Short CV/Education and training

  • 1948
    Born in Helsinki, Finland

  • 1972
    Dental School (DDS), Medical Faculty, Univ Helsinki

  • 1975
    Doctor of Odontology (Dr. Odont. , PhD), Univ Helsinki

  • 1978 – 1980
    Visiting Associate (postdoc), Lab Developmental Biology and Anomalies, NIH, NIDR, Bethesda, MD, USA

  • 1980
    Docent in Developmental Biology, Univ. Helsinki

  • 1990 – 2001
    Professor and Chairman, Department of Pedodontics and Orthodontics, Univ Helsinki

  • Since 1996
    Professor, Research Director of Developmental Biology Program, Institute of Biotechnology, Univ Helsinki

Selected publications

  • Vainio, S., et al. Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell 75: 45-58, 1993.

  • Wang, X-P., et al. Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation. Dev Cell 7: 719, 2004.

  • Järvinen, E., et al. Continuous tooth generation in mouse is induced by activated epithelial Wnt/ ßcatenin signaling. Proc. Natl. Acad. Sci USA 103: 18627, 2006.

  • Wang, X-P., et al., An integrated gene regulatory network controls epithelial stem cell proliferation in teeth. PLoS Biol 5: 1324-1333, 2007.

  • Närhi, K., et al. Sustained epithelial {beta}-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation. Development 135:1019-1028, 2008.

  • Nieminen P, et al. Inactivation of IL11 signaling causes craniosynostosis, delayed tooth eruption and supernumerary teeth. Am J Hum Genet. 89: 67-81, 2011.

  • Juuri E, et al., Sox2+ Stem Cells Contribute to All Epithelial Lineages of the Tooth via Sfrp5+ Progenitors. Dev. Cell 23: 317-328, 2012.

  • Juuri E, Jussila M, Seidel K, Holmes S, Wu P, Richman J, Heikinheimo K, Chuong CM, Arnold K, Hochedlinger K, Klein O, Michon F, Thesleff I. Sox2 marks epithelial competence to generate teeth in mammals and reptiles. Development 140:1424-1432, 2013.

  • Thesleff, I, Tummers, M., Tooth organogenesis and regeneration. In: Stembook, doi/10.3824/stembook.1.37.1,

  • 105. Jussila, M., Thesleff, I. Signaling networks regulating tooth organogenesis and regeneration, and the specification of dental mesenchymal and epithelial cell lineages. Cold Spring Harb Perspect Biol. 2012 Apr 1;4(4):a008425. doi: 10.1101/cshperspect.a008425. Review.

Selected projects

  • Regulation of ectodermal organ development

  • Regulation of tooth development

  • Regulation of craniofacial bone formation

  • Stem and progenitor cells in teeth

  • Genetic causes of tooth agenesis

  • Pathogenesis of ectodermal dysplasia

Membership in scientific bodies/juries

  • Institute of Medicine (IOM) of the National Academies, USA

  • AAAS Fellow, USA

  • European Molecular Biology Organization

  • International Association of Dental Research

  • European Orthodontic Society

  • Finnish Society of Developmental Biology

Additional qualifications

  • Specialist´s rights in Orthodontics, 1983

Soft Skills/Other activities and achievements

Other activities and achievements/family

  • Mother of 3 adult children, 6 grandchildren


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