Short CV/Education and training

Doctoral Degree

  • 2000-11-03 PhD in Obstetrics and Gynecology (Medical Science) at The Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg (GU), Sweden (2000-11-03)

Post Doctorial Position

  • 2002 – 2003
    Basic Medical Research Center, International University of Health and Welfare, Otawara, Japan, financed by The Swedish Foundation for International Cooperation in Research and Higher Education (STINT)

Docent level (Associate Professor)

  • Since 2004
    Associate professor (docent) 2004, GU and from 2015 at Karolinska Institutet (KI), Stockholm

Present Positions

  • Since 2017
    Professor: Reproductive Physiology, Department of Physiology and Pharmacology, KI, Stockholm

  • Since 2018
    Professor: Nanshan distinguish Professorship of outstanding talents (guest professorship), Department of Gynecology at the First Affiliated Hospital of Guangzhou Medical University, China

Previous Positions and Periods of Appointment

  • 2015 – 2017
    Senior Lecturer, Department of Physiology and Pharmacology, KI

  • 2009 – 2015
    Researcher, Institute of Neuroscience and Physiology, Department of Physiology, GU

  • 2009 – 2016
    Professor: “Longjiang Scholar” at Heilongjiang University, Department of Obstetrics and Gynecology, Harbin, China. This was a guest professorship

  • 2005 – 2008
    Junior researcher position at Swedish Research Council (VR) Institute of Neuroscience and Physiology, GU

  • 2000 – 2004
    Staff scientist at Department of Obstetrics and Gynecology, Wallenberg Laboratory, and lecturer at Department of Physiotherapy, GU

  • 1995 – 2000
    PhD student. Department of Obstetrics and Gynecology, GU

Selected publications

  • Wu X-K*, Stener-Victorin E*, Kuang H-Y, Ma H-L, Gao J-S, Xie L-Z, Hou L-H, Hu Z-X, Shao X-G, Ge J, Zhang J-F, Xue H-Y, Xu X-F, Liang R-N, Ma H-X, Yang H-W, Li W-L, Huang D-M, Sun Y, Hao C-F, Du S-M, Yang Z-W, Wang X, Yan Y, Chen X-H, Fu P, Ding C-F, Gao Y-Q, Zhou Z-M, Wang CC, Wu T-X, Liu J-P, Ng EHY, Legro RS, Zhang H for PCOSAct Study. Acupuncture and Clomiphene for Infertility in the Polycystic Ovary Syndrome: A Randomized Clinical Trial. JAMA 2017 Jun 27;317(24):2502-2514. doi: 10.1001/jama.2017.7217. PMID: 28655015 * Shared First Authors

  • Benrick A, Chanclón B, Micallef P, Wu Y, Hadi L, Shelton JM, Stener-Victorin E *, Wernstedt Asterholm I *. Adiponectin protects against development of metabolic disturbances in a PCOS mouse model. Proc Natl Acad Sci U S A. 2017; 114(34):E7187-E7196. pii: 201708854. doi: 10.1073/pnas.1708854114. * Shared Senior Authors

  • Benrick A, Kokosar M, Hu M, Larsson M, Maliqueo M, Marcondes RR, Soligo M, Protto V, Jerlhag E, Sazonova A, Behre CJ, Højlund K, Thoren P, Stener-Victorin E. Autonomic nervous system activation mediates the increase in whole-body glucose uptake in response to electroacupuncture. FASEB J. 2017; 31(8):3288-3297 pii: fj.201601381R. doi: 10.1096/fj.201601381R. [Epub ahead of print] PMID: 28404742

  • Kokosar M, Benrick A, Perfilyev A, Nilsson E, Fornes R, Maliqueo M, Behre CJ, Sazonova A, Ohlsson C, Ling C, Stener-Victorin E. Epigenetic and transcriptional alterations in human adipose tissue of polycystic ovary syndrome. Scientific Report. 2016; 6:22883. DOI: 10.1038/srep22883. PMID. 26975253

  • Hu M, Richard JE, Maliqueo M, Kokosar M, Fornes R, Benrick A, Jansson T, Ohlsson C, Wu X, Skibicka KP, Stener-Victorin E. Maternal testosterone exposure increases anxiety-like behavior and impacts the limbic system in the offspring. Proc Natl Acad Sci USA. 2015; 112(46):14348-53. PMID: 26578781.

  • Dumesic DA, Oberfield SE, Stener-Victorin E, Marshall JC, Laven JS, Legro RS. Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome. Endocr Rev. 2015 Oct;36(5):487-525. doi: 10.1210/er.2015-1018. PMID: 26426951

  • Urbanek M, Ehrmann D, Armstrong L, Young Lee J, Sisk R, Karaderi T, Barber T, McCarthy M, Franks S, Lindgren CM, Welt C, Diamanti-Kandarakis E, Panidis D, Goodarzi M, Azziz R, Zhang Y, James R, Olivier M, Kissebah A, Stener-Victorin E, Legro R, Dunaif A. Genomewide Association of Polycystic Ovary Syndrome Implicates Alterations in Gonadotropin Secretion in European Ancestry Populations. Nat Commun. 2015; 6:7502. PMID: 26284813.

  • Jedel E, Gustafson D, Waern M, Sverrisdottir YB, Landen M, Janson PO, et al. Sex steroids, insulin sensitivity and sympathetic nerve activity in relation to affective symptoms in women with polycystic ovary syndrome. Psychoneuroendocrinology. 2011 Nov;36(10):1470-9.

