Dr. Malin Ah-King
Biological and related sciences, Evolutionary biology, Animal behaviour, Gender studies, Science studies
Prof. Manuela Schmidt PhD
Nominated by
- German Research Foundation (DFG)
- AcademiaNet member since 10.12.2012
- AcademiaNet- Selection Criteria
Employed by
- University of Vienna
Academic Discipline/Fields
- Natural sciences, mathematics and statistics
Field
Biological and related sciences, Health
Area of specialisation
Neurosciencesperipheral nervous systemsystems biology painchronic painion channelsmass spectrometry-based proteomicsforward and reverse translation mouse-human
Research interests
Research in our laboratory is driven by our motivation to decipher the dynamics of protein networks underlying vertebrate somatosensation in health, development (aging) and disease (chronic pain). Methodologically, we combine molecular biology, biochemistry and latest proteomics techniques, electrophysiology, pharmacology, mouse models of painful pathologies and in vivo virus-mediated gene transfer.
This multidisciplinary approach has enabled us to reveal ion channel-associated signaling complexes (i.e. the interactome of TRPV1, TRPA1 and Piezo2 channels) with pathological relevance for pain. Moreover, in a quantitative systems biology approach, we investigate spatiotemporal proteome dynamics both in mice and humans. Our research lives from our fruitful collaborations with basic researchers and clinicians alike facilitating forward and reverse translation of our research results.
In this way we strive to gain mechanistic insights into developmental and pain-associated plasticity – an endeavor, which lies at the heart of both understanding the molecular signature of chronic pain and identifying novel drug targets.
Distinctions and Awards
2018 Travel grant, eLife (early-career research travel grant programme)
2015/2019 Research awards (Foerderpreis) for two publications of my laboratory, German Pain Society
2015 Max von Frey-Prize 2015; awarded for innovative research on neuropathic pain; German Pain Society
Emmy Noether- Program, Independent Junior Research Group Leader, since April 2012
Dorris Neuroscience postdoctoral fellowship at TSRI, 2010 – 2011
DAAD (German Academic Exchange Service) postdoctoral fellowship, 2007 – 2009
Travel Allowance, Boehringer Ingelheim Fonds, 2003
Book-Grant, Oskar-Karl-Forster-Foundation, 2001
Stipendium für Hochbegabte (stipend for exceptional students), Bavarian Ministry for Cultural Affairs, 1997 – 2002
Award for Best University Entrance Diploma in Biology, German Association of Biologists (Vdbiol), 1997
Ruperti-Medal for Best University Entrance Diploma, Ruperti-Gymnasium, 1997
Interested in
- Membership in scientific bodies
Languages
English, German, Spanish
Doctorate
- 2006: Characterization of synaptic protein complexes in Drosophila melanogaster
Short CV/Education and training
- 1997 – 2002Diploma, Biology, University of Wuerzburg, Germany
- 2001 – 2002Master, Neurosciences, International Max Planck Research School Neurosciences, Goettingen, Germany
- 2002 – 2006PhD, Neurosciences, International Max Planck Research School Neurosciences, Laboratory of Stephan Sigrist, ENI-G, Goettingen, Germany
- 2007 – 2012Postdoc with Ardem Patapoutian, The Scripps Research Institute, La Jolla, California, USA
- 2012 – 2018Independent Research Group Leader, Emmy Noether-Program, DFG; MPI of Experimental Medicine (MPIEM), Goettingen, Germany
- 2019 – 2020W2-Professor, Faculty of Biology and Psychology, University of Goettingen, Germany
- Since 2020Full Professor (head of the Department of Pharmacology and Toxicology); University of Vienna, Austria
Selected publications
1. Julia R. Sondermann, Allison M. Barry, Olaf Jahn, Niklas Michel, Reham Abdelaziz, Sebastian Kügler, David Gomez-Varela, Manuela Schmidt (2019). Vti1b promotes TRPV1 sensitization during inflammatory pain. PAIN. doi: 10.1097/j.pain.0000000000001418 Awarded with “1st prize for pain research 2019” (Förderpreis für Schmerzforschung), German Pain Society; IF: 5.5
2. Allison M. Barry, Julia R. Sondermann, Jan-Henrik Sondermann, David Gomez-Varela and Manuela Schmidt (2018). Region resolved quantitative proteome profiling reveals molecular dynamics associated with chronic pain in the PNS and spinal cord. Front. Mol. Neurosci.; 10.3389/fnmol.2018.00259 IF: 3.9
3. Pratibha Narayanan, Meike Huette, Galina Kudryasheva, Francisco J Taberner, Stefan Lechner, Florian Rehfeldt, David Gomez-Varela, Manuela Schmidt (2018). Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons. eLife. doi: 10.7554/eLife.32346 IF: 7.7
4. Narayanan P, Sondermann J, Rouwette T, Karaca S, Urlaub H, Mitkovski M, Gomez-Varela D, Schmidt M. (2016). Native Piezo2 Interactomics Identifies Pericentrin as a Novel Regulator of Piezo2 in Somatosensory Neurons. J Proteome Res, 5;15(8):2676-87. doi: 10.1021/acs.jproteome.6b00235 IF: 4.2
5. Rouwette T, Sondermann J, Avenali L, Gomez-Varela D, Schmidt M. (2016). Standardized profiling of the membrane-enriched proteome of mouse dorsal root ganglia provides novel insights into chronic pain. Molecular & Cellular Proteomics, doi: 10.1074/mcp.M116.058966. IF: 5.9
6. Avenali L, Narayanan P, Rouwette T, Cervellini I, Sereda M, Gomez-Varela D, Schmidt M. (2014). Annexin A2 Regulates TRPA1-Dependent Nociception. J Neurosci. 34(44):14506-16. doi: 10.1523/JNEUROSCI.1801-14. Awarded with “1st prize for pain research 2015” (Förderpreis für Schmerzforschung), German Pain Society; IF: 5.9
7. Bruderer R, Bernhardt OM, Gandhi T, Xuan Y, Sondermann J, Schmidt M, Gomez-Varela D, Reiter L (2017).Optimization of Experimental Parameters in Data-Independent Mass Spectrometry Significantly Increases Depth and Reproducibility of Results. Mol Cell Proteomics. doi: 10.1074/mcp.RA117.000314 IF: 5.9
8. Bruderer R, Sondermann J, Tsou CC, Barrantes-Freer A, Stadelmann C, Nesvizhskii AI, Schmidt M, Reiter L, Gomez-Varela D. (2017). New targeted approaches for the quantification of data-independent acquisition mass spectrometry. Proteomics. doi: 10.1002/pmic.201700021 IF: 4.1
9. Coste B, Mathur J, Schmidt M, Earley TJ, Ranade S, Petrus MJ, Dubin AE, Patapoutian A. (2010) Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels Science, 330: 55-60; IF: 34.7
10. Schmidt M, Dubin AE, Petrus MJ, Earley TJ, Patapoutian A (2009). Nociceptive signals induce trafficking of TRPA1 to the plasma membrane. Neuron 64(4):498-509. IF: 13.9
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