Prof. Dr. Myriam Aouadi
HealthObesity, Diabetes, Immunology
Health
Gene and cell therapy
Cardiac disease, cardiac physiology, imaging, drug development, gene therapy, stem cell biology, regenerative medicine, cell therapy
Fellow of the British Pharmacological Society, 2013
Fellow of the Society of Biology, 2010
Fellow of the ISHR, 2010
Fellow of the European Society of Cardiology, 2008
Fellow of the American Heart Association, 2001
Presidents Distinguished Lecture Award ISHR, 2011
English
Halliday J, Harding SE. Removal of sialic acid from cardiac sarcolemma does not affect contractile function in electrically stimulated guinea-pig atria. Nature (Lond.). 1980;286:819-21.
Harding SE, Jones SM, O'Gara P, del Monte F, Vescovo G, Poole-Wilson PA. Isolated ventricular myocytes from failing and non-failing human heart; the relation of age and clinical status of patients to isoproterenol response. J.Mol.Cell.Cardiol. 1992;24:549-64.
Brady AJ, Warren JB, Poole-Wilson PA, Williams TJ, Harding SE. Nitric oxide attenuates cardiac myocyte contraction. Am.J.Physiol. 1993;265:H176-H182
del Monte F, Kaumann AJ, Poole-Wilson PA, Wynne DG, Harding SE. Coexistence of functioning beta 1- and beta 2-adrenoceptors in single myocytes from human ventricle. Circulation. 1993;88:854-63.
Davies CH, Davia K, Bennett JG, Pepper JR, Poole-Wilson PA, Harding SE. Reduced contraction and altered frequency response of isolated ventricular myocytes from patients with heart failure. Circulation. 1995;92:2540-9.
Gong H, Sun H, Koch W J, Rau T, Eschenhagen T, Ravens U, Heubach J F, Adamson D L and Harding S E. The specific beta2AR blocker, ICI 118,551, actively decreases contraction through a Gi-coupled form of the beta2AR in myocytes from failing human heart. Circulation. 2002;105:2497-2503.
Brito-Martins M, Harding SE, Ali NN (2008). Beta 1- and beta 2AR responses in cardiomyocytes derived from human embryonic stem cells: comparison with failing and non-failing adult human heart. Brit. J. Pharmacol: 153: 751-759.
Nikolaev VO, Moshkov A, Lyon AR, Miragoli M, Novak P, Paur H, Lohse MJ, Korchev YE, Harding SE, Gorelik J. beta 2-Adrenergic Receptor Redistribution in Heart Failure Changes cAMP Compartmentation. Science. 2010;327:1653-1657
Lyon AR, Bannister ML, Collins T, Pearce E, Sepehripour AH, Dubb SS, Garcia E, O'Gara P, Liang L, Kohlbrenner E, Hajjar RJ, Peters NS, Poole-Wilson PA, Macleod KT, Harding SE. SERCA2a Gene Transfer Decreases SR Calcium Leak and Reduces Ventricular Arrhythmias in a Model of Chronic Heart Failure. Circ Arrhythm Electrophysiol. 2011 Jun;4(3):362-72
Paur H, Wright PT, Sikkel MB, Tranter MH, Mansfield C, O'Gara P, Stuckey DJ, Nikolaev VO, Diakonov I, Pannell L, Gong H, Sun H, Peters NS, Petrou M, Zheng Z, Gorelik J, Lyon AR, Harding SE. High Levels of Circulating Epinephrine Trigger Apical Cardiodepression in a beta2-Adrenoceptor/Gi-Dependent Manner: A New Model of Takotsubo Cardiomyopathy. Circulation 2012 126(6), 697-706.
Wellcome Trust Clinical PhD Studentship. Hydrogel support of delivery of Induced Pluripotent Stem Cell derived-cardiomyocytes to infarcted heart. With Prof Molly Stevens. 2010 – 2013
NC3Rs. Stem cell-derived cardiomyocytes for detection of cardiotoxicity in cancer therapeutics, 2010 – 2012
BHF New Horizons Grant: cAMP/cGMP localisation in cardiovascular tissue by a new nanoscale multifunctional scanning technique. 2010 – 2012 (PI Julia Gorelik)
Leducq network of Excellence – Translating human pluripotent stem cells from heart disease models to cardiac repair
Marie Curie Fellowship: Thyroid hormone breakdown in the maintenance of immaturity in human pluripotent stem cell-derived cardiomyocytes. 2011 – 2013
BHF Programme Grant. Human pluripotent stem cells to study beta-adrenoceptor mechanisms. With Chris Denning, Steve Hill Nottingham. 2012 – 2017
BHF New Horizons Program Grant (PI) cAMP/cGMP localisation in cardiac myocytes by a new nanoscale multifunctional scanning technique. 2013 – 2018 (PI Julia Gorelik)
Director, BHF Cardiovascular Regenerative Medicine Centre, Imperial College
Past-President, European Section of the International Society for Heart Research, 2008 – 2010
Co-ordinating Investigator, Clinical Trial of Gene Therapy in Heart Failure
Editorial Board, Cardiovascular Research
Nuffield Council for Bioethics, since 2007
Nuffield Council Working Party on Organ Donation, Volunteering and Payment, 2010 – 2011
Scientific Advisory Board: Stem Cells for Safer Medicines (PPP), since 2008
MRC Regenerative Medicine Research Committee, since 2011
BHF Chairs and Programme Grants Committee 2011
MRC Populations, Systems and Medicine Board, since 2009
European Society of Cardiology Programme Committee, since 2008
European Database of Women Experts in Science, Engineering and Technology (WITEC)
MRC Advisory Board, 2001 – 2004
MRC Expert Panel for Career Awards, 2002 – 2004
British Heart Foundation Awards Committee, 2004 – 2008
BBRSC Studentships Awards Committee
http://www.thenakedscientists.com/HTML/interviews/interview/1197/
http://www.bbc.co.uk/news/health-22336300
http://www.futuremedicine.com/doi/abs/10.2217/fca.13.64
http://www.independent.co.uk/news/science/gene-therapy-to-offer-up-to-1m-heart-patients-new-lease-of-life-8595621.html
Mentoring, outreach
Husband Ray and daughter Elizabeth
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HealthObesity, Diabetes, Immunology
Biological and related sciences , HealthInternal medicine, Hematology - hemostasis, Clinical laboratory sciences - hematology
Biological and related sciences , HealthCell Biology, Cellular signaling, Cancer biology, Cancer therapy
HealthAcademic Medicine