Prof. Dr. Seema Agarwal
Physical sciences, Preparative and physical chemistry of polymersNanotechnology
Wellcome Trust Research Fellow
Biological and related sciences, Physical sciences
Proteins and Biochemistry, Structural Biology and Biophysics
Protein folding, misfolding and assembly
Fellow of Royal Society
Fellow of National Academy of Medical Sciences
Member of EMBO
Royal Society of Chemistry Interdisciplinary Prize 2013
Cynthia Chan Memorial Lecturer 2013 UC Berkeley
US Genomics Award for Outstanding Investigator in the Field of Single Molecule Biology – Biophysical Society 2010
English
J. Mol. Bio., 2015, 427, 2159-2165
Nat. Commun., 2015, 6, 7271
Science, 2014, 346, 6216
Proc. Natl. Acad. Sci. USA, 2014, 111, 15420–15425
Proc. Natl. Acad. Sci. USA, 2014, 111, 12055-12060
J. Am. Chem. Soc., 2014, 136, 5197
J. Mol. Biol., 2014, 426, 1600
Nature, 2013, 502(7473), 6323
J. Mol. Biol., 2014, 426, 21
J. Phys. Chem. B, 2013, 117, 13346
Multidisciplinary studies of protein folding, misfolding and assembly
Fundamental Questions:
(1) How do proteins fold at the atomistic level and how is misfolding avoided?
(2) How do changes in sequence, as the result of evolution, or brought about by mutation affect
the biophysical properties of proteins?
We study families of proteins using a multidisciplinary approach, to address specific questions:
(i) What is the relative importance of topology, chain connectivity, secondary structure content and sequence in the folding of small model proteins?
(ii) How do larger, multidomain proteins fold and, importantly, avoid misfolding?
(iii) By what mechanisms do intrinsically disordered proteins concomitantly fold and bind to their targets?
Fellow of Royal Society of Chemistry
Member of Protein Society
Member of Biophysical Society
Member of American Chemical Society
Member of the International Advisory Board for ChELSI (Chemical Engineering at the Life Sciences Interface), University of Sheffield
Member of the Wellcome Trust Peer Review College
Member of Wellcome Trust/NIH Studentship Panel
Member of Scientific Advisory Board of Astbury Centre Wellcome Trust PhD programme (University of Leeds)
Mentoring
Career Development
Leadership Training
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Physical sciences, Preparative and physical chemistry of polymersNanotechnology
Physical sciences, Quantum simulation, Ultracold atoms
Biological and related sciences, Environment, Plant Ecology, Conservation Biology, Landscape Genomics
Physical sciences, Asteroseismology