagaraju, P.J. O?Shea, S.T. Mohanty, L. Kottam, J. Pilling M. Sullivan, M. Djerbi , W. Koopmann, P.I.Croucher and I Bellantuono. Glycogen synthase kinase-3alpha/beta inhibition promotes in vivo amplification of endogenous mesenchymal progenitors with osteogenic and adipogenic potential and their differentiation to the osteogenic lineage JBMR 26(4):811-21, 2011
I Bellantuono*, Aldahmash A and Kassem M*: Aging of marrow stromal stem cells and their contribution to age related bone loss. BBA 1792(4):364-70
RF Wynn, CA Hart, LO?Neill, JE Wraith, LJ Fairbairn and I Bellantuono. A small proportion of Mesenchymal stem cells strongly express functionally active CXCR4 receptor capable of promoting migration to bone marrow, Blood 104: 2643-5, 2004
M A Baxter, R F Wynn, S N Jowitt, J E Wraith, L J Fairbairn, and I Bellantuono. Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion StemCells, 22, 675-682, 2004
I.Bellantuono, L.Gao, S. Parry, S. Marley, F.Dazzi, J.M. Goldman, and H.J. Stauss Two distinct HLA-A0201-presented epitopes of the Wilms Tumour Antigen 1 can function as targets for leukaemia-reactive CTL. Blood 100 3835-3837, 2002
Identification of drugs which delay stem cell ageing
Computational models of bone formation and resorption to predict changes in bone in preclinical studies
The role of the bone microenvironment in the development of Myelodysplastic Syndromes
Stem cells and cell senescence
Deputy Chair of the Bioscience Skills and Career Strategy panel, Biotechnology and Biological Sciences Research Councils (since 2013)
Member of the NC3R Aged Rodent Group (since 2013)
New scientist August 2012: http://www.newscientist.com/article/mg21528784.600-protecting-prion-protein-keeps-stem-cells-young.html#.VFoJwE1ybIU
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Health, Public Health
Agriculture, Health, Food Safety
Biological and related sciences, Health, Neurophysiology (synaptic physiology)
Biological and related sciences, Health, Cell Biology, Cellular signaling, Cancer biology, Cancer therapy