Short CV/Education and training

Current Position

  • Since 2014
    Co-Head for the Department of Medical Biosciences, Umeå University

  • Since 2014
    Director for the Biobank at Västerbottens County

  • Since 2014
    Senior Consultant in Pathology, NUS University Hospital, Umeå 2011-present

  • Since 2015
    Co-Director Wallenberg Center for Molecular Medicine, Umeå

  • Since 2010
    Professor in Pathology, Umeå University

  • Since 2008
    Adjuncted Group leader at Ludwig Institute for Cancer Research (LICR), Uppsala Branch

Previous Positions

  • 2008 – 2010
    Senior Investigator Award (50%), supported by the Swedish Cancer Society, Rudbeck Laboratory, Dep. of Genetics and Pathology, Uppsala University

  • 2007 – 2010
    Resident in Clinical Pathology (50%), University Hospital, Uppsala

  • 2002 – 2007
    Associate Member, Group Leader, Ludwig Institute for Cancer Research, Uppsala Branch, Sweden

  • 1998 – 2001
    Research Assistant, Medical Research Council, Ludwig Institute for Cancer Research, Uppsala Branch, Sweden

  • 1992 – 1993
    Lecturer, Department of Pathology, Umeå University, Sweden

  • 1989
    Lecturer, Department of Physiology, Umeå University

  • 1980 – 1982
    Nurse, Department of Urology, Umeå University hospital

  • Education

  • 1992
    Ph. D. Thesis: Endocrine Treatment of Prostatic Adenocarcinoma. An experimental study in the rat. Umeå University Medical Dissertations, New Series No.346, University of Umeå. ISSN 0346-6612 ISBN 91-7174-682-X. 1992. Main supervisor: Jan-Erik Damber

  • 1987
    Medical Doctor Umeå University

  • 1980
    Nurse, Umeå University

Selected publications

  • Hamidi A, Song J, Thakur T, Itoh S, Marcusson A, Bergh A, Heldin C-H, Landström M. TGFβ promotes prostate cancer cell migration via TRAF6-mediated ubiquitination of p85α causing activation of the PI3K-AKT pathway. Sci Signal. Jul 4;10(486). pii: eaal4186. doi: 10.1126/scisignal.aal4186.

  • Gudey SK, Sundar R, Heldin C-H, Bergh A, Landström M. Pro-invasive properties of Snail1 are regulated by sumoylation in response to TGFβ stimulation in prostate cancer. Oncotarget published on line August 9, 2017.

  • Song J, Mu Y, Li C, Bergh A, Miaczynska M, Heldin CH, Landström M. APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain. Oncotarget Nov 18. 2015. doi: 10.18632/oncotarget.6346

  • Sundar R, Gudey SK, Heldin C-H, Landström M. TRAF6 promotes TGF-induced invasion and cell cycle regulation via Lys63-linked polyubiquitination of K178 in TGF Type I receptor. Cell Cycle 2015;14(4):554-65.

    Gudey SK, Sundar R, Mu Y, Wallenius A, Zang G, Bergh A, Heldin CH, Landström M TRAF6 Stimulates the Tumor-Promoting Effects of TGFβ Type I Receptor Through Polyubiquitination and Activation of Presenilin 1. Sci Signal. 2014 Jan 7;7(307):ra2. doi: 10.1126/scisignal.2004207

  • Mu Y, Sundar R, Thakur N, Ekman M, Kumar S, Yakymovych M, Dimitrou L, Hermansson A, Bengoechea-Alonso MT, Ericsson J, Heldin C-H, Landström M. TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer. Nature Communications 2, 2011, 330 DOI: i.10.1038/ncomms1332.

  • Sorrentino A, Thakur N, Grimsby S, Marcusson A, Bulow v V, Zhang S, Schuster N, Heldin CH, Landström M. The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. Nature Cell Biology 2008 Oct;10(10):1199-207.

  • Edlund S*, Bu S*, Schuster N, Aspenström P, Heldin N-E, ten Dijke P, Heldin C-H, Landström M. TGF-1-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TAK1 and MKK3. Molecular Biology of the Cell 14:529-544, 2003. *joints first authors

  • Brodin G, ten Dijke P, Funa K, Heldin C-H, Landström M. Increased Smad Expression and Activation is Associated with Apoptosis in Normal and Malignant Prostate after Castration. Cancer Research 59:2731-2738, 1999.

  • Landström, M., Damber, J.-E., Bergh, A. Prostatic tumor regrowth after initially successful castration therapy may be related to a decreased apoptotic cell death rate. Cancer Research 54:4281-4284, 1994.

Complete list of publications

Membership in scientific bodies/juries

  • Commissions of trust

  • Associated Editor in Current Cancer Drug Targets Bentham Science Publishers Editorial Board, since 2012

  • Chairmen for Evaluation panel (PKA2) for the Swedish Cancer Society, since 2016

  • Steering board member Proteomics SciLife, since 2014

  • Reviewer for Science, Oncogene, Nature Comms, Nature Cell Biology, Oncotarget, Molecular Cell Biology, Molecular Biology of the Cell, Science Signaling, Cancer Letters, Cell Tissue and Research, Cancer Research. Referee for funding from Nordic Cancer Union (NCU) and Germani-Israeli Foundation for Scientific Research and Development (GIF)


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