Prof. Sian Harding

• 1977
  B.Sc. Hons 1st Class, Pharmacology and Biochemistry, King's College, London
  
  

• Halliday J, Harding SE. Removal of sialic acid from cardiac sarcolemma does not affect contractile function in electrically stimulated guinea-pig atria. Nature (Lond.). 1980;286:819-21.

• Harding SE, Jones SM, O'Gara P, del Monte F, Vescovo G, Poole-Wilson PA. Isolated ventricular myocytes from failing and non-failing human heart; the relation of age and clinical status of patients to isoproterenol response. J.Mol.Cell.Cardiol. 1992;24:549-64.

• Brady AJ, Warren JB, Poole-Wilson PA, Williams TJ, Harding SE. Nitric oxide attenuates cardiac myocyte contraction. Am.J.Physiol. 1993;265:H176-H182

• del Monte F, Kaumann AJ, Poole-Wilson PA, Wynne DG, Harding SE. Coexistence of functioning beta 1- and beta 2-adrenoceptors in single myocytes from human ventricle. Circulation. 1993;88:854-63.

• Davies CH, Davia K, Bennett JG, Pepper JR, Poole-Wilson PA, Harding SE. Reduced contraction and altered frequency response of isolated ventricular myocytes from patients with heart failure. Circulation. 1995;92:2540-9.

• Gong H, Sun H, Koch W J, Rau T, Eschenhagen T, Ravens U, Heubach J F, Adamson D L and Harding S E. The specific beta2AR blocker, ICI 118,551, actively decreases contraction through a Gi-coupled form of the beta2AR in myocytes from failing human heart. Circulation. 2002;105:2497-2503.

• Brito-Martins M, Harding SE, Ali NN (2008). Beta 1- and beta 2AR responses in cardiomyocytes derived from human embryonic stem cells: comparison with failing and non-failing adult human heart. Brit. J. Pharmacol: 153: 751-759.

• Nikolaev VO, Moshkov A, Lyon AR, Miragoli M, Novak P, Paur H, Lohse MJ, Korchev YE, Harding SE, Gorelik J. beta 2-Adrenergic Receptor Redistribution in Heart Failure Changes cAMP Compartmentation. Science. 2010;327:1653-1657

• Lyon AR, Bannister ML, Collins T, Pearce E, Sepehripour AH, Dubb SS, Garcia E, O'Gara P, Liang L, Kohlbrenner E, Hajjar RJ, Peters NS, Poole-Wilson PA, Macleod KT, Harding SE. SERCA2a Gene Transfer Decreases SR Calcium Leak and Reduces Ventricular Arrhythmias in a Model of Chronic Heart Failure. Circ Arrhythm Electrophysiol. 2011 Jun;4(3):362-72

• Paur H, Wright PT, Sikkel MB, Tranter MH, Mansfield C, O'Gara P, Stuckey DJ, Nikolaev VO, Diakonov I, Pannell L, Gong H, Sun H, Peters NS, Petrou M, Zheng Z, Gorelik J, Lyon AR, Harding SE. High Levels of Circulating Epinephrine Trigger Apical Cardiodepression in a beta2-Adrenoceptor/Gi-Dependent Manner: A New Model of Takotsubo Cardiomyopathy. Circulation 2012 126(6), 697-706.

• Wellcome Trust Clinical PhD Studentship. Hydrogel support of delivery of Induced Pluripotent Stem Cell derived-cardiomyocytes to infarcted heart. With Prof Molly Stevens. 2010 – 2013

• NC3Rs. Stem cell-derived cardiomyocytes for detection of cardiotoxicity in cancer therapeutics, 2010 – 2012

• BHF New Horizons Grant: cAMP/cGMP localisation in cardiovascular tissue by a new nanoscale multifunctional scanning technique. 2010 – 2012 (PI Julia Gorelik)

• Leducq network of Excellence – Translating human pluripotent stem cells from heart disease models to cardiac repair

• Marie Curie Fellowship: Thyroid hormone breakdown in the maintenance of immaturity in human pluripotent stem cell-derived cardiomyocytes. 2011 – 2013

• BHF Programme Grant. Human pluripotent stem cells to study beta-adrenoceptor mechanisms. With Chris Denning, Steve Hill Nottingham. 2012 – 2017

• BHF New Horizons Program Grant (PI) cAMP/cGMP localisation in cardiac myocytes by a new nanoscale multifunctional scanning technique. 2013 – 2018 (PI Julia Gorelik)

• Director, BHF Cardiovascular Regenerative Medicine Centre, Imperial College

• Past-President, European Section of the International Society for Heart Research, 2008 – 2010

• Co-ordinating Investigator, Clinical Trial of Gene Therapy in Heart Failure

• Editorial Board, Cardiovascular Research

• Nuffield Council for Bioethics, since 2007

• Nuffield Council Working Party on Organ Donation, Volunteering and Payment, 2010 – 2011

• Scientific Advisory Board: Stem Cells for Safer Medicines (PPP), since 2008

• MRC Regenerative Medicine Research Committee, since 2011

• BHF Chairs and Programme Grants Committee 2011

• MRC Populations, Systems and Medicine Board, since 2009

• European Society of Cardiology Programme Committee, since 2008

• European Database of Women Experts in Science, Engineering and Technology (WITEC)

• MRC Advisory Board, 2001 – 2004

• MRC Expert Panel for Career Awards, 2002 – 2004

• British Heart Foundation Awards Committee, 2004 – 2008

• BBRSC Studentships Awards Committee

• http://www.thenakedscientists.com/HTML/interviews/interview/1197/

• http://www.bbc.co.uk/news/health-22336300

• http://www.futuremedicine.com/doi/abs/10.2217/fca.13.64

• http://www.independent.co.uk/news/science/gene-therapy-to-offer-up-to-1m-heart-patients-new-lease-of-life-8595621.html

Soft Skills

• Mentoring, outreach

Other activities and achievements/family

• Husband Ray and daughter Elizabeth

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