Prof. Lene Broeng Oddershede

EDUCATION

• 1998
  PhD in experimental physics, University of Southern Denmark
  
  

• 1995
  Cand. Scient., specialization in mathematics and physics, University of Southern Denmark
  
  

• 1992
  Bachelor of Science, specialization in mathematics and physics, University of Southern Denmark
  
  

EMPLOYMENTS

• Since 2015
  Center leader for StemPhys, a Danish National Research Foundation Center of Excellence, Denmark
  
  

• Since 2015
  Professor at the Niels Bohr Institute (NBI), Denmark
  
  

• Since 2003
  Group Leader for the Optical Tweezers Group ( ~15 people), NBI, Denmark
  
  

• 2003 – 2014
  Tenured associate professor at the NBI, Denmark
  
  

• 1998 – 2003
  Assistant professor at NBI, in experimental biological physics. Responsible for constructing the optical tweezers laboratory, this was the first optical trapping facility in Scandinavia, Denmark
  
  

• 1996 – 1997
  Visiting graduate student at the James Frank Institute, University of Chicago, in the group of Professor Sidney R. Nagel, USA
  
  

GRANTS

• 2015 – 2021
  Danmarks Grundforskning Center of Excellence ‘StemPhys: Stem Cell Decision making’, 60 mio Dkr, PI: LBO
  
  

• 2015 – 2018
  Novo Nordisk Foundation Synergy Grant ‘LANTERN: Laser activated nanoparticles for tumor elimination’, 14.5 mio Dkr, PI: LBO
  
  

• 2014 – 2017
  FNU Research Project 2 ‘Force mapping during cancer cell division and invasion’, 6 mio Dkr, PI: LBO
  
  

• 2012 – 2014
  Lundbeckfonden Center for active nanoparticles, 2.5 mio Dkr, PI: LBO
  
  

• 2010 – 2013
  Lundbeckfonden Center for complexity of amyloid formation, 5 mio Dkr, PI: M. Høgh Jensen, LBO one of 3 co-applicants
  
  

• 2010 – 2015
  Lundbeckfonden Center for biomembranes in nanomedicine, 36 mio Dkr, PIs: D. Stamou and U. Gether, LBO one of 7 co-applicants
  
  

• 2009
  FNU Equipment, Danish research councils, 1.2 mio Dkr, PI: LBO
  
  

• 2008
  - 2013 Excellence Center at University of Copenhagen, 20 mio Dkr, PI: LBO
  
  

• 2004
  - 2009 BioNET a Villum Kann Rasmussen Center, 25 mio Dkr, PI: M. Høgh Jensen, LBO one of 9 co-applicants
  
  

• 2006
  - 2008 FNU Rammebevilling Danish Research Councils, 600.000 Dkr, PI: LBO
  
  

• 2006
  Carlsbergfoundation, Equipment 1 mio Dkr, PI: LBO
  
  

• 1999
  - 2004 FREJA grant Danish Research Councils, 6 mio Dkr, PI K. Berg-Sørensen, LBO co-applicant
  
  

• 1995
  - 1998 PhD fellowship from Danish Research Councils, applicant: LBO
  
  

• N.S. Rossen, J.M. Tarp, J. Mathiesen, M.H. Jensen, L.B. Oddershede. Long-range ordered vorticity patterns patterns in living tissue induced by cell division. Nature Communications, vol. 5 p. 5720 (1-7) (2014).

• K. Norregaard, M. Andersson, P.E. Nielsen, S. Brown, L.B. Oddershede. Tethered particle analysis of supercoiled circular DNA using PNA handles. Nature Protocols, vol. 9 p. 2206 (2014).

• H. Ma, P. Tian, J. Pello, P.M. Bendix, L.B. Oddershede. Heat generation by irradiated complex composite nanostructures. Nano Letters, vol. 14 p.612-619 (2014).

• K. Norregaard, M. Andersson, K. Sneppen, P.E. Nielsen, S. Brown, L.B. Oddershede. DNA supercoiling enhances cooperativity and efficiency of an epigenetic switch. PNAS, vol. 110 p.17386-17391 (2013).This paper prompted an invitation for an Addendum in Bacteriophage 2014.

• T. Jakociunas, M.D. Jordo, M.A. Mebarek, C.M. Bunner, J. Verhain-Hansen, L.B. Oddershede, G. Thon, Subnuclear relocalization and silencing of a chromosomal region by an ectopic rDNA repeat, PNAS, vol. 110 p.E4465-E4473 (2013).

  Rated as 'of outstanding interest' in Curr Opinion in Cell Bio. vol. 28 p. 54 (2014).

• H. Ma, P.M. Bendix, L.B. Oddershede. Large-Scale Orientation Dependent Heating from a Single Irradiated Gold Nanorod. Nano Letters vol.12 p.3954-3960 (2012).

• L.B. Oddershede. Force probing of individual molecules inside the living cell is now a reality. Nature Chemical Biology, vol 8 p.879-886 (2012).

• P. Gross, N. Laurens, L.B. Oddershede, U. Bockelmann, E.J.G. Peterman, G.J.L. Wuite. Quantifying how DNA stretches, melts and changes twist under tension, Nature Physics vol. 7 p.731-736 (2011).

• A. Kyrsting, P.M. Bendix, D.G. Stamou, and L.B. Oddershede. Heat Profiling of Three-Dimensionally Optically Trapped Gold Nanoparticles using Vesicle Cargo Release. Nano Letters, vol 11 p.888-892 (2011).

• J.H. Jeon, V. Tejedor, S. Burov, E. Barkai, C. Selhuber, K. Berg-Sørensen, L. Oddershede, R. Metzler. In vivo anomalous diffusion and weak ergodicity breaking of lipid granules. Physical Review Letters, vol. 106 p.048103 (2011). This paper received the CeNS award for an outstanding publication.

• Stem cell decision making

• Development of a plasmon based cancer therapy

• Force mapping during cancer cell division and migration

• Member of the Royal Danish Academy of Sciences and Letters, since 2014

• Danish member of ERC COST action no 1205 (optics and microfluidics), 2012 – 2016

• Danish National Committee for Biophysics, since 2007

• NBI Visionary and Strategic Committee, 2003 and 2008 – 2013

• Board of BIOP graduate school, 2003 – 2005

• NBI educational committee, 2003 – 2010

• Board of high-technological network for biophotonics, 2005 – 2006

• Committee of Future Education in Natural Sciences, 2002 – 2003

Danish television

• 2015 March 4th on TV2

• http://www.dr.dk/nyheder/viden/her-er-aarets-eliteforskere

• TV appearance 2014

Newspapers

• Berlingske tidende February 2015

• The Danish scientific magazine 'Videnskab.dk'

• http://videnskab.dk/teknologi/kan-laserlys-og-nanopartikler-erstatte-kemoterapi

• LBO is expert on in vivo manipulation of living matter from the single molecule to whole cell level, on optical manipulation of individual metallic nanoparticles, on matter-light-nanoparticle interactions, and on in vitro investigations of nucleic acids. Methodologically, areas of expertise include optical manipulation, force spectroscopy, fluorescent visualization (also super-resolution), and single particle tracking.

Other activities and achievements/family

• Lene B. Oddershede was born in 1970.

  She is married to Ulrich J. Quaade and they have 3 sons born 1997, 2000 and 2006.

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