  • Jedel E, Labrie F, Oden A, Holm G, Nilsson L, Janson PO, et al. Impact of electro-acupuncture and physical exercise on hyperandrogenism and oligo/amenorrhea in women with polycystic ovary syndrome: a randomized controlled trial. Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E37-45.

  • Jedel E, Waern M, Gustafson D, Landen M, Eriksson E, Holm G, et al. Anxiety and depression symptoms in women with polycystic ovary syndrome compared with controls matched for body mass index. Hum Reprod. 2010 Feb;25(2):450-6.

  • Johansson J, Manneras-Holm L, Shao R, Olsson A, Lonn M, Billig H, et al. Electrical vs manual acupuncture stimulation in a rat model of polycystic ovary syndrome: different effects on muscle and fat tissue insulin signaling. PLoS One. 2013;8(1):e54357.

  • Johansson J, Redman L, Veldhuis PP, Sazonova A, Labrie F, Holm G, et al. Acupuncture for ovulation induction in polycystic ovary syndrome: a randomized controlled trial. Am J Physiol Endocrinol Metab. 2013 May 1;304(9):E934-43.

  • Johansson J, Yi F, Shao R, Lonn M, Billig H, Stener-Victorin E. Intense Acupuncture Normalizes Insulin Sensitivity, Increases Muscle GLUT4 Content, and Improves Lipid Profile in a Rat Model of Polycystic Ovary Syndrome. Am J Physiol Endocrinol Metab. 2010 Jul 27;299:E551-E9.

  • Maliqueo M, Sun M, Johansson J, Benrick A, Labrie F, Svensson H, et al. Continuous administration of a P450 aromatase inhibitor induces polycystic ovary syndrome with a metabolic and endocrine phenotype in female rats at adult age. Endocrinology. 2013 Jan;154(1):434-45.

  • Manneras-Holm L, Baghaei F, Holm G, Janson PO, Ohlsson C, Lonn M, et al. Coagulation and fibrinolytic disturbances in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2011 Apr;96(4):1068-76.

Complete list of publications

Selected projects

  • Developmental origin of androgen excess, insulin resistance and behavioral dysfunction in females

    The etiology of PCOS is not well understood but emerging evidence suggests that PCOS originates, at least in part, in fetal life and elevated maternal androgens and/or maternal obesity have been implicated to play a role, however the mechanisms are largely unknown. Maternal sex steroids and metabolic hormones regulate placental steroidogenesis and the transport of nutrients, functions that are critical for fetal growth and development. Maternal androgen excess and obesity might alter metabolism, sex steroid levels and nutrition delivery to the fetus via the placenta. In this project we propose that changes in placental function are involved in the intrauterine programming of PCOS.

    The overall hypothesis is that high maternal androgens and maternal obesity up-regulate placental steroid receptors and steroidogenic enzymes, which in turn alter metabolic pathways and contribute to the development of PCOS and related symptoms in the offspring.

  • Genome-wide DNA methylation and gene expression profiles in adipose and skeletal muscle tissue from women with and without PCOS

    The possibility of an epigenetic component of PCOS has only recently been explored. Interestingly, epigenetic modification of PGC-1α has been reported in granulosa cells from women with PCOS and a genome-wide methylation array of adipose tissue from prenatally androgenized female rhesus monkeys showed changes in methylation of genes in the TGF-β superfamily. These observations suggest that epigenetic modifications could be involved in diseases such as PCOS.

    This project aims to investigate differences in genome-wide gene expression and DNA methylation pattern in subcutaneous adipose tissue and skeletal muscle from women with and without PCOS. To investigate the importance of differential expression in adipose tissue, selected genes are biologically validated in a second case-control cohort matched for age, weight and BMI.

  • To elucidate the effect and mechanisms of acupuncture and exercise on insulin resistance and key signaling pathways in adipose and skeletal muscle tissue in translational studies

    Because women with PCOS require long-term treatment and current treatments often have severe metabolic and gastrointestinal side effects, there is a need for novel treatment options. Physical exercise and acupuncture with low-frequency electrical stimulation, both induces ovulation and decreases circulating androgens. In this project, we hypothesize that acupuncture treatment with muscle contractions, by reducing hyperandrogenemia and reversing insulin resistance, can modify key molecular alterations and epigenetic changes to the genomic DNA in adipose tissue and skeletal muscle to the same extent as exercise.

    Further, as the effect of acupuncture with low-frequency electrical stimulation are hypothesized to be mediated via sympathetic nervous system and/or dopaminergic system, we will administer blockers of α-adrenoceptor, β-adrenoceptor or dopamine1(D1)receptor, to elucidate which key signaling pathways mediate the effect in ovaries, adipose tissue and skeletal muscle.

Membership in scientific bodies/juries

  • Endocrine Society

  • European Society of Endocrinology

  • European Society of Human Reproduction and Embryology

  • European Association for the Study of Diabetes

  • Scandinavian Society for the Study of Diabetes

Grant Reviewer:

  • Swedish Research Council, Panel B1: Endocrinology and Metabolism

  • Medical Research council (MRC), 5 years MRC grants, UK. Wellbeing of Women Research Grant 2011, UK

  • Health Research Council of New Zealand (HRC), 3 years HRC grants, New Zealand

Editorial Board:

  • Associate Editor: Human Reproduction, since 2013

  • Associate Editor: Acupuncture in Medicine, BMJ group, since 2010

Soft Skills/Other activities and achievements

Other activities and achievements/family

  • Family situation:

    Married, Hans Victorin, two children, Maja born 1991 and Jacob born 1994

  • Activities: Kitesurfing, skiing and sailing


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