Short CV/Education and training

  • 1995
    MSc, Biochemistry, University of Turku, Finland

  • 1995 – 2000
    PhD student, University of Turku

  • 2000 – 2003
    Post-doctoral fellow, Prof. Peter J. Parker's laboratory, Cancer Research UK, London

  • 2001 – 2003
    EMBO long-term fellowship

  • 2003 – 2007
    Academy of Finland Principal Investigator, Cell Adhesion and Cancer Laboratory, VTT Medical Biotechnology

  • 2004
    Adjunct professor, Biochemistry, University of Turku

  • Since 2008
    Professor of Molecular Cell Biology, Cell Adhesion and Cancer Laboratory, VTT Medical Biotechnology and University of Turku

Selected publications

  • Ivaska, J., Reunanen, H., Westermarck, J., Kähäri, V-M., and Heino, J. (1999) Integrin ?2?1 cytoplasmic tail mediates isoform specific activation of p38 and upregulation of collagen gene transcription by a mechanism involving the? ?2 cytoplasmic tail. J. Cell Biol. 147:401-415

  • Ivaska J., Bosca, L and Parker PJ. (2003) PKC? is a permissive link in integrin-dependent IFN? signaling facilitating JAK activation of STAT1 . Nat. Cell Biol. 5(4):363-9.

  • Mattila E., Pellinen, T., Nevo, J., Vuoriluoto, K. Arjonen, A. and Ivaska, J (2005) Negative regulation of EGFR signalling via integrin ?1?1-mediated activation of protein tyrosine phosphatase TCPTP. Nature Cell Biol. 7:78-85.

    Pellinen T, Arjonen A, Vuoriluoto K, Kallio K, Fransen JA, Ivaska J. (2006) Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins. J. Cell Biol. 173:767-80.

  • Pellinen T., Tuomi, S., Arjonen, A., Wolf, M., Edgren, H., Meyer, H., Grosse, R., Kitzing, T., Rantala, JK., Kallioniemi O., Fässler, R., Kallio, M., and Ivaska, J. (2008) Integrin traffic regulated by Rab21 is necessary for cytokinesis. Dev. Cell, 15:371-385.

  • Tuomi, S., Mai, A., Nevo, J., Laine, JO, Vilkki, V., Öhman, TJ., Gahmberg, CG., Parker, PJ. and Ivaska, J. (2009) PKC? Regulation of an ?5 Integrin?ZO-1 Complex Controls Lamellae Formation in Migrating Cancer Cells. Science Signaling, 2 (77): ra32

  • Vuoriluoto, K., Haugen, H., Kiviluoto, S., Mpindi, J-P, Nevo, J., Gjerdrum, C., Lorens, J.B. and Ivaska, J. (2011) Vimentin regulates EMT induction and migration by governing Axl expression in breast cancer. Oncogene. 30:1436-1448.

    Mai, A., Veltel, S., Pellinen, T., Padzik, A., Coffey, E., Marjomäki, V. and Ivaska, J. (2011) Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor trafficking in migrating cancer cells. J. Cell Biol. 194:291-306.

  • Rantala, J.K., Pouwels, J., Pellinen, T., Veltel, S., Laasola, P., Potter, C., Duffy, T., Sundberg, J.P., Askari, J.A.-. Humphries, M., Kallioniemi, O., Parsons, M., Salmi, M. and Ivaska, J. (2011) Sharpin is an endogenous inhibitor of beta1-integrin activation. Nat. Cell Biol. 13:1315-1324.

Selected projects

  • ERC Cancer signalosomes 2008 – 2013

Membership in scientific bodies/juries

Editorial Board Member:

  • Cell Reports, since 2011; Small GTPases, since 2010; Critical reviews in Oncogenesis, 2006 – 2008

Peer-review work:

  • Nature Reviews Cell Biology, Nature Cell Biology, PNAS, Trends in Cell Biology, Developmental Cell, Current Biology, Molecular and Cellular Biology, Journal of Cell Biology, Journal of Cell Science, Molecular Biology of the Cell, Traffic, Cancer Research, International Journal of Cancer, European Journal of Immunology, Experimental Cell Research, FEBS letters, Molecular Cancer, Plos One, Biological Procedures Online

Reviews for grant and fellowship applications:

  • Cancer Research UK; Norwegian Forskningsrådet; Breast Cancer Campaign, UK; Welcome Trust, UK; Health Research Board, Ireland; EMBO fellowships; MRC grants, UK; AICR grants, UK; IFCC grants, Italy; AICR grants, Italy

Soft Skills/Other activities and achievements

Soft Skills

  • Mother of two


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