Short CV/Education and training

  • Prof. Avraham is Full Professor at the Department of Human Molecular Genetics and Biochemistry and Vice Dean at the Sackler Faculty of Medicine, Tel Aviv University. Born in Canada and raised in the US, Prof. Avraham received her B.A. degree from Washington University in St. Louis, Missouri and then went on to perform her Ph.D. at the Weizmann Institute of Science in Rehovot, Israel. Her doctoral thesis focused on the development of a model for Down syndrome. She performed her postdoctoral training at the National Cancer Institute in Frederick, Maryland, USA in mammalian genetics.

  • Since joining the faculty at Tel Aviv University in 1996, Prof. Avraham’s work has centered on the discovery of disease genes, focusing on hereditary hearing loss. Her team uses a multidisciplinary approach, using genetic, developmental, biochemical, cellular and bioinformatic tools to decipher the molecular basis of hearing loss. Dr. Avraham is leading the field in elucidating mechanisms by which mutations lead to auditory and vestibular dysfunction, using state-of-the-art technology. The tools acquired in studying the genes involved in deafness, and deciphering their regulation, are now being used in the Avraham laboratory for the development of therapeutic techniques for the treatment of hearing impairment.

Selected publications

  • Ushakov, K., Koffler-Brill, T., Rom, A., Perl, K., Ulitsky, I., Avraham, K.B. Genome-wide identification and expression profiling of long non-coding RNAs in auditory and vestibular systems. Sci. Rep., 7:8637.

  • Bhonker, Y, Abu-Rayyan, A, Ushakov, U, Amir-Zilberstein, A, Shivatzki, S, Yizhar-Barnea, O, Elkan-Miller, T, Tayeb-Fligelman, E, Kim, S.M., Landau, M., Kanaan, M., Chen, P., Matsuzaki, F., Sprinzak, D. and Avraham, K.B. (2015) The GPSM2/LGN GoLoco motifs are essential for hearing. Mamm. Genome, 27:29-46.

  • Rudnicki, A.*, Isakov, O.*, Ushakov, K., Shivatzki, S., Weiss, I., Friedman, L.M., Shomron, N. and Avraham, K.B. (2014) Next-generation sequencing of small RNAs from inner ear sensory epithelium identifies microRNAs and defines regulatory pathways. BMC Genomics. 15:484.

  • Rudnicki, A., Shivatzki, S., Beyer, L.A., Takada, Y., Raphael, Y. and Avraham, K.B. (2014) microRNA-224 regulates Pentraxin 3, a component of the humoral arm of innate immunity, in inner ear inflammation. Hum. Molec. Genet. 23:3138-46.

  • Horn, H.F.*, Brownstein, Z.*, Lenz, D.R., Shivatzki, S., Dror, A.A., Dagan-Rosenfeld, O., Friedman, L.M., Roux, K.J., Kozlov, S., Jeang, K.-T., Frydman, M., Burke, B., Stewart, C.L., and Avraham, K.B. (2013) The LINC complex is essential for hearing. J. Clin. Invest. 123:740-750.

  • Brownstein, Z., Friedman, L.M., Shahin, H., Oron-Karni, V., Kol, N., Abu Rayyan, A., Parzefall, T., Lev, D., Shalev, S., Frydman, M., Davidov, B., Shohat, M., Rahile, M., Lieberman, S., Levy-Lahad, E., Lee, M., Shomron, N., King, M.-C., Walsh, T., Kanaan, M. and Avraham, K.B. (2011) Targeted genomic capture and massively parallel sequencing to identify genes for hereditary hearing loss in Middle Eastern families. Genome Biol. 12: R89.

  • Elkan-Miller, T., Ulitsky, I., Hertzano, R., Rudnicki, A., Dror, A.A., Lenz, D.R., Elkon, R., Irmler, M., Beckers, J., Shamir, R. and Avraham, K.B. (2011) Integration of transcriptomics, proteomics, and microRNA analyses reveals novel microRNA regulation of targets in the mammalian inner ear. PLoS One 6: e18195.

  • Dror, A.A., Politi, Y., Shahin, H., Lenz, D.R., Dossena, S., Nofziger, C., Fuchs, H., Hrabé de Angelis, M., Paulmichl, M., Weiner, S. and Avraham, K.B. (2010). Calcium oxalate stone formation in the inner ear as a result of an Slc26a4 mutation. J. Biol. Chem. 285: 21724-21735.

  • Walsh, T., Pierce, S.B., Lenz, D.R., Brownstein, Z., Dagan-Rosenfeld, O., Shahin, H., Roeb, W., McCarthy, S., Nord, A.S., Gordon, C.R., Ben-Neriah, Z., Sebat, J., Kanaan, M., Lee, M.K., Frydman, M., King, M.-C. and Avraham, K.B. (2010) Genomic duplication and over-expression of TJP2/ZO-2 leads to altered expression of apoptosis genes in progressive non-syndromic hearing loss DFNA51. Am. J. Hum. Genet. 87: 101-109.

  • Friedman, L.M., Dror, A.A., Mor, E., Tenne, T., Toren, G., Satoh, T., Biesemeier, D.J., Shomron, N., Fekete, D.M., Hornstein, E. and Avraham, K.B. (2009) MicroRNAs are essential for development and function of inner ear hair cells in vertebrates. Proc. Natl. Acad. Sci. USA, 106: 7915-7920.

Complete list of publications

Membership in scientific bodies/juries

  • European Molecular Biology Organization (EMBO)

  • Association for Research in Otolaryngology (ARO)

  • Human Genome Organization (HUGO), Council member

  • Collegium Oto-Rhino-Laryngologicum Amicitiae Sacrum (CORLAS)


